8VZ7
Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan
Summary for 8VZ7
Entry DOI | 10.2210/pdb8vz7/pdb |
Descriptor | Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE, [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol, ... (6 entities in total) |
Functional Keywords | cytochrome p450 2c9*27 genetic variant, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 55873.34 |
Authors | Shah, M.B. (deposition date: 2024-02-11, release date: 2024-06-12, Last modification date: 2024-06-26) |
Primary citation | Parikh, S.J.,Edara, S.,Deodhar, S.,Singh, A.K.,Maekawa, K.,Zhang, Q.,Glass, K.C.,Shah, M.B. Structural and biophysical analysis of cytochrome P450 2C9*14 and *27 variants in complex with losartan. J.Inorg.Biochem., 258:112622-112622, 2024 Cited by PubMed: 38852293DOI: 10.1016/j.jinorgbio.2024.112622 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.53 Å) |
Structure validation
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