8CUR

Crystal structure of Cdk2 in complex with Cyclin A inhibitor 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid

Summary for 8CUR

Entry DOI	10.2210/pdb8cur/pdb
Descriptor	Cyclin-dependent kinase 2, 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid (3 entities in total)
Functional Keywords	cell cycle, protein-inhibitor complex, kinase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34507.44
Authors	Tripathi, S.M.,Tambo, C.S.,Kiss, G.,Rubin, S.M. (deposition date: 2022-05-17, release date: 2023-04-05, Last modification date: 2023-10-25)
Primary citation	Tambo, C.S.,Tripathi, S.,Perera, B.G.K.,Maly, D.J.,Bridges, A.J.,Kiss, G.,Rubin, S.M. Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics. Acs Chem.Biol., 18:431-440, 2023 Cited by PubMed: 36724382 DOI: 10.1021/acschembio.3c00015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation