5MZI

Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-(5-chloro-6-cyclopropoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

Summary for 5MZI

Entry DOI	10.2210/pdb5mzi/pdb
Descriptor	Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	kmo, oxidoreductase
Biological source	Pseudomonas fluorescens
Total number of polymer chains	2
Total formula weight	104793.69
Authors	Rowland, P. (deposition date: 2017-01-31, release date: 2017-04-19, Last modification date: 2017-05-10)
Primary citation	Walker, A.L.,Ancellin, N.,Beaufils, B.,Bergeal, M.,Binnie, M.,Bouillot, A.,Clapham, D.,Denis, A.,Haslam, C.P.,Holmes, D.S.,Hutchinson, J.P.,Liddle, J.,McBride, A.,Mirguet, O.,Mowat, C.G.,Rowland, P.,Tiberghien, N.,Trottet, L.,Uings, I.,Webster, S.P.,Zheng, X.,Mole, D.J. Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis. J. Med. Chem., 60:3383-3404, 2017 Cited by PubMed: 28398044 DOI: 10.1021/acs.jmedchem.7b00055 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation