7QEY
| human Connexin 26 class 1 hexamer at 90mmHg PCO2, pH7.4 | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | 著者 | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | 登録日 | 2021-12-03 | 公開日 | 2022-03-30 | 最終更新日 | 2022-11-09 | 実験手法 | ELECTRON MICROSCOPY (2 Å) | 主引用文献 | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
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7QET
| human Connexin 26 dodecamer at 20mmHg PCO2, pH7.4 | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | 著者 | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | 登録日 | 2021-12-03 | 公開日 | 2022-03-30 | 最終更新日 | 2022-05-18 | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | 主引用文献 | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
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8PSR
| ERK2 covalently bound to SynthRevD-12-opt artificial peptide | 分子名称: | GLYCEROL, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Sok, P, Poti, A, Gogl, G, Remenyi, A. | 登録日 | 2023-07-13 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold To Be Published
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8PNA
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5KID
| Tightening the Recognition of Tetravalent Zr and Th Complexes by the Siderophore-Binding Mammalian Protein Siderocalin for Theranostic Applications | 分子名称: | CHLORIDE ION, GLYCEROL, N,N'-(butane-1,4-diyl)bis(N-{3-[(2,3-dihydroxybenzene-1-carbonyl)amino]propyl}-2,3-dihydroxybenzamide), ... | 著者 | Rupert, P.B, Strong, R.K. | 登録日 | 2016-06-16 | 公開日 | 2017-04-26 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Engineered Recognition of Tetravalent Zirconium and Thorium by Chelator-Protein Systems: Toward Flexible Radiotherapy and Imaging Platforms. Inorg Chem, 55, 2016
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5K7S
| MicroED structure of proteinase K at 1.6 A resolution | 分子名称: | CALCIUM ION, Proteinase K | 著者 | de la Cruz, M.J, Hattne, J, Shi, D, Seidler, P, Rodriguez, J, Reyes, F.E, Sawaya, M.R, Cascio, D, Eisenberg, D, Gonen, T. | 登録日 | 2016-05-26 | 公開日 | 2017-04-05 | 最終更新日 | 2018-08-22 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.6 Å) | 主引用文献 | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED. Nat. Methods, 14, 2017
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8PT0
| ERK2 covelently bound to RU75 cyclohexenone based inhibitor | 分子名称: | GLYCEROL, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Sok, P, Poti, A, Remenyi, A, Gogl, G. | 登録日 | 2023-07-13 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold To Be Published
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5K8Y
| Structure of the Mus musclus Langerin carbohydrate recognition domain | 分子名称: | C-type lectin domain family 4 member K, CALCIUM ION, GLYCEROL, ... | 著者 | Loll, B, Aretz, J, Rademacher, C, Wahl, M.C. | 登録日 | 2016-05-31 | 公開日 | 2016-12-07 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent. J. Biol. Chem., 292, 2017
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8D6E
| Crystal Structure of Human Myt1 Kinase domain Bounded with RP-6306 | 分子名称: | (1P)-2-amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide, 1,2-ETHANEDIOL, GLYCEROL, ... | 著者 | Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F. | 登録日 | 2022-06-06 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J.Med.Chem., 65, 2022
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8D6D
| Crystal Structure of Human Myt1 Kinase domain Bounded with compound 39 | 分子名称: | (1P)-2-amino-5-bromo-1-(3-hydroxy-2,6-dimethylphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, 1,2-ETHANEDIOL, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, ... | 著者 | Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F. | 登録日 | 2022-06-06 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J.Med.Chem., 65, 2022
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8PMC
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8PNC
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8D6F
| Crystal Structure of Human Myt1 Kinase domain Bounded with Eph receptor inhibitor / compound 41 | 分子名称: | (1M)-2-amino-1-(5-hydroxy-2-methylphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, SULFATE ION | 著者 | Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F. | 登録日 | 2022-06-06 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J.Med.Chem., 65, 2022
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8PIW
| Crystal structure of Hen Egg White Lysozyme co-crystallized with 10 mM TbXo4-NMet2 | 分子名称: | 6-[[4-[(6-carboxypyridin-2-yl)methyl]-7-[3-(dimethylamino)propyl]-1,4,7-triazonan-1-yl]methyl]pyridine-2-carboxylic acid, CHLORIDE ION, Lysozyme C, ... | 著者 | Alsalman, Z, Girard, E. | 登録日 | 2023-06-22 | 公開日 | 2024-07-10 | 最終更新日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Influence of Chemical Modifications of the Crystallophore on Protein Nucleating Properties and Supramolecular Interactions Network. Chemistry, 30, 2024
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8PMV
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8D6C
| Crystal Structure of Human Myt1 Kinase domain Bounded with compound 28 | 分子名称: | (1P)-2-amino-6-bromo-1-(3-hydroxy-2,6-dimethylphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, 1,2-ETHANEDIOL, GLYCEROL, ... | 著者 | Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F. | 登録日 | 2022-06-06 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J.Med.Chem., 65, 2022
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5G6V
| Crystal structure of the PCTAIRE1 kinase in complex with inhibitor | 分子名称: | 1,2-ETHANEDIOL, 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, CYCLIN-DEPENDENT KINASE 16 | 著者 | Dixon-Clarke, S.E, Galan Bartual, S, Elkins, J, Savitsky, P, Kopec, J, Mackenzie, A, Tallant, C, Heroven, C, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A. | 登録日 | 2016-08-16 | 公開日 | 2016-11-23 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16. Biochem.J., 474, 2017
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5KGI
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5KHP
| Tightening the Recognition of Tetravalent Zr and Th Complexes by the Siderophore-Binding Mammalian Protein Siderocalin for Theranostic Applications | 分子名称: | GLYCEROL, N,N'-(butane-1,4-diyl)bis(N-{3-[(2,3-dihydroxybenzene-1-carbonyl)amino]propyl}-2,3-dihydroxybenzamide), Neutrophil gelatinase-associated lipocalin, ... | 著者 | Rupert, P.B, Strong, R.K. | 登録日 | 2016-06-15 | 公開日 | 2017-04-26 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Engineered Recognition of Tetravalent Zirconium and Thorium by Chelator-Protein Systems: Toward Flexible Radiotherapy and Imaging Platforms. Inorg Chem, 55, 2016
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5G30
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7QWK
| GCN2 (EIF2ALPHA KINASE 4, E2AK4) IN COMPLEX WITH COMPOUND 2 | 分子名称: | (2~{S})-~{N}-[(1~{S})-1-[4-[(6-pyridin-4-ylquinazolin-2-yl)amino]phenyl]ethyl]piperidine-2-carboxamide, DIMETHYL SULFOXIDE, eIF-2-alpha kinase GCN2 | 著者 | Maia de Oliveira, T. | 登録日 | 2022-01-25 | 公開日 | 2022-05-04 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The structure of human GCN2 reveals a parallel, back-to-back kinase dimer with a plastic DFG activation loop motif. Biochem.J., 477, 2020
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5KEA
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8DEA
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5G1X
| Crystal structure of Aurora-A kinase in complex with N-Myc | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, AURORA KINASE A, MAGNESIUM ION, ... | 著者 | Richards, M.W, Burgess, S.G, Bayliss, R. | 登録日 | 2016-03-31 | 公開日 | 2016-11-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Structural Basis of N-Myc Binding by Aurora-A and its Destabilization by Kinase Inhibitors Proc.Natl.Acad.Sci.USA, 113, 2016
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5G2Z
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