8VZ7
Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cytochrome P450 2C9 | polymer | 476 | 54191.8 | 1 | UniProt (P11712) Pfam (PF00067) In PDB | Homo sapiens (human) | (R)-limonene 6-monooxygenase,(S)-limonene 6-monooxygenase,(S)-limonene 7-monooxygenase,CYPIIC9,Cholesterol 25-hydroxylase,Cytochrome P-450MP,Cytochrome P450 MP-4,Cytochrome P450 MP-8,Cytochrome P450 PB-1,S-mephenytoin 4-hydroxylase |
2 | A | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
3 | A | [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol | non-polymer | 422.9 | 2 | Chemie (LSN) | |||
4 | A | beta-D-fructofuranose | non-polymer | 180.2 | 1 | Chemie (FRU) | |||
5 | A | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
6 | water | water | 18.0 | 171 | Chemie (HOH) |
Sequence modifications
A: 24 - 490 (UniProt: P11712)
PDB | External Database | Details |
---|---|---|
Met 19 | - | initiating methionine |
Ala 20 | - | insertion |
Lys 21 | - | insertion |
Lys 22 | - | insertion |
Thr 23 | - | insertion |
Leu 150 | Arg 150 | engineered mutation |
Ile 490 | Val 490 | engineered mutation |
His 491 | - | expression tag |
His 492 | - | expression tag |
His 493 | - | expression tag |
His 494 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 54191.8 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1681.6 | |
All* | Total formula weight | 55873.3 |