6YBJ
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![BU of 6ybj by Molmil](/molmil-images/mine/6ybj) | Structure of MBP-Mcl-1 in complex with compound 3e | 分子名称: | (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[(2-methylpyrazol-3-yl)methoxy]phenyl]propanoic acid, CHLORIDE ION, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, ... | 著者 | Dokurno, P, Surgenor, A.E, Murray, J.B. | 登録日 | 2020-03-17 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor. J.Med.Chem., 63, 2020
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1SEN
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![BU of 1sen by Molmil](/molmil-images/mine/1sen) | Endoplasmic reticulum protein Rp19 O95881 | 分子名称: | CHLORIDE ION, PLATINUM (II) ION, Thioredoxin-like protein p19 | 著者 | Liu, Z.-J, Chen, L, Tempel, W, Shah, A, Lee, D, Dailey, T.A, Mayer, M.R, Rose, J.P, Richardson, D.C, Richardson, J.S, Dailey, H.A, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2004-02-17 | 公開日 | 2004-07-13 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (1.199 Å) | 主引用文献 | Endoplasmic reticulum protein Rp19 To be Published
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6OYG
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6YPN
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6GYP
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![BU of 6gyp by Molmil](/molmil-images/mine/6gyp) | Cryo-EM structure of the CBF3-core-Ndc10-DBD complex of the budding yeast kinetochore | 分子名称: | ARGININE, ASPARAGINE, Centromere DNA-binding protein complex CBF3 subunit A, ... | 著者 | Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. | 登録日 | 2018-07-01 | 公開日 | 2018-12-05 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
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7NSU
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![BU of 7nsu by Molmil](/molmil-images/mine/7nsu) | ColicinE9 intact translocation complex | 分子名称: | Colicin-E9, Outer membrane protein F, Tol-Pal system protein TolB, ... | 著者 | Webby, M.N, Kleanthous, C, Lukoyanova, N, Housden, N.G. | 登録日 | 2021-03-08 | 公開日 | 2021-08-11 | 最終更新日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Porin threading drives receptor disengagement and establishes active colicin transport through Escherichia coli OmpF. Embo J., 40, 2021
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7NST
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![BU of 7nst by Molmil](/molmil-images/mine/7nst) | ColicinE9 partial translocation complex | 分子名称: | Colicin-E9, Outer membrane protein F, Tol-Pal system protein TolB | 著者 | Webby, M.N, Kleanthous, C, Lukoyanova, N, Housden, N.G. | 登録日 | 2021-03-08 | 公開日 | 2021-08-11 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Porin threading drives receptor disengagement and establishes active colicin transport through Escherichia coli OmpF. Embo J., 40, 2021
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6UP2
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6YBG
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![BU of 6ybg by Molmil](/molmil-images/mine/6ybg) | Structure of Mcl-1 in complex with compound 2g | 分子名称: | (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(3-chlorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-(2-methoxyphenyl)propanoic acid, CHLORIDE ION, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Dokurno, P, Surgenor, A.E, Murray, J.B. | 登録日 | 2020-03-17 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor. J.Med.Chem., 63, 2020
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6P4B
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![BU of 6p4b by Molmil](/molmil-images/mine/6p4b) | HyHEL10 fab variant HyHEL10-4x (heavy chain mutations L4F, Y33H, S56N, and Y58F) bound to hen egg lysozyme variant HEL2x-flex (mutations R21Q, R73E, C76S, and C94S) | 分子名称: | CHLORIDE ION, HyHEL10 Fab heavy chain, HyHEL10 Fab light chain, ... | 著者 | Langley, D.B, Christ, D. | 登録日 | 2019-05-27 | 公開日 | 2020-05-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens. Proc.Natl.Acad.Sci.USA, 117, 2020
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7SOH
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7OI8
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![BU of 7oi8 by Molmil](/molmil-images/mine/7oi8) | Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 3A | 分子名称: | 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... | 著者 | Cheng, J, Berninghausen, O, Beckmann, R. | 登録日 | 2021-05-11 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | A distinct assembly pathway of the human 39S late pre-mitoribosome. Nat Commun, 12, 2021
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7OID
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![BU of 7oid by Molmil](/molmil-images/mine/7oid) | Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 5A | 分子名称: | 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... | 著者 | Cheng, J, Berninghausen, O, Beckmann, R. | 登録日 | 2021-05-11 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | A distinct assembly pathway of the human 39S late pre-mitoribosome. Nat Commun, 12, 2021
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7TEA
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![BU of 7tea by Molmil](/molmil-images/mine/7tea) | Crystal structure of S. aureus GlnR-DNA complex | 分子名称: | CALCIUM ION, DNA (5'-D(*CP*GP*TP*GP*TP*CP*AP*GP*AP*TP*AP*AP*TP*CP*TP*GP*AP*CP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*GP*TP*CP*AP*GP*AP*TP*TP*AP*TP*CP*TP*GP*AP*CP*AP*CP*G)-3'), ... | 著者 | Schumacher, M.A. | 登録日 | 2022-01-04 | 公開日 | 2022-06-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria. Nat Commun, 13, 2022
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7TEC
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7O3C
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![BU of 7o3c by Molmil](/molmil-images/mine/7o3c) | Murine supercomplex CIII2CIV in the mature unlocked conformation | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | 著者 | Vercellino, I, Sazanov, L.A. | 登録日 | 2021-04-01 | 公開日 | 2021-10-13 | 最終更新日 | 2021-10-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure and assembly of the mammalian mitochondrial supercomplex CIII 2 CIV. Nature, 598, 2021
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7O3E
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![BU of 7o3e by Molmil](/molmil-images/mine/7o3e) | Murine supercomplex CIII2CIV in the intermediate locked conformation | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | 著者 | Vercellino, I, Sazanov, L.A. | 登録日 | 2021-04-01 | 公開日 | 2021-10-13 | 最終更新日 | 2021-10-27 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure and assembly of the mammalian mitochondrial supercomplex CIII 2 CIV. Nature, 598, 2021
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7O3H
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![BU of 7o3h by Molmil](/molmil-images/mine/7o3h) | Murine CIII2 focus-refined from supercomplex CICIII2 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | 著者 | Vercellino, I, Sazanov, L.A. | 登録日 | 2021-04-01 | 公開日 | 2021-10-13 | 最終更新日 | 2021-10-27 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structure and assembly of the mammalian mitochondrial supercomplex CIII 2 CIV. Nature, 598, 2021
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6PAE
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6P1B
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6YCG
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![BU of 6ycg by Molmil](/molmil-images/mine/6ycg) | Structure the bromelain protease from Ananas comosus in complex with the TLCK inhibitor | 分子名称: | CITRIC ACID, FBSB, ISOPROPYL ALCOHOL, ... | 著者 | Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. | 登録日 | 2020-03-18 | 公開日 | 2020-11-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity. Sci Rep, 10, 2020
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6URC
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![BU of 6urc by Molmil](/molmil-images/mine/6urc) | Crystal structure of IRE1a in complex with compound 18 | 分子名称: | 2-chloro-N-(6-methyl-5-{[3-(2-{[(3S)-piperidin-3-yl]amino}pyrimidin-4-yl)pyridin-2-yl]oxy}naphthalen-1-yl)benzene-1-sulfonamide, GLYCEROL, Serine/threonine-protein kinase/endoribonuclease IRE1 | 著者 | Wallweber, H.H, Wang, W. | 登録日 | 2019-10-23 | 公開日 | 2019-11-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Disruption of IRE1 alpha through its kinase domain attenuates multiple myeloma. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6YPG
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6J99
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6PAC
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