3TJM
Crystal Structure of the Human Fatty Acid Synthase Thioesterase Domain with an Activate Site-Specific Polyunsaturated Fatty Acyl Adduct
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fatty acid synthase | polymer | 283 | 30971.0 | 1 | UniProt (P49327) Pfam (PF00975) | Homo sapiens (human) | [Acyl-carrier-protein] S-acetyltransferase, [Acyl-carrier-protein] S-malonyltransferase, 3-oxoacyl-[acyl-carrier-protein] synthase, 3-oxoacyl-[acyl-carrier-protein] reductase, 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, Enoyl-[acyl-carrier-protein] reductase, Oleoyl-[acyl-carrier-protein] hydrolase |
| 2 | B (A) | methyl (R)-(6Z,9Z,12Z)-octadeca-6,9,12-trien-1-ylphosphonofluoridate | non-polymer | 344.4 | 1 | Chemie (7FA) | |||
| 3 | C (A) | water | water | 18.0 | 251 | Chemie (HOH) |
Sequence modifications
A: 2218 - 2500 (UniProt: P49327)
| PDB | External Database | Details |
|---|---|---|
| Gly 2349 | Gln 2349 | conflict |
| Ala 2457 | Asp 2457 | conflict |
| Ala 2458 | Leu 2458 | conflict |
| Ala 2482 | Arg 2482 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30971.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 344.4 | |
| All* | Total formula weight | 31315.5 |
