PDB: 224004 件ウェブページステータス検索Chemie searchBIRD

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6YBJ	Structure of MBP-Mcl-1 in complex with compound 3e 分子名称: (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[(2-methylpyrazol-3-yl)methoxy]phenyl]propanoic acid, CHLORIDE ION, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, ... 著者 Dokurno, P, Surgenor, A.E, Murray, J.B. 登録日 2020-03-17 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor. J.Med.Chem., 63, 2020
1SEN	Endoplasmic reticulum protein Rp19 O95881 分子名称: CHLORIDE ION, PLATINUM (II) ION, Thioredoxin-like protein p19 著者 Liu, Z.-J, Chen, L, Tempel, W, Shah, A, Lee, D, Dailey, T.A, Mayer, M.R, Rose, J.P, Richardson, D.C, Richardson, J.S, Dailey, H.A, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) 登録日 2004-02-17 公開日 2004-07-13 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (1.199 Å) 主引用文献 Endoplasmic reticulum protein Rp19 To be Published
6OYG	Crystal structure of H62F mutant of human macrophage migration inhibitory factor 分子名称: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... 著者 Pantouris, G, Lolis, E. 登録日 2019-05-14 公開日 2020-04-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel. Cell Chem Biol, 27, 2020
6YPN	Crystal Structure of CK2alpha with 2 molecules of ADP bound 分子名称: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, Casein kinase II subunit alpha, ... 著者 Brear, P, Hyvonen, M. 登録日 2020-04-16 公開日 2020-07-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Proposed Allosteric Inhibitors Bind to the ATP Site of CK2 alpha. J.Med.Chem., 63, 2020
6GYP	Cryo-EM structure of the CBF3-core-Ndc10-DBD complex of the budding yeast kinetochore 分子名称: ARGININE, ASPARAGINE, Centromere DNA-binding protein complex CBF3 subunit A, ... 著者 Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. 登録日 2018-07-01 公開日 2018-12-05 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
7NSU	ColicinE9 intact translocation complex 分子名称: Colicin-E9, Outer membrane protein F, Tol-Pal system protein TolB, ... 著者 Webby, M.N, Kleanthous, C, Lukoyanova, N, Housden, N.G. 登録日 2021-03-08 公開日 2021-08-11 最終更新日 2021-11-17 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Porin threading drives receptor disengagement and establishes active colicin transport through Escherichia coli OmpF. Embo J., 40, 2021
7NST	ColicinE9 partial translocation complex 分子名称: Colicin-E9, Outer membrane protein F, Tol-Pal system protein TolB 著者 Webby, M.N, Kleanthous, C, Lukoyanova, N, Housden, N.G. 登録日 2021-03-08 公開日 2021-08-11 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Porin threading drives receptor disengagement and establishes active colicin transport through Escherichia coli OmpF. Embo J., 40, 2021
6UP2	Crystal structure of the murine DHX36 helicase 分子名称: CHLORIDE ION, Dhx36 protein, GLYCEROL 著者 Chuenchor, W, Jiang, J, Xiao, T.S. 登録日 2019-10-16 公開日 2020-10-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Crystal structure of the murine DHX36 helicase To be published
6YBG	Structure of Mcl-1 in complex with compound 2g 分子名称: (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(3-chlorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-(2-methoxyphenyl)propanoic acid, CHLORIDE ION, Induced myeloid leukemia cell differentiation protein Mcl-1 著者 Dokurno, P, Surgenor, A.E, Murray, J.B. 登録日 2020-03-17 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor. J.Med.Chem., 63, 2020
6P4B	HyHEL10 fab variant HyHEL10-4x (heavy chain mutations L4F, Y33H, S56N, and Y58F) bound to hen egg lysozyme variant HEL2x-flex (mutations R21Q, R73E, C76S, and C94S) 分子名称: CHLORIDE ION, HyHEL10 Fab heavy chain, HyHEL10 Fab light chain, ... 著者 Langley, D.B, Christ, D. 登録日 2019-05-27 公開日 2020-05-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens. Proc.Natl.Acad.Sci.USA, 117, 2020
7SOH	Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox 分子名称: Chlorotoxin 著者 Gewe, M.M, Strong, R.K. 登録日 2021-10-30 公開日 2022-06-29 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol, 25, 2018
7OI8	Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 3A 分子名称: 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... 著者 Cheng, J, Berninghausen, O, Beckmann, R. 登録日 2021-05-11 公開日 2021-09-15 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 A distinct assembly pathway of the human 39S late pre-mitoribosome. Nat Commun, 12, 2021
7OID	Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 5A 分子名称: 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... 著者 Cheng, J, Berninghausen, O, Beckmann, R. 登録日 2021-05-11 公開日 2021-09-15 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 A distinct assembly pathway of the human 39S late pre-mitoribosome. Nat Commun, 12, 2021
7TEA	Crystal structure of S. aureus GlnR-DNA complex 分子名称: CALCIUM ION, DNA (5'-D(*CP*GP*TP*GP*TP*CP*AP*GP*AP*TP*AP*AP*TP*CP*TP*GP*AP*CP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*GP*TP*CP*AP*GP*AP*TP*TP*AP*TP*CP*TP*GP*AP*CP*AP*CP*G)-3'), ... 著者 Schumacher, M.A. 登録日 2022-01-04 公開日 2022-06-29 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria. Nat Commun, 13, 2022
7TEC	Structure of the Listeria monocytogenes GlnR-DNA complex to 3.45 Angstrom 分子名称: DNA (5'-D(*CP*GP*TP*GP*TP*CP*AP*GP*AP*TP*AP*AP*TP*CP*TP*GP*AP*CP*AP*CP*G)-3'), HTH-type transcriptional regulator GlnR 著者 Schumacher, M.A, Brennan, R.G. 登録日 2022-01-04 公開日 2022-06-29 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria. Nat Commun, 13, 2022
7O3C	Murine supercomplex CIII2CIV in the mature unlocked conformation 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... 著者 Vercellino, I, Sazanov, L.A. 登録日 2021-04-01 公開日 2021-10-13 最終更新日 2021-10-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structure and assembly of the mammalian mitochondrial supercomplex CIII 2 CIV. Nature, 598, 2021
7O3E	Murine supercomplex CIII2CIV in the intermediate locked conformation 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... 著者 Vercellino, I, Sazanov, L.A. 登録日 2021-04-01 公開日 2021-10-13 最終更新日 2021-10-27 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure and assembly of the mammalian mitochondrial supercomplex CIII 2 CIV. Nature, 598, 2021
7O3H	Murine CIII2 focus-refined from supercomplex CICIII2 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... 著者 Vercellino, I, Sazanov, L.A. 登録日 2021-04-01 公開日 2021-10-13 最終更新日 2021-10-27 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Structure and assembly of the mammalian mitochondrial supercomplex CIII 2 CIV. Nature, 598, 2021
6PAE	Dickeya chrysanthemi complex with L-Asp at pH 5.6 分子名称: 1,2-ETHANEDIOL, ASPARTIC ACID, GLYCEROL, ... 著者 Lubkowski, J, Wlodawer, A. 登録日 2019-06-11 公開日 2019-09-04 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Geometric considerations support the double-displacement catalytic mechanism of l-asparaginase. Protein Sci., 28, 2019
6P1B	Transcription antitermination factor Q21 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Q protein 著者 Yin, Z, Ebright, R.H. 登録日 2019-05-19 公開日 2019-06-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.942 Å) 主引用文献 Structural basis of Q-dependent antitermination. Proc.Natl.Acad.Sci.USA, 116, 2019
6YCG	Structure the bromelain protease from Ananas comosus in complex with the TLCK inhibitor 分子名称: CITRIC ACID, FBSB, ISOPROPYL ALCOHOL, ... 著者 Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. 登録日 2020-03-18 公開日 2020-11-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity. Sci Rep, 10, 2020
6URC	Crystal structure of IRE1a in complex with compound 18 分子名称: 2-chloro-N-(6-methyl-5-{[3-(2-{[(3S)-piperidin-3-yl]amino}pyrimidin-4-yl)pyridin-2-yl]oxy}naphthalen-1-yl)benzene-1-sulfonamide, GLYCEROL, Serine/threonine-protein kinase/endoribonuclease IRE1 著者 Wallweber, H.H, Wang, W. 登録日 2019-10-23 公開日 2019-11-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Disruption of IRE1 alpha through its kinase domain attenuates multiple myeloma. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6YPG	Crystal Structure of CK2alpha with Compound 2 bound to second crystal form 分子名称: 4-[(4-naphthalen-2-yl-1,3-thiazol-2-yl)amino]-2-oxidanyl-benzoic acid, ACETATE ION, Casein kinase II subunit alpha 著者 Brear, P, Hyvonen, M. 登録日 2020-04-16 公開日 2020-07-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Proposed Allosteric Inhibitors Bind to the ATP Site of CK2 alpha. J.Med.Chem., 63, 2020
6J99	Cryo-EM structure of human DOT1L in complex with an H2B-monoubiquitinated nucleosome 分子名称: DNA (144-MER), DNA (145-MER), Histone H2A, ... 著者 Yao, T, Huang, J. 登録日 2019-01-22 公開日 2019-02-27 最終更新日 2019-04-10 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome. Cell Res., 29, 2019
6PAC	E. coli L-asparaginase II in complex with L-Asp at pH 5.6 分子名称: ASPARTIC ACID, IMIDAZOLE, L-asparaginase 2 著者 Lubkowski, J, Wlodawer, A. 登録日 2019-06-11 公開日 2019-09-04 最終更新日 2019-10-02 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Geometric considerations support the double-displacement catalytic mechanism of l-asparaginase. Protein Sci., 28, 2019

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