1ETS

REFINED 2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS NAPAP, 4-TAPAP AND MQPA: A STARTING POINT FOR IMPROVING ANTITHROMBOTICS

Summary for 1ETS
Related1ETR 1ETT
Related PRD IDPRD_000451
DescriptorEPSILON-THROMBIN, 1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimidoyl-D-phenylalanyl]piperidine, ... (4 entities in total)
Functional Keywordsserine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceBos taurus (cow)
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Cellular locationSecreted, extracellular space: P00735 P00735
Total number of polymer chains2
Total formula weight36029.29
Authors
Bode, W.,Brandstetter, H. (deposition date: 1992-07-06, release date: 1994-01-31, Last modification date: 2012-12-12)
Primary citationBode, W.,Brandstetter, H.,Edwards, B.F.,Grosse, D.,Hoeffken, H.W.,Martin, P.D.,Sturzebecher, J.,Turk, D.
Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
J.Mol.Biol., 226:1085-1099, 1992
PubMed: 1518046
DOI: 110.1016/0022-2836(92)91054-S
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation
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PDB entries from 2021-06-16