9AY7
| Crystal structure of CRAF/MEK1 complex with NST-628 and inactive RAF | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-07 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
|
|
9AYA
| Crystal structure of CRAF/MEK complex with NST-628 and active RAF dimer | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-07 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
|
|
9AXY
| Crystal structure of BRAF/MEK complex with NST-628 and inactive RAF | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
|
|
5HOT
| Structural Basis for Inhibitor-Induced Aggregation of HIV-1 Integrase | 分子名称: | (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, Integrase | 著者 | Gupta, K, Turkki, V, Sherrill-Mix, S, Hwang, Y, Eilers, G, Taylor, L, McDanal, C, Wang, P, Temelkoff, D, Nolte, R, Velthuisen, E, Jeffrey, J, Van Duyne, G.D, Bushman, F.D. | 登録日 | 2016-01-19 | 公開日 | 2016-12-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016
|
|
5HRP
| HIV Integrase Catalytic Domain containing F185K + A124T mutations complexed with GSK0002 | 分子名称: | (2S)-tert-butoxy[1-(3,4-difluorobenzyl)-6-methyl-4-(5-methyl-3,4-dihydro-2H-chromen-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]acetic acid, 1,2-ETHANEDIOL, CACODYLATE ION, ... | 著者 | Nolte, R.T. | 登録日 | 2016-01-24 | 公開日 | 2016-12-14 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016
|
|
9BFN
| Cryo-EM co-structure of AcrB with the CU232 efflux pump inhibitor | 分子名称: | (2R)-1-(4-aminopiperidin-1-yl)-3-[3-(trifluoromethyl)phenoxy]propan-2-ol, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Multidrug efflux pump subunit AcrB | 著者 | Su, C.C. | 登録日 | 2024-04-18 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment. mBio, 14, 2023
|
|
5HRS
| HIV Integrase Catalytic Domain containing F185K + A124N + T125A mutations complexed with GSK0002 | 分子名称: | (2S)-tert-butoxy[1-(3,4-difluorobenzyl)-6-methyl-4-(5-methyl-3,4-dihydro-2H-chromen-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]acetic acid, 1,2-ETHANEDIOL, CACODYLATE ION, ... | 著者 | Nolte, R.T. | 登録日 | 2016-01-24 | 公開日 | 2016-12-14 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016
|
|
9BFM
| Cryo-EM co-structure of AcrB with the EPM35 efflux pump inhibitor | 分子名称: | (2S)-1-(3,4-dichlorophenoxy)-3-(4-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}piperidin-1-yl)propan-2-ol, Multidrug efflux pump subunit AcrB | 著者 | Su, C.C. | 登録日 | 2024-04-18 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment. mBio, 14, 2023
|
|
9BFH
| Cryo-EM co-structure of AcrB with the CU032 efflux pump inhibitor | 分子名称: | (2S)-1-[(3R)-3-aminopyrrolidin-1-yl]-3-(3,4-dichlorophenoxy)propan-2-ol, Multidrug efflux pump subunit AcrB | 著者 | Su, C.C. | 登録日 | 2024-04-17 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | 主引用文献 | Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment. mBio, 14, 2023
|
|
9BFT
| Cryo-EM co-structure of AcrB with CU244 | 分子名称: | (2S)-1-{[(1R,5R)-3-azabicyclo[3.1.0]hexan-6-yl]amino}-3-(3,5-dichlorophenoxy)propan-2-ol, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Multidrug efflux pump subunit AcrB | 著者 | Su, C.C. | 登録日 | 2024-04-18 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | 主引用文献 | Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment. mBio, 14, 2023
|
|
5K4P
| Catalytic Domain of MCR-1 phosphoethanolamine transferase | 分子名称: | Probable phosphatidylethanolamine transferase Mcr-1, ZINC ION, sorbitol | 著者 | Stojanoski, V, Palzkill, T, Prasad, B.V.V, Sankaran, B. | 登録日 | 2016-05-21 | 公開日 | 2016-08-31 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.318 Å) | 主引用文献 | Structure of the catalytic domain of the colistin resistance enzyme MCR-1. Bmc Biol., 14, 2016
|
|
5K7O
| MicroED structure of lysozyme at 1.8 A resolution | 分子名称: | CHLORIDE ION, Lysozyme C, SODIUM ION | 著者 | de la Cruz, M.J, Hattne, J, Shi, D, Seidler, P, Rodriguez, J, Reyes, F.E, Sawaya, M.R, Cascio, D, Eisenberg, D, Gonen, T. | 登録日 | 2016-05-26 | 公開日 | 2017-04-05 | 最終更新日 | 2018-08-22 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.8 Å) | 主引用文献 | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED. Nat. Methods, 14, 2017
|
|
5FHH
| Structure of human Pif1 helicase domain residues 200-641 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase PIF1, TETRAFLUOROALUMINATE ION | 著者 | Zhou, X, Ren, W, Bharath, S.R, Song, H. | 登録日 | 2015-12-22 | 公開日 | 2016-03-30 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1 Cell Rep, 14, 2016
|
|
3EXY
| |
5L1M
| |
5KUC
| Crystal structure of trypsin activated Cry6Aa | 分子名称: | Pesticidal crystal protein Cry6Aa | 著者 | Kelker, M.S, Xu, X, Lee, M, Chan, M, Hung, S, Dementiev, K, Hey, T, Chikwana, V.M, Narva, K.E. | 登録日 | 2016-07-13 | 公開日 | 2016-08-03 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins. Bmc Biol., 14, 2016
|
|
5KM2
| |
5KM8
| |
3FTT
| Crystal Structure of the galactoside O-acetyltransferase from Staphylococcus aureus | 分子名称: | Putative acetyltransferase SACOL2570 | 著者 | Knapik, A.A, Shumilin, I.A, Cui, H, Xu, X, Chruszcz, M, Zimmerman, M.D, Cymborowski, M, Anderson, W.F, Savchenko, A, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2009-01-13 | 公開日 | 2009-03-03 | 最終更新日 | 2022-04-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus. J.Struct.Funct.Genom., 14, 2013
|
|
5HR4
| Structure of Type IIL restriction-modification enzyme MmeI in complex with DNA has implications for engineering of new specificities | 分子名称: | CALCIUM ION, DNA (5'-D(P*GP*TP*TP*AP*TP*GP*TP*CP*GP*GP*AP*TP*A)-3'), DNA (5'-D(P*TP*AP*TP*CP*CP*GP*AP*CP*AP*TP*AP*AP*C)-3'), ... | 著者 | Callahan, S.J, Luyten, Y.A, Gupta, Y.K, Wilson, G.G, Roberts, R.J, Morgan, R.D, Aggarwal, A.K. | 登録日 | 2016-01-22 | 公開日 | 2016-04-27 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.5964 Å) | 主引用文献 | Structure of Type IIL Restriction-Modification Enzyme MmeI in Complex with DNA Has Implications for Engineering New Specificities. Plos Biol., 14, 2016
|
|
5HRN
| HIV Integrase Catalytic Domain containing F185K mutation complexed with GSK0002 | 分子名称: | (2S)-tert-butoxy[1-(3,4-difluorobenzyl)-6-methyl-4-(5-methyl-3,4-dihydro-2H-chromen-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]acetic acid, 1,2-ETHANEDIOL, CACODYLATE ION, ... | 著者 | Nolte, R.T. | 登録日 | 2016-01-23 | 公開日 | 2016-12-14 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016
|
|
4YZW
| Crystal structure of AgPPO8 | 分子名称: | AGAP004976-PA, COPPER (II) ION | 著者 | Hu, Y. | 登録日 | 2015-03-25 | 公開日 | 2015-12-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The structure of a prophenoloxidase (PPO) from Anopheles gambiae provides new insights into the mechanism of PPO activation. Bmc Biol., 14, 2016
|
|
5K7R
| MicroED structure of trypsin at 1.7 A resolution | 分子名称: | CALCIUM ION, Cationic trypsin | 著者 | de la Cruz, M.J, Hattne, J, Shi, D, Seidler, P, Rodriguez, J, Reyes, F.E, Sawaya, M.R, Cascio, D, Eisenberg, D, Gonen, T. | 登録日 | 2016-05-26 | 公開日 | 2017-04-05 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.7 Å) | 主引用文献 | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED. Nat. Methods, 14, 2017
|
|
3CUQ
| |
5HVH
| Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Carboxypeptidase B2, ... | 著者 | Zhou, X, Weeks, S.D, Strelkov, S.V, Declerck, P.J. | 登録日 | 2016-01-28 | 公開日 | 2016-06-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity. J.Thromb.Haemost., 14, 2016
|
|