7VCI
| Structure of Xenopus laevis NPC nuclear ring asymmetric unit | 分子名称: | GATOR complex protein SEC13, MGC154553 protein, MGC83295 protein, ... | 著者 | Tai, L, Zhu, Y, Sun, F. | 登録日 | 2021-09-03 | 公開日 | 2022-02-02 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (8.1 Å) | 主引用文献 | 8 angstrom structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI. Protein Cell, 13, 2022
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4ABZ
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4S0Z
| Crystal structure of M26V human DJ-1 | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Protein DJ-1 | 著者 | Milkovic, N.M, Wilson, M.A. | 登録日 | 2015-01-07 | 公開日 | 2015-08-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature. Protein Sci., 24, 2015
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4TL1
| GCN4-p1 with mutation to 1-Aminocyclohexanecarboxylic acid at residue 10 | 分子名称: | General control protein GCN4, ISOPROPYL ALCOHOL | 著者 | Tavenor, N.A, Silva, K.I, Saxena, S, Horne, W.S. | 登録日 | 2014-05-28 | 公開日 | 2014-08-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Origins of Structural Flexibility in Protein-Based Supramolecular Polymers Revealed by DEER Spectroscopy. J.Phys.Chem.B, 118, 2014
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8BHF
| Cryo-EM structure of stalled rabbit 80S ribosomes in complex with human CCR4-NOT and CNOT4 | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S11, ... | 著者 | Absmeier, E, Chandrasekaran, V, O'Reilly, F.J, Stowell, J.A.W, Rappsilber, J, Passmore, L.A. | 登録日 | 2022-10-31 | 公開日 | 2023-09-06 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
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8P2K
| Ternary complex of translating ribosome, NAC and METAP1 | 分子名称: | 18s rRNA, 28S rRNA, 40S ribosomal protein S11, ... | 著者 | Jia, M, Jaskolowski, M, Scaiola, A, Jomaa, A, Ban, N. | 登録日 | 2023-05-16 | 公開日 | 2023-07-19 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | NAC controls cotranslational N-terminal methionine excision in eukaryotes. Science, 380, 2023
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7NVQ
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8CUR
| Crystal structure of Cdk2 in complex with Cyclin A inhibitor 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid | 分子名称: | 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid, Cyclin-dependent kinase 2 | 著者 | Tripathi, S.M, Tambo, C.S, Kiss, G, Rubin, S.M. | 登録日 | 2022-05-17 | 公開日 | 2023-04-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics. Acs Chem.Biol., 18, 2023
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8ERN
| Cyclin-free CDK2 in complex with Cpd21 | 分子名称: | Cyclin-dependent kinase 2, GLYCEROL, N,3-dimethyl-4-({7-[(2S)-2-methylpyrrolidine-1-carbonyl]quinazolin-2-yl}amino)benzene-1-sulfonamide | 著者 | Murray, J.M, Oh, A. | 登録日 | 2022-10-12 | 公開日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Cyclin-free CDK2 in complex with Cpd21 To Be Published
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8ERD
| Cyclin-free CDK2 in complex with Cpd17 | 分子名称: | (2-{[1-(methanesulfonyl)piperidin-4-yl]amino}quinazolin-7-yl)[(2S)-2-methylpyrrolidin-1-yl]methanone, Cyclin-dependent kinase 2 | 著者 | Murray, J.M, Oh, A. | 登録日 | 2022-10-11 | 公開日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Cyclin-free CDK2 in complex with Cpd17 To Be Published
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5IEX
| Crystal structure of (R,S)-S-{4-[(5-Bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}- pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide bound to CDK2 | 分子名称: | (2R,3R)-3-[(5-bromo-2-{[4-(S-cyclopropylsulfonimidoyl)phenyl]amino}pyrimidin-4-yl)oxy]butan-2-ol, Cyclin-dependent kinase 2 | 著者 | Ayaz, P, Andres, D, Kwiatkowski, D.A, Kolbe, C, Lienau, P, Siemeister, G, Luecking, U, Stegmann, C.M. | 登録日 | 2016-02-25 | 公開日 | 2016-04-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9. Acs Chem.Biol., 11, 2016
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3VEP
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3F72
| Crystal Structure of the Staphylococcus aureus pI258 CadC Metal Binding Site 2 Mutant | 分子名称: | Cadmium efflux system accessory protein, SODIUM ION | 著者 | Kandegedara, A, Thiyagarajan, S, Kondapalli, K.C, Stemmler, T.L, Rosen, B.P. | 登録日 | 2008-11-07 | 公開日 | 2009-04-07 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Role of bound Zn(II) in the CadC Cd(II)/Pb(II)/Zn(II)-responsive repressor. J.Biol.Chem., 284, 2009
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3DSH
| Crystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domain | 分子名称: | Interferon regulatory factor 5 | 著者 | Chen, W, Lam, S.S, Srinath, H, Jiang, Z, Correia, J.J, Schiffer, C, Fitzgerald, K.A, Lin, K, Royer Jr, W.E. | 登録日 | 2008-07-12 | 公開日 | 2008-10-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat.Struct.Mol.Biol., 15, 2008
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5IF1
| Crystal structure apo CDK2/cyclin A | 分子名称: | Cyclin-A2, Cyclin-dependent kinase 2 | 著者 | Ayaz, P, Andres, D, Kwiatkowski, D.A, Kolbe, C, Lienau, P, Siemeister, G, Luecking, U, Stegmann, C.M. | 登録日 | 2016-02-25 | 公開日 | 2016-04-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9. Acs Chem.Biol., 11, 2016
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5IEV
| Crystal structure of BAY 1000394 (Roniciclib) bound to CDK2 | 分子名称: | Cyclin-dependent kinase 2, Roniciclib | 著者 | Ayaz, P, Andres, D, Kwiatkowski, D.A, Kolbe, C, Lienau, P, Siemeister, G, Luecking, U, Stegmann, C.M. | 登録日 | 2016-02-25 | 公開日 | 2016-04-27 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9. Acs Chem.Biol., 11, 2016
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5VTB
| Crystal structure of RBBP4 bound to BCL11a peptide | 分子名称: | B-cell lymphoma/leukemia 11A, GLYCEROL, Histone-binding protein RBBP4 | 著者 | Meagher, J.L, Stuckey, J.A. | 登録日 | 2017-05-16 | 公開日 | 2017-12-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes. J. Biol. Chem., 293, 2018
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3EGQ
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2OQR
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8I2K
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2WQI
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7RG4
| Importin alpha2 in complex with p50 NLS | 分子名称: | Importin subunit alpha-1, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit | 著者 | Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K. | 登録日 | 2021-07-14 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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7RG5
| Importin alpha3 in complex with p50 NLS | 分子名称: | Importin subunit alpha-3, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit | 著者 | Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K. | 登録日 | 2021-07-14 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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7MDZ
| 80S rabbit ribosome stalled with benzamide-CHX | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S21, ... | 著者 | Koga, Y, Hoang, E.M, Park, Y, Keszei, A.F.A, Murray, J, Shao, S, Liau, B.B. | 登録日 | 2021-04-06 | 公開日 | 2021-09-01 | 最終更新日 | 2021-09-15 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation. J.Am.Chem.Soc., 143, 2021
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2WQ3
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