Tightening the Recognition of Tetravalent Zr and Th Complexes by the Siderophore-Binding Mammalian Protein Siderocalin for Theranostic Applications

Summary for 5KHP

DescriptorNeutrophil gelatinase-associated lipocalin, ZIRCONIUM ION, N,N'-(butane-1,4-diyl)bis(N-{3-[(2,3-dihydroxybenzene-1-carbonyl)amino]propyl}-2,3-dihydroxybenzamide), ... (6 entities in total)
Functional Keywordssiderophore-binding, ngal, metal binding protein
Biological sourceHomo sapiens (Human)
Cellular locationSecreted  P80188
Total number of polymer chains3
Total molecular weight65476.24
Rupert, P.B.,Strong, R.K. (deposition date: 2016-06-15, release date: 2017-04-26, Last modification date: 2017-09-27)
Primary citation
Captain, I.,Deblonde, G.J.,Rupert, P.B.,An, D.D.,Illy, M.C.,Rostan, E.,Ralston, C.Y.,Strong, R.K.,Abergel, R.J.
Engineered Recognition of Tetravalent Zirconium and Thorium by Chelator-Protein Systems: Toward Flexible Radiotherapy and Imaging Platforms.
Inorg Chem, 55:11930-11936, 2016
PubMed: 27802058 (PDB entries with the same primary citation)
DOI: 10.1021/acs.inorgchem.6b02041
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22610012.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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