5N7T
Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-(5,6-dichloro-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0004502 | molecular_function | kynurenine 3-monooxygenase activity |
| A | 0006569 | biological_process | L-tryptophan catabolic process |
| A | 0009435 | biological_process | NAD+ biosynthetic process |
| A | 0016174 | molecular_function | NAD(P)H oxidase H2O2-forming activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| A | 0019674 | biological_process | NAD+ metabolic process |
| A | 0019805 | biological_process | quinolinate biosynthetic process |
| A | 0043420 | biological_process | anthranilate metabolic process |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0070189 | biological_process | kynurenine metabolic process |
| A | 0071949 | molecular_function | FAD binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0004502 | molecular_function | kynurenine 3-monooxygenase activity |
| B | 0006569 | biological_process | L-tryptophan catabolic process |
| B | 0009435 | biological_process | NAD+ biosynthetic process |
| B | 0016174 | molecular_function | NAD(P)H oxidase H2O2-forming activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| B | 0019674 | biological_process | NAD+ metabolic process |
| B | 0019805 | biological_process | quinolinate biosynthetic process |
| B | 0043420 | biological_process | anthranilate metabolic process |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0070189 | biological_process | kynurenine metabolic process |
| B | 0071949 | molecular_function | FAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 37 |
| Details | binding site for residue FAD A 501 |
| Chain | Residue |
| A | ILE13 |
| A | ALA56 |
| A | ARG111 |
| A | GLY134 |
| A | LEU135 |
| A | ALA165 |
| A | ASP166 |
| A | GLY167 |
| A | ALA171 |
| A | GLY310 |
| A | ASP311 |
| A | GLY14 |
| A | GLY321 |
| A | GLN322 |
| A | GLY323 |
| A | MET324 |
| A | ASN325 |
| A | CL502 |
| A | JHY503 |
| A | GOL504 |
| A | GOL505 |
| A | HOH653 |
| A | GLY16 |
| A | HOH685 |
| A | HOH686 |
| A | HOH699 |
| A | HOH707 |
| A | HOH728 |
| A | HOH747 |
| A | HOH798 |
| A | HOH832 |
| A | LEU17 |
| A | ALA18 |
| A | GLU37 |
| A | ARG38 |
| A | ARG39 |
| A | LEU55 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 502 |
| Chain | Residue |
| A | PRO318 |
| A | GLN322 |
| A | GLY323 |
| A | FAD501 |
| A | HOH863 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue JHY A 503 |
| Chain | Residue |
| A | ALA56 |
| A | ARG84 |
| A | TYR98 |
| A | ILE106 |
| A | ILE224 |
| A | PHE238 |
| A | PRO318 |
| A | PHE319 |
| A | HIS320 |
| A | GLY321 |
| A | ASN369 |
| A | MET373 |
| A | TYR404 |
| A | FAD501 |
| A | GOL506 |
| A | HOH816 |
| A | HOH832 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | GLY16 |
| A | ARG51 |
| A | ARG111 |
| A | FAD501 |
| A | HOH730 |
| A | HOH745 |
| A | HOH843 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | LEU292 |
| A | ALA293 |
| A | PRO315 |
| A | MET316 |
| A | FAD501 |
| A | HOH608 |
| A | HOH803 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 506 |
| Chain | Residue |
| A | ARG84 |
| A | PRO97 |
| A | TYR98 |
| A | JHY503 |
| A | HOH658 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 507 |
| Chain | Residue |
| A | LEU25 |
| A | ARG28 |
| A | ASN29 |
| A | VAL332 |
| A | ALA335 |
| A | GLU336 |
| A | HOH656 |
| A | HOH678 |
| A | HOH724 |
| A | HOH842 |
| A | HOH915 |
| site_id | AC8 |
| Number of Residues | 38 |
| Details | binding site for residue FAD B 501 |
| Chain | Residue |
| B | ALA56 |
| B | ARG111 |
| B | GLY134 |
| B | LEU135 |
| B | ALA165 |
| B | ASP166 |
| B | GLY167 |
| B | ALA171 |
| B | GLY310 |
| B | ASP311 |
| B | GLY321 |
| B | GLN322 |
| B | GLY323 |
| B | MET324 |
| B | ASN325 |
| B | CL502 |
| B | JHY503 |
| B | GOL504 |
| B | GOL505 |
| B | HOH652 |
| B | HOH653 |
| B | HOH668 |
| B | HOH677 |
| B | HOH680 |
| B | HOH683 |
| B | HOH777 |
| B | HOH839 |
| B | HOH841 |
| B | ILE13 |
| B | GLY14 |
| B | GLY16 |
| B | LEU17 |
| B | ALA18 |
| B | GLU37 |
| B | ARG38 |
| B | ARG39 |
| B | ILE53 |
| B | LEU55 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 502 |
| Chain | Residue |
| B | PRO318 |
| B | GLN322 |
| B | GLY323 |
| B | FAD501 |
| B | HOH824 |
| site_id | AD1 |
| Number of Residues | 17 |
| Details | binding site for residue JHY B 503 |
| Chain | Residue |
| B | ALA56 |
| B | ARG84 |
| B | LEU213 |
| B | ILE215 |
| B | ILE224 |
| B | PHE238 |
| B | PRO318 |
| B | PHE319 |
| B | HIS320 |
| B | GLY321 |
| B | ASN369 |
| B | MET373 |
| B | TYR404 |
| B | FAD501 |
| B | HOH601 |
| B | HOH701 |
| B | HOH727 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 504 |
| Chain | Residue |
| B | LEU17 |
| B | ARG39 |
| B | ARG111 |
| B | ASN115 |
| B | FAD501 |
| B | HOH843 |
| B | HOH900 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 505 |
| Chain | Residue |
| B | LEU292 |
| B | ALA293 |
| B | PRO315 |
| B | MET316 |
| B | FAD501 |
| B | HOH618 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 506 |
| Chain | Residue |
| B | ARG84 |
| B | GLN96 |
| B | PRO97 |
| B | TYR98 |
| B | ARG386 |
| B | HOH696 |
| B | HOH705 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 507 |
| Chain | Residue |
| B | LEU25 |
| B | ARG28 |
| B | ASN29 |
| B | VAL332 |
| B | ALA335 |
| B | GLU336 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28336141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28398044","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28604669","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29429898","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5X6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5X6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y7A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y7A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
