6YCG

Structure the bromelain protease from Ananas comosus in complex with the TLCK inhibitor

Summary for 6YCG

• Entry DOI: 10.2210/pdb6ycg/pdb
• Related: 6Y6L
• Descriptor: FBSB, alpha-D-xylopyranose-(1-2)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: cysteine protease, stem bromelain protein, hydrolase
• Biological source: Ananas comosus (Pineapple)
• Total number of polymer chains: 2
• Total formula weight: 48877.32

Authors

Azarkan, M.,Charlier, P.,Herman, R.,Delbrassine, F.,Sauvage, E.,M Rabet, N.,Calvo Esposito, R.,Kerff, F. (deposition date: 2020-03-18, release date: 2020-11-25, Last modification date: 2024-01-24)

• Primary citation: Azarkan, M.,Maquoi, E.,Delbrassine, F.,Herman, R.,M'Rabet, N.,Calvo Esposito, R.,Charlier, P.,Kerff, F.; Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.; Sci Rep, 10:19570-19570, 2020; PubMed: 33177555; DOI: 10.1038/s41598-020-76172-5

Experimental method

X-RAY DIFFRACTION (1.45 Å)