4YZW

Crystal structure of AgPPO8

Summary for 4YZW

• Entry DOI: 10.2210/pdb4yzw/pdb
• Descriptor: AGAP004976-PA, COPPER (II) ION (3 entities in total)
• Functional Keywords: prophenoloxidase, ppo, type 3 copper enzyme, oxidoreductase
• Biological source: Anopheles gambiae (African malaria mosquito)
• Total number of polymer chains: 2
• Total formula weight: 163901.04

Authors

Hu, Y. (deposition date: 2015-03-25, release date: 2015-12-23, Last modification date: 2024-10-23)

Primary citation

Hu, Y.,Wang, Y.,Deng, J.,Jiang, H.
The structure of a prophenoloxidase (PPO) from Anopheles gambiae provides new insights into the mechanism of PPO activation.
Bmc Biol., 14:2-2, 2016

PubMed Abstract: Phenoloxidase (PO)-catalyzed melanization is a universal defense mechanism of insects against pathogenic and parasitic infections. In mosquitos such as Anopheles gambiae, melanotic encapsulation is a resistance mechanism against certain parasites that cause malaria and filariasis. PO is initially synthesized by hemocytes and released into hemolymph as inactive prophenoloxidase (PPO), which is activated by a serine protease cascade upon recognition of foreign invaders. The mechanisms of PPO activation and PO catalysis have been elusive.

PubMed: 26732497
DOI: 10.1186/s12915-015-0225-2

Experimental method

X-RAY DIFFRACTION (2.6 Å)