3TJM

Crystal Structure of the Human Fatty Acid Synthase Thioesterase Domain with an Activate Site-Specific Polyunsaturated Fatty Acyl Adduct

Summary for 3TJM

Entry DOI	10.2210/pdb3tjm/pdb
Descriptor	Fatty acid synthase, methyl (R)-(6Z,9Z,12Z)-octadeca-6,9,12-trien-1-ylphosphonofluoridate (3 entities in total)
Functional Keywords	thioesterase domain, fatty acid synthesis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	31315.49
Authors	Zhang, W.,Zheng, F.,Florante, A.Q. (deposition date: 2011-08-24, release date: 2011-09-28, Last modification date: 2023-09-13)
Primary citation	Zhang, W.,Chakravarty, B.,Zheng, F.,Gu, Z.,Wu, H.,Mao, J.,Wakil, S.J.,Quiocho, F.A. Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid. Proc.Natl.Acad.Sci.USA, 108:15757-15762, 2011 Cited by PubMed: 21908709 DOI: 10.1073/pnas.1112334108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.48 Å)

Structure validation