PDB: 5515 件ウェブページステータス検索Chemie searchBIRD

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6AZW	IDO1/FXB-001116 crystal structure 分子名称: (2R)-N-(4-cyanophenyl)-2-[cis-4-(quinolin-4-yl)cyclohexyl]propanamide, Indoleamine 2,3-dioxygenase 1 著者 Lewis, H.A, Lammens, A, Steinbacher, S. 登録日 2017-09-13 公開日 2018-03-21 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6AQZ	Crystal structure of a gdp-l-fucose synthetase from Naegleria fowleri bound to NADP 分子名称: 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, gdp-l-fucose synthetase 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-08-21 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of a gdp-l-fucose synthetase from Naegleria fowleri bound to NADP To Be Published
6AQY	Crystal structure of a gdp-l-fucose synthetase from Naegleria fowleri 分子名称: CHLORIDE ION, SULFATE ION, gdp-l-fucose synthetase 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-08-21 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Crystal structure of a gdp-l-fucose synthetase from Naegleria fowleri To Be Published
6BVP	Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase N27A from Cupriavidus metallidurans 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION 著者 Yang, Y, Liu, F, Liu, A. 登録日 2017-12-13 公開日 2018-06-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.903 Å) 主引用文献 Adapting to oxygen: 3-Hydroxyanthrinilate 3,4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities. J. Biol. Chem., 293, 2018
6BVQ	Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase N27A from Cupriavidus metallidurans in complex with 4-Cl-3-HAA 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate 3,4-dioxygenase, 4-CHLORO-3-HYDROXYANTHRANILIC ACID, ... 著者 Yang, Y, Liu, F, Liu, A. 登録日 2017-12-13 公開日 2018-06-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.084 Å) 主引用文献 Adapting to oxygen: 3-Hydroxyanthrinilate 3,4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities. J. Biol. Chem., 293, 2018
6BS7	Crystal structure of Adenylosuccinate synthetase from Legionella pneumophila Philadelphia 1 分子名称: Adenylosuccinate synthetase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-12-01 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure of Adenylosuccinate synthetase from Legionella pneumophila to be published
6BVR	Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase I142A from Cupriavidus metallidurans 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION 著者 Yang, Y, Liu, F, Liu, A. 登録日 2017-12-13 公開日 2018-06-06 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Adapting to oxygen: 3-Hydroxyanthrinilate 3,4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities. J. Biol. Chem., 293, 2018
6C25	Crystal structure of Adenylosuccinate synthetase from Legionella pneumophila Philadelphia 1 in complex with GDP 分子名称: Adenylosuccinate synthetase, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2018-01-06 公開日 2018-03-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of Adenylosuccinate synthetase from Legionella pneumophila Philadelphia 1 in complex with GDP to be published
6BVS	Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase I142A from Cupriavidus metallidurans in complex with 4-Cl-3-HAA 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate 3,4-dioxygenase, 4-CHLORO-3-HYDROXYANTHRANILIC ACID, ... 著者 Yang, Y, Liu, F, Liu, A. 登録日 2017-12-13 公開日 2018-06-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.318 Å) 主引用文献 Adapting to oxygen: 3-Hydroxyanthrinilate 3,4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities. J. Biol. Chem., 293, 2018
7X3K	Cryo-EM structure of RAC in the State C2 RNC-RAC complex 分子名称: Ribosome-associated complex subunit SSZ1, Zuotin 著者 Chen, Y, Gao, N. 登録日 2022-03-01 公開日 2022-06-29 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (6 Å) 主引用文献 Structural remodeling of ribosome associated Hsp40-Hsp70 chaperones during co-translational folding. Nat Commun, 13, 2022
7OWG	human DEPTOR in a complex with mutant human mTORC1 A1459P 分子名称: DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ... 著者 Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L. 登録日 2021-06-18 公開日 2021-09-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Elife, 10, 2021
7WYF	Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with its inhibitor 50 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... 著者 Zhu, L, Li, H. 登録日 2022-02-16 公開日 2023-02-22 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with its inhibitor 50 To Be Published
5OWI	The dynamic dimer structure of the chaperone Trigger Factor (conformer 1) 分子名称: Trigger factor 著者 Morgado, L, Burmann, B.M, Sharpe, T, Mazur, A, Hiller, S. 登録日 2017-09-01 公開日 2017-11-29 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 The dynamic dimer structure of the chaperone Trigger Factor. Nat Commun, 8, 2017
5OWJ	The dynamic dimer structure of the chaperone Trigger Factor (conformer 2) 分子名称: Trigger factor 著者 Morgado, L, Burmann, B.M, Sharpe, T, Mazur, A, Hiller, S. 登録日 2017-09-01 公開日 2017-11-29 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 The dynamic dimer structure of the chaperone Trigger Factor. Nat Commun, 8, 2017
7P0N	Crystal structure of L-Trp/Indoleamine 2,3-dioxygenagse 1 (hIDO1) complex with the JK-loop refined in the open conformation 分子名称: CHLORIDE ION, GLYCEROL, Indoleamine 2,3-dioxygenase 1, ... 著者 Mirgaux, M, Wouters, J. 登録日 2021-06-30 公開日 2021-12-29 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Temporary Intermediates of L-Trp Along the Reaction Pathway of Human Indoleamine 2,3-Dioxygenase 1 and Identification of an Exo Site. Int J Tryptophan Res, 14, 2021
7P0R	Crystal structure of L-Trp/Indoleamine 2,3-dioxygenase (hIDO1) complex with the JK-loop refined in the intermediate conformation 分子名称: GLYCEROL, Indoleamine 2,3-dioxygenase 1, N'-Formylkynurenine, ... 著者 Mirgaux, M, Wouters, J. 登録日 2021-06-30 公開日 2021-12-29 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Temporary Intermediates of L-Trp Along the Reaction Pathway of Human Indoleamine 2,3-Dioxygenase 1 and Identification of an Exo Site. Int J Tryptophan Res, 14, 2021
5N7T	Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-(5,6-dichloro-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid 分子名称: 3-(5,6-DICHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC ACID, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Rowland, P. 登録日 2017-02-21 公開日 2017-06-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis. Bioorg. Med. Chem. Lett., 27, 2017
7PE9	cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement 分子名称: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEB	cryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomer 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEC	cryo-EM structure of DEPTOR bound to human mTOR complex 1, DEPt-bound subset local refinement 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.24 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PE8	cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer 分子名称: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEA	cryo-EM structure of DEPTOR bound to human mTOR complex 1, overall refinement 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.07 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PE7	cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement 分子名称: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-15 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (3.41 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
5NA5	Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) apo structure 分子名称: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Rowland, P. 登録日 2017-02-27 公開日 2017-06-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun, 8, 2017
5MZI	Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-(5-chloro-6-cyclopropoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid 分子名称: 3-(5-chloro-6-cyclopropoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Rowland, P. 登録日 2017-01-31 公開日 2017-04-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis. J. Med. Chem., 60, 2017

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