5N7T
Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-(5,6-dichloro-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid
Summary for 5N7T
Entry DOI | 10.2210/pdb5n7t/pdb |
Descriptor | Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | kmo, kynurenine 3-monooxygenase, oxidoreductase |
Biological source | Pseudomonas fluorescens |
Total number of polymer chains | 2 |
Total formula weight | 104409.94 |
Authors | Rowland, P. (deposition date: 2017-02-21, release date: 2017-06-14, Last modification date: 2024-05-08) |
Primary citation | Liddle, J.,Beaufils, B.,Binnie, M.,Bouillot, A.,Denis, A.A.,Hann, M.M.,Haslam, C.P.,Holmes, D.S.,Hutchinson, J.P.,Kranz, M.,McBride, A.,Mirguet, O.,Mole, D.J.,Mowat, C.G.,Pal, S.,Rowland, P.,Trottet, L.,Uings, I.J.,Walker, A.L.,Webster, S.P. The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis. Bioorg. Med. Chem. Lett., 27:2023-2028, 2017 Cited by PubMed: 28336141DOI: 10.1016/j.bmcl.2017.02.078 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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