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7YXB
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MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange
分子名称: 1,2-ETHANEDIOL, CITRATE ANION, CLIP peptide, ...
著者Roske, Y, Abualrous, E.T, Freund, C.
登録日2022-02-15
公開日2023-02-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.095 Å)
主引用文献MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Nat.Chem.Biol., 19, 2023
7Z0Q
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MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange
分子名称: 1,2-ETHANEDIOL, CLIP peptide, HLA class II histocompatibility antigen, ...
著者Roske, Y, Abualrous, E.T, Freund, C.
登録日2022-02-23
公開日2023-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Nat.Chem.Biol., 19, 2023
6RTG
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Crystal structure of the UDP-bound glycosyltransferase domain from the YGT toxin
分子名称: 1,2-ETHANEDIOL, MANGANESE (II) ION, POTASSIUM ION, ...
著者Wirth, C, Bogdanovic, X, Kao, W.-C, Hunte, C.
登録日2019-05-23
公開日2020-03-18
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Inverse control of Rab proteins byYersiniaADP-ribosyltransferase and glycosyltransferase related to clostridial glucosylating toxins.
Sci Adv, 6, 2020
5FUQ
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CRYSTAL STRUCTURE OF THE H80R VARIANT OF NQO1 BOUND TO DICOUMAROL
分子名称: ACETATE ION, BISHYDROXY[2H-1-BENZOPYRAN-2-ONE,1,2-BENZOPYRONE], FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Gavira, J.A, Medina-Carmona, E, Pey, A.L.
登録日2016-01-29
公開日2017-02-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution.
Hum.Mol.Genet., 26, 2017
7QAC
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BU of 7qac by Molmil
The T2 structure of polycrystalline cubic human insulin
分子名称: Insulin A chain, Insulin B chain
著者Karavassili, F, Triandafillidis, D.P, Valmas, A, Spiliopoulou, M, Fili, S, Kontou, P, Bowler, M.W, Von Dreele, R.B, Fitch, A, Margiolaki, I.
登録日2021-11-16
公開日2023-06-21
最終更新日2024-02-07
実験手法POWDER DIFFRACTION (2.29 Å)
主引用文献The T 2 structure of polycrystalline cubic human insulin.
Acta Crystallogr D Struct Biol, 79, 2023
1UVO
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Structure Of The Complex Of Porcine Pancreatic Elastase In Complex With Cadmium Refined At 1.85 A Resolution (Crystal A)
分子名称: ACETATE ION, CADMIUM ION, CHLORIDE ION, ...
著者Weiss, M.S, Panjikar, S, Mueller-Dieckmann, C, Tucker, P.A.
登録日2004-01-21
公開日2004-02-10
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献On the Influence of the Incident Photon Energy on the Radiation Damage in Crystalline Biological Samples
J.Synchrotron Radiat., 12, 2005
1UO6
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BU of 1uo6 by Molmil
PORCINE PANCREATIC ELASTASE/Xe-COMPLEX
分子名称: CHLORIDE ION, ELASTASE 1, GLYCEROL, ...
著者Mueller-Dieckmann, C, Polentarutti, M, Djinovic-Carugo, K, Panjikar, S, Tucker, P.A, Weiss, M.S.
登録日2003-09-16
公開日2003-10-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献On the Routine Use of Soft X-Rays in Macromolecular Crystallography. Part II. Data-Collection Wavelength and Scaling Models
Acta Crystallogr.,Sect.D, 60, 2004
1UVP
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BU of 1uvp by Molmil
Structure Of The Complex Of Porcine Pancreatic Elastase In Complex With Cadmium Refined At 1.85 A Resolution (Crystal B)
分子名称: ACETATE ION, CADMIUM ION, CHLORIDE ION, ...
著者Weiss, M.S, Panjikar, S, Mueller-Dieckmann, C, Tucker, P.A.
登録日2004-01-21
公開日2004-02-10
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献On the Influence of the Incident Photon Energy on the Radiation Damage in Crystalline Biological Samples
J.Synchrotron Radiat., 12, 2005
8VZ7
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BU of 8vz7 by Molmil
Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan
分子名称: Cytochrome P450 2C9, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Shah, M.B.
登録日2024-02-11
公開日2024-06-12
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Structural and biophysical analysis of cytochrome P450 2C9*14 and *27 variants in complex with losartan.
J.Inorg.Biochem., 258, 2024
1AIX
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BU of 1aix by Molmil
HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROVAL
分子名称: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUGEN, ...
著者Skordalakes, E, Dodson, G, Elgendy, S, Goodwin, C.A, Green, D, Tyrrel, R, Scully, M.F, Freyssinet, J, Kakkar, V.V, Deadman, J.
登録日1997-04-30
公開日1997-10-15
最終更新日2013-03-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.
Protein Sci., 1, 1992
8VX0
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BU of 8vx0 by Molmil
CRYSTAL STRUCTURE OF CYP2C9*14 IN COMPLEX WITH LOSARTAN
分子名称: Cytochrome P450 2C9, PHOSPHATE ION, POTASSIUM ION, ...
著者Shah, M.B.
登録日2024-02-02
公開日2024-06-12
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Structural and biophysical analysis of cytochrome P450 2C9*14 and *27 variants in complex with losartan.
J.Inorg.Biochem., 258, 2024
1AI8
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BU of 1ai8 by Molmil
HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH THE EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROMPG
分子名称: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUDIN IIIB, ...
著者Skordalakes, E, Dodson, G, Elgendy, S, Goodwin, C.A, Green, D, Tyrrel, R, Scully, M.F, Freyssinet, J, Kakkar, V.V, Deadman, J.
登録日1997-05-01
公開日1997-10-15
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.
Protein Sci., 1, 1992
7N0H
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CryoEM structure of SARS-CoV-2 spike protein (S-6P, 2-up) in complex with sybodies (Sb45)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Jiang, J, Huang, R, Margulies, D.
登録日2021-05-25
公開日2021-06-02
最終更新日2021-10-20
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献Structures of synthetic nanobody-SARS-CoV-2 receptor-binding domain complexes reveal distinct sites of interaction.
J.Biol.Chem., 297, 2021
7N0G
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BU of 7n0g by Molmil
CryoEm structure of SARS-CoV-2 spike protein (S-6P, 1-up) in complex with sybodies (Sb45)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Jiang, J, Huang, R, Margulies, D.
登録日2021-05-25
公開日2021-06-02
最終更新日2021-10-20
実験手法ELECTRON MICROSCOPY (3.02 Å)
主引用文献Structures of synthetic nanobody-SARS-CoV-2 receptor-binding domain complexes reveal distinct sites of interaction.
J.Biol.Chem., 297, 2021
6DWF
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BU of 6dwf by Molmil
Crystal structure of complex of BBKI mutant, L55R with Bovine Trypsin
分子名称: Cationic trypsin, Kunitz-type inihibitor
著者Li, M, Wlodawer, A, Gustchina, A.
登録日2018-06-26
公開日2019-01-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes.
Acta Crystallogr D Struct Biol, 75, 2019
7N7I
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BU of 7n7i by Molmil
X-ray crystal structure of Viperin-like enzyme from Trichoderma virens
分子名称: IRON/SULFUR CLUSTER, S-ADENOSYLMETHIONINE, URIDINE 5'-TRIPHOSPHATE, ...
著者Grove, T.L, Almo, S.C, Bonanno, J.B, Lachowicz, J.C, Gizzi, A.G.
登録日2021-06-10
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Structural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life.
Biochemistry, 60, 2021
7N7H
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X-ray crystal structure of Viperin-like enzyme from Nematostella vectensis
分子名称: CYTIDINE-5'-TRIPHOSPHATE, IRON/SULFUR CLUSTER, S-ADENOSYLMETHIONINE, ...
著者Grove, T.L, Almo, S.C, Bonanno, J.B, Lachowicz, J.C, Gizzi, A.G.
登録日2021-06-10
公開日2021-07-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Structural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life.
Biochemistry, 60, 2021
6ZX6
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BU of 6zx6 by Molmil
Antiparallel basket-type G-quadruplex DNA structure formed in human Bcl-2 promoter containing 8-oxoG
分子名称: bcl2ex-oxoG19
著者Bielskute, S, Plavec, J, Podbevsek, P.
登録日2020-07-29
公開日2021-03-10
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Oxidative lesions modulate G-quadruplex stability and structure in the human BCL2 promoter.
Nucleic Acids Res., 49, 2021
6ZX7
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BU of 6zx7 by Molmil
Antiparallel basket-type G-quadruplex DNA structure formed in human Bcl-2 promoter
分子名称: bcl2ex
著者Bielskute, S, Plavec, J, Podbevsek, P.
登録日2020-07-29
公開日2021-03-10
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Oxidative lesions modulate G-quadruplex stability and structure in the human BCL2 promoter.
Nucleic Acids Res., 49, 2021
1MKW
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BU of 1mkw by Molmil
THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
分子名称: ALPHA-THROMBIN, PRETHROMBIN-2
著者Malkowski, M.G, Edwards, B.F.P.
登録日1997-03-13
公開日1997-07-07
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
1ESD
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BU of 1esd by Molmil
THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES
分子名称: ESTERASE, METHYLPHOSPHONIC ACID ESTER GROUP
著者Wei, Y, Schottel, J.L, Derewenda, U, Swenson, L, Patkar, S, Derewenda, Z.S.
登録日1994-10-07
公開日1995-10-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A novel variant of the catalytic triad in the Streptomyces scabies esterase.
Nat.Struct.Biol., 2, 1995
1EL4
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STRUCTURE OF THE CALCIUM-REGULATED PHOTOPROTEIN OBELIN DETERMINED BY SULFUR SAS
分子名称: C2-HYDROXY-COELENTERAZINE, CHLORIDE ION, OBELIN
著者Liu, Z.J, Vysotski, E.S, Rose, J, Lee, J, Wang, B.C.
登録日2000-03-13
公開日2001-03-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Structure of the Ca2+-regulated photoprotein obelin at 1.7 A resolution determined directly from its sulfur substructure.
Protein Sci., 9, 2000
6L4S
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cryo-em structure of alpha-synuclein fiber mutation type E46K
分子名称: Alpha-synuclein
著者Li, Y.W, Zhao, K, Liu, C, Li, X.
登録日2019-10-21
公開日2020-04-29
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.37 Å)
主引用文献Parkinson's disease associated mutation E46K of alpha-synuclein triggers the formation of a distinct fibril structure.
Nat Commun, 11, 2020
1ETS
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BU of 1ets by Molmil
REFINED 2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS NAPAP, 4-TAPAP AND MQPA: A STARTING POINT FOR IMPROVING ANTITHROMBOTICS
分子名称: 1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimidoyl-D-phenylalanyl]piperidine, EPSILON-THROMBIN
著者Bode, W, Brandstetter, H.
登録日1992-07-06
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
J.Mol.Biol., 226, 1992
1N2R
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A natural selected dimorphism in HLA B*44 alters self, peptide reportoire and T cell recognition.
分子名称: ACETIC ACID, Beta-2-microglobulin, HLA DPA*0201 PEPTIDE, ...
著者Macdonald, W.A, Purcell, A.W, Williams, D.S, Mifsud, N, Ely, L.K, Gorman, J.J, Clements, C.S, Kjer-Nielsen, L, Koelle, D.M, Brooks, A.G, Lovrecz, G.O, Lu, L, Rossjohn, J, McCluskey, J.
登録日2002-10-24
公開日2004-03-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition.
J.Exp.Med., 198, 2003

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