PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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5ND7	Microtubule-bound MKLP2 motor domain in the presence of AMPPNP 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF20A, ... 著者 Atherton, J, Yu, I.-M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A. 登録日 2017-03-07 公開日 2017-10-04 実験手法 ELECTRON MICROSCOPY (7.9 Å) 主引用文献 The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry. Elife, 6, 2017
1Q4N	Structural studies of Phe256Trp of human salivary alpha-amylase: implications for the role of a conserved water molecule and its associated chain in enzyme activity 分子名称: Alpha-amylase, salivary, CALCIUM ION, ... 著者 Ramasubbu, N. 登録日 2003-08-04 公開日 2004-03-16 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Structural studies of a Phe256Trp mutant of human salivary alpha-amylase: implications for the role of a conserved water molecule in enzyme activity Arch.Biochem.Biophys., 421, 2004
4YBI	Crystal structure of BACE with amino thiazine inhibitor LY2811376 分子名称: (4S)-4-[2,4-difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine, Beta-secretase 1, GLYCEROL 著者 Timm, D.E. 登録日 2015-02-18 公開日 2015-04-01 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor. J.Neurosci., 31, 2011
4WHH	A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1 分子名称: C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR, SULFATE ION, Serine/threonine-protein kinase PLK1 著者 Bang, J.K. 登録日 2014-09-22 公開日 2014-12-03 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1. J.Med.Chem., 58, 2015
1N9E	Crystal structure of Pichia pastoris Lysyl Oxidase PPLO 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Guss, J.M, Duff, A.P. 登録日 2002-11-24 公開日 2004-01-13 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 The Crystal Structure of Pichia pastoris Lysyl Oxidase Biochemistry, 42, 2003
1NJI	Structure of chloramphenicol bound to the 50S ribosomal subunit 分子名称: 23S ribosomal RNA, 50S ribosomal protein L10e, 50S ribosomal protein L13P, ... 著者 Hansen, J.L, Moore, P.B, Steitz, T.A. 登録日 2002-12-31 公開日 2003-07-22 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of the Large Ribosomal Subunit J.Mol.Biol., 330, 2003
1N9P	Crystal Structure of the Cytoplasmic Domain of G-protein Activated Inward Rectifier Potassium Channel 1 分子名称: G protein-activated inward rectifier potassium channel 1 著者 Nishida, M, MacKinnon, R. 登録日 2002-11-26 公開日 2003-01-07 最終更新日 2017-08-02 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Basis of Inward Rectification: Cytoplasmic Pore of the G Protein-Gated Inward Rectifier GIRK1 at 1.8 A Resolution Cell(Cambridge,Mass.), 111, 2002
1OVE	The structure of p38 alpha in complex with a dihydroquinolinone 分子名称: 1-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE, GLYCEROL, Mitogen-activated protein kinase 14 著者 Fitzgerald, C.E, Patel, S.B, Becker, J.W, Cameron, P.M, Zaller, D, Pikounis, V.B, O'Keefe, S.J, Scapin, G. 登録日 2003-03-26 公開日 2003-09-02 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity Nat.Struct.Biol., 10, 2003
1OY7	Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) 分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, AEVVAVKSE peptide, Baculoviral IAP repeat-containing protein 7, ... 著者 Franklin, M.C, Kadkhodayan, S, Ackerly, H, Alexandru, D, Distefano, M.D, Elliott, L.O, Flygare, J.A, Vucic, D, Deshayes, K, Fairbrother, W.J. 登録日 2003-04-03 公開日 2003-08-26 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP) Biochemistry, 42, 2003
1OUK	The structure of p38 alpha in complex with a pyridinylimidazole inhibitor 分子名称: 4-[5-[2-(1-PHENYL-ETHYLAMINO)-PYRIMIDIN-4-YL]-1-METHYL-4-(3-TRIFLUOROMETHYLPHENYL)-1H-IMIDAZOL-2-YL]-PIPERIDINE, Mitogen-activated protein kinase 14, SULFATE ION 著者 Fitzgerald, C.E, Patel, S.B, Becker, J.W, Cameron, P.M, Zaller, D, Pikounis, V.B, O'Keefe, S.J, Scapin, G. 登録日 2003-03-24 公開日 2003-09-02 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity Nat.Struct.Biol., 10, 2003
1OUY	The structure of p38 alpha in complex with a dihydropyrido-pyrimidine inhibitor 分子名称: 1-(2,6-DICHLOROPHENYL)-6-[(2,4-DIFLUOROPHENYL)SULFANYL]-7-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-3,4-DIHYDROPYRIDO[3,2-D]PYRIMIDIN-2(1H)-ONE, Mitogen-activated protein kinase 14 著者 Fitzgerald, C.E, Patel, S.B, Becker, J.W, Cameron, P.M, Zaller, D, Pikounis, V.B, O'Keefe, S.J, Scapin, G. 登録日 2003-03-25 公開日 2003-09-02 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity Nat.Struct.Biol., 10, 2003
4WK8	FOXP3 forms a domain-swapped dimer to bridge DNA 分子名称: DNA (5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3'), Forkhead box protein P3 著者 Chen, Y, Chen, L. 登録日 2014-10-01 公開日 2015-01-21 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.4006 Å) 主引用文献 DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions. Nucleic Acids Res., 43, 2015
5M54	Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins 分子名称: Calmodulin-regulated spectrin-associated protein 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Akhmanova, A, Moores, C.A, Baldus, M, Steinmetz, M.O, Topf, M, Roberts, A.J, Grant, B.J, Scarabelli, G, Joseph, A.-J, van Hooff, J.J.E, Houben, K, Hua, S, Luo, Y, Stangier, M.M, Jiang, K, Atherton, J. 登録日 2016-10-20 公開日 2017-10-04 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (8 Å) 主引用文献 A structural model for microtubule minus-end recognition and protection by CAMSAP proteins. Nat. Struct. Mol. Biol., 24, 2017
1NVO	Solution structure of a four-helix bundle model, apo-DF1 分子名称: Homodimeric Alpha2 Four-Helix Bundle 著者 Maglio, O, Nastri, F, Pavone, V, Lombardi, A, DeGrado, W.F. 登録日 2003-02-04 公開日 2003-03-25 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Preorganization of molecular binding sites in designed diiron proteins Proc.Natl.Acad.Sci.USA, 100, 2003
5ND4	Microtubule-bound MKLP2 motor domain in the presence of ADP.AlFx 分子名称: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Atherton, J, Yu, I.-M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A. 登録日 2017-03-07 公開日 2017-10-04 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry. Elife, 6, 2017
4Z7Q	Integrin alphaIIbbeta3 in complex with AGDV-NH2 peptide 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Lin, F.-Y, Zhu, J, Springer, T.A. 登録日 2015-04-07 公開日 2015-12-16 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 beta-Subunit Binding Is Sufficient for Ligands to Open the Integrin alpha IIb beta 3 Headpiece. J.Biol.Chem., 291, 2016
5ND2	Microtubule-bound MKLP2 motor domain in the presence of ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Atherton, J, Yu, I.M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A. 登録日 2017-03-07 公開日 2017-10-04 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (5.8 Å) 主引用文献 The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry. Elife, 6, 2017
1QE6	INTERLEUKIN-8 WITH AN ADDED DISULFIDE BETWEEN RESIDUES 5 AND 33 (L5C/H33C) 分子名称: INTERLEUKIN-8 VARIANT, SULFATE ION 著者 Gerber, N, Lowman, H, Artis, D.R, Eigenbrot, C. 登録日 1999-07-13 公開日 2000-03-22 最終更新日 2018-01-31 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Receptor-binding conformation of the "ELR" motif of IL-8: X-ray structure of the L5C/H33C variant at 2.35 A resolution. Proteins, 38, 2000
4X0K	Engineered Fab fragment specific for EYMPME (EE) peptide 分子名称: Fab fragment heavy chain, Fab fragment light chain 著者 Johnson, J.L, Lieberman, R.L. 登録日 2014-11-21 公開日 2015-04-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization. Acta Crystallogr.,Sect.D, 71, 2015
4WZ8	Crystal structure of human-yeast chimera acetyl coA carboxylase CT domain bound to Compound 6 分子名称: 1'-(2H-indazol-5-ylcarbonyl)-1-(propan-2-yl)-1,4-dihydrospiro[indazole-5,4'-piperidin]-7(6H)-one, Acetyl-CoA carboxylase 著者 Vajdos, F.F. 登録日 2014-11-18 公開日 2014-12-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes. J.Med.Chem., 57, 2014
4ZNB	METALLO-BETA-LACTAMASE (C181S MUTANT) 分子名称: METALLO-BETA-LACTAMASE, SODIUM ION, ZINC ION 著者 Li, Z, Herzberg, O. 登録日 1998-10-20 公開日 1999-06-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structural consequences of the active site substitution Cys181 --> Ser in metallo-beta-lactamase from Bacteroides fragilis. Protein Sci., 8, 1999
4WZ6	Human CFTR aa389-678 (NBD1), deltaF508 with three solubilizing mutations, bound ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION 著者 Byrnes, L.J, Hall, J. 登録日 2014-11-18 公開日 2015-11-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy. Protein Sci., 25, 2016
1N0A	Turn stability in beta-hairpin peptides: 3:5 type I G1 bulge turns 分子名称: bhpw_pdg, beta-hairpin peptide 著者 Blandl, T, Cochran, A.G, Skelton, N.J. 登録日 2002-10-11 公開日 2003-10-21 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Turn stability in beta-hairpin peptides: Investigation of peptides containing 3:5 type I G1 bulge turns PROTEIN SCI., 12, 2003
5ND3	Microtubule-bound MKLP2 motor domain in the with no nucleotide 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF20A, ... 著者 Atherton, J, Yu, I.M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A. 登録日 2017-03-07 公開日 2017-10-04 実験手法 ELECTRON MICROSCOPY (6.1 Å) 主引用文献 The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry. Elife, 6, 2017
4Y7N	The Structure Insight into 5-Carboxycytosine Recognition by RNA Polymerase II during Transcription Elongation. 分子名称: DNA (29-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... 著者 Wang, L, Chong, J, Wang, D. 登録日 2015-02-15 公開日 2015-07-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature, 523, 2015

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