3SVG
| Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand | 分子名称: | (1R)-1-[3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-ethoxyphenyl]ethanol, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 | 著者 | Filippakopoulos, P, Picaud, S, Felletar, I, Hewings, S.D, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Conway, S.J, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2011-07-12 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand TO BE PUBLISHED
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3PSL
| Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3 based peptide mimetic | 分子名称: | N-alpha acetylated form of histone H3, WD repeat-containing protein 5 | 著者 | Avdic, V, Zhang, P, Lanouette, S, Voronova, A, Skerjanc, I, Couture, J.-F. | 登録日 | 2010-12-01 | 公開日 | 2010-12-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic. Faseb J., 25, 2011
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3QBY
| Crystal structure of the PWWP domain of human Hepatoma-derived growth factor 2 | 分子名称: | H4K20me3 Histone H4 Peptide, Hepatoma-derived growth factor-related protein 2, SULFATE ION, ... | 著者 | Zeng, H, Tempel, W, Amaya, M.F, Adams-Cioaba, M.A, Mackenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-01-14 | 公開日 | 2011-02-09 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural and Histone Binding Ability Characterizations of Human PWWP Domains. Plos One, 6, 2011
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3THX
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3THY
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3T1I
| Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Double-strand break repair protein MRE11A, GLYCEROL, ... | 著者 | Park, Y.B, Chae, J, Kim, Y, Cho, Y. | 登録日 | 2011-07-22 | 公開日 | 2011-11-30 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of human mre11: understanding tumorigenic mutations Structure, 19, 2011
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3TBL
| Structure of Mono-ubiquitinated PCNA: Implications for DNA Polymerase Switching and Okazaki Fragment Maturation | 分子名称: | Proliferating cell nuclear antigen, Ubiquitin | 著者 | Zhang, Z, Lee, M, Lee, E, Zhang, S. | 登録日 | 2011-08-07 | 公開日 | 2012-05-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.903 Å) | 主引用文献 | Structure of monoubiquitinated PCNA: Implications for DNA polymerase switching and Okazaki fragment maturation. Cell Cycle, 11, 2012
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3THW
| Human MutSbeta complexed with an IDL of 4 bases (Loop4) and ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA Loop4 hairpin, DNA mismatch repair protein Msh2, ... | 著者 | Yang, W. | 登録日 | 2011-08-19 | 公開日 | 2011-12-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Mechanism of mismatch recognition revealed by human MutSbeta bound to unpaired DNA loops Nat.Struct.Mol.Biol., 19, 2012
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3UAL
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3THZ
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3U5L
| Crystal Structure of the first bromodomain of human BRD4 in complex with a benzo-triazepine ligand (BzT-7) | 分子名称: | 1,2-ETHANEDIOL, 8-chloro-1,4-dimethyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,3,4]benzotriazepine, Bromodomain-containing protein 4 | 著者 | Filippakopoulos, P, Picaud, S, Felletar, I, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Bracher, F, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2011-10-11 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Bioorg.Med.Chem., 20, 2012
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3R22
| Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I) | 分子名称: | N-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamide, Serine/threonine-protein kinase 6 | 著者 | Zhang, L, Fan, J, Chong, J.-H, Cesana, A, Tam, B, Gilson, C, Boykin, C, Wang, D, Marcotte, D, Le Brazidec, J.-Y, Aivazian, D, Piao, J, Lundgren, K, Hong, K, Vu, K, Nguyen, K. | 登録日 | 2011-03-11 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I). Bioorg.Med.Chem.Lett., 21, 2011
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3RNU
| Structural Basis of Cytosolic DNA Sensing by Innate Immune Receptors | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*CP*AP*TP*CP*AP*AP*AP*GP*AP*GP*AP*GP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*CP*TP*CP*TP*TP*TP*GP*AP*TP*GP*GP*CP*C)-3'), ... | 著者 | Jin, T.C, Xiao, T. | 登録日 | 2011-04-22 | 公開日 | 2012-04-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.502 Å) | 主引用文献 | Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor. Immunity, 36, 2012
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3SAH
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3SAG
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3SHV
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3S92
| Crystal Structure of the second bromodomain of human BRD3 in complex with the inhibitor JQ1 | 分子名称: | (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, 1,2-ETHANEDIOL, Bromodomain-containing protein 3 | 著者 | Filippakopoulos, P, Picaud, S, Qi, J, Keates, T, Felletar, I, Fedorov, O, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Bradner, J.E, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2011-05-31 | 公開日 | 2011-06-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Crystal Structure of the second bromodomain of human BRD3 in complex with the inhibitor JQ1 To be Published
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3U5K
| Crystal Structure of the first bromodomain of human BRD4 in complex with Midazolam | 分子名称: | 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine, Bromodomain-containing protein 4 | 著者 | Filippakopoulos, P, Picaud, S, Felletar, I, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2011-10-11 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Bioorg.Med.Chem., 20, 2012
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3TIW
| Crystal structure of p97N in complex with the C-terminus of gp78 | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase AMFR, Transitional endoplasmic reticulum ATPase | 著者 | Haenzelmann, P, Schindelin, H. | 登録日 | 2011-08-22 | 公開日 | 2011-09-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | 主引用文献 | The Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM): MUTUALLY EXCLUSIVE BINDING OF COFACTORS TO THE N-TERMINAL DOMAIN OF p97. J.Biol.Chem., 286, 2011
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3U1N
| Structure of the catalytic core of human SAMHD1 | 分子名称: | PHOSPHATE ION, SAM domain and HD domain-containing protein 1, ZINC ION | 著者 | Goldstone, D.C, Ennis-Adeniran, V, Walker, P.A, Haire, L.F, Webb, M, Taylor, I.A. | 登録日 | 2011-09-30 | 公開日 | 2011-11-16 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase Nature, 480, 2011
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3Q6S
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3U5J
| Crystal Structure of the first bromodomain of human BRD4 in complex with Alprazolam | 分子名称: | 1,2-ETHANEDIOL, 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, Bromodomain-containing protein 4 | 著者 | Filippakopoulos, P, Picaud, S, Felletar, I, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2011-10-11 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Bioorg.Med.Chem., 20, 2012
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3TJM
| Crystal Structure of the Human Fatty Acid Synthase Thioesterase Domain with an Activate Site-Specific Polyunsaturated Fatty Acyl Adduct | 分子名称: | Fatty acid synthase, methyl (R)-(6Z,9Z,12Z)-octadeca-6,9,12-trien-1-ylphosphonofluoridate | 著者 | Zhang, W, Zheng, F, Florante, A.Q. | 登録日 | 2011-08-24 | 公開日 | 2011-09-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TLP
| Crystal structure of the fourth bromodomain of human poly-bromodomain containing protein 1 (PB1) | 分子名称: | NICKEL (II) ION, Protein polybromo-1 | 著者 | Filippakopoulos, P, Felletar, I, Picaud, S, Keates, T, Muniz, J, Krojer, T, Allerston, C.K, Latwiel, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2011-08-30 | 公開日 | 2011-09-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149, 2012
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3TYT
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