7TVK
 
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6UIH
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6NRX
 | | Crystal structure of DIP-eta IG1 homodimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Dpr-interacting protein eta, isoform B, ... | | 著者 | Cheng, S, Park, Y.J, Kurleto, J.D, Ozkan, E. | | 登録日 | 2019-01-24 | | 公開日 | 2019-02-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila.
Elife, 8, 2019
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6NRW
 | | Crystal structure of Dpr1 IG1 bound to DIP-eta IG1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Cheng, S, Park, Y.J, Kurleto, J.D, Ozkan, E. | | 登録日 | 2019-01-24 | | 公開日 | 2019-02-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila.
Elife, 8, 2019
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6NRQ
 | | Crystal structure of Dpr10 IG1 bound to DIP-alpha IG1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Defective proboscis extension response 10, isoform A, ... | | 著者 | Cheng, S, Park, Y.J, Kurleto, J.D, Ozkan, E. | | 登録日 | 2019-01-24 | | 公開日 | 2019-02-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila.
Elife, 8, 2019
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6NS1
 | | Crystal structure of DIP-gamma IG1+IG2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Dpr-interacting protein gamma | | 著者 | Cheng, S, Park, Y.J, Kurleto, J.D, Ozkan, E. | | 登録日 | 2019-01-24 | | 公開日 | 2019-02-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila.
Elife, 8, 2019
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6SNQ
 | | Crystal structures of human PGM1 isoform 2 | | 分子名称: | 6-O-phosphono-alpha-D-glucopyranose, Phosphoglucomutase-1, ZINC ION | | 著者 | Backe, P.H, Laerdahl, J.K, Kittelsen, L.S, Dalhus, B, Morkrid, L, Bjoras, M. | | 登録日 | 2019-08-27 | | 公開日 | 2020-04-08 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the alpha-D-phosphohexomutase superfamily.
Sci Rep, 10, 2020
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1JPM
 | | L-Ala-D/L-Glu Epimerase | | 分子名称: | GLYCEROL, L-Ala-D/L-Glu Epimerase, MAGNESIUM ION | | 著者 | Gulick, A.M, Schmidt, D.M.Z, Gerlt, J.A, Rayment, I. | | 登録日 | 2001-08-02 | | 公開日 | 2001-12-21 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Evolution of enzymatic activities in the enolase superfamily: crystal structures of the L-Ala-D/L-Glu epimerases from Escherichia coli and Bacillus subtilis.
Biochemistry, 40, 2001
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6SNO
 | | Crystal structures of human PGM1 isoform 2 | | 分子名称: | 1-O-phosphono-alpha-D-glucopyranose, Phosphoglucomutase-1, ZINC ION | | 著者 | Backe, P.H, Laerdahl, J.K, Kittelsen, L.S, Dalhus, B, Morkrid, L, Bjoras, M. | | 登録日 | 2019-08-27 | | 公開日 | 2020-04-08 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the alpha-D-phosphohexomutase superfamily.
Sci Rep, 10, 2020
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2ODA
 | | Crystal Structure of PSPTO_2114 | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Hypothetical protein PSPTO_2114, MAGNESIUM ION | | 著者 | Peisach, E, Allen, K.N, Dunaway-Mariano, D, Wang, L, Burroughs, A.M, Aravind, L. | | 登録日 | 2006-12-22 | | 公開日 | 2007-09-04 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The X-ray crystallographic structure and activity analysis of a Pseudomonas-specific subfamily of the HAD enzyme superfamily evidences a novel biochemical function.
Proteins, 70, 2007
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1JPD
 | | L-Ala-D/L-Glu Epimerase | | 分子名称: | L-Ala-D/L-Glu Epimerase | | 著者 | Gulick, A.M, Schmidt, D.M.Z, Gerlt, J.A, Rayment, I. | | 登録日 | 2001-08-01 | | 公開日 | 2001-12-21 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Evolution of enzymatic activities in the enolase superfamily: crystal structures of the L-Ala-D/L-Glu epimerases from Escherichia coli and Bacillus subtilis.
Biochemistry, 40, 2001
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8BN8
 | | METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM3006 | | 分子名称: | 2-[[4-(6-bromanyl-2~{H}-indazol-4-yl)-1,2,3-triazol-1-yl]methyl]-6-[(4,4-dimethylpiperidin-1-yl)methyl]imidazo[1,2-a]pyridine, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit | | 著者 | Pilka, E.S, Thomas, B, Blackaby, W, Hardick, D, Feeney, K, Ridgill, M, Rotty, B, Rausch, O. | | 登録日 | 2022-11-13 | | 公開日 | 2023-09-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.213 Å) | | 主引用文献 | Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.
Cancer Discov, 13, 2023
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5XD8
 | | Crystal structure analysis of 3,6-anhydro-L-galactonate cycloisomerase | | 分子名称: | 3,6-anhydro-alpha-L-galactonate cycloisomerase, MAGNESIUM ION | | 著者 | Lee, S, Choi, I.-G, Kim, H.-Y. | | 登録日 | 2017-03-27 | | 公開日 | 2017-09-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.505 Å) | | 主引用文献 | Crystal structure analysis of 3,6-anhydro-l-galactonate cycloisomerase suggests emergence of novel substrate specificity in the enolase superfamily
Biochem. Biophys. Res. Commun., 491, 2017
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2VU5
 | | Crystal structure of Pndk from Bacillus anthracis | | 分子名称: | NUCLEOSIDE DIPHOSPHATE KINASE | | 著者 | Misra, G, Aggarwal, A, Dube, D, Zaman, M.S, Singh, Y, Ramachandran, R. | | 登録日 | 2008-05-21 | | 公開日 | 2009-03-10 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of the Bacillus Anthracis Nucleoside Diphosphate Kinase and its Characterization Reveals an Enzyme Adapted to Perform Under Stress Conditions.
Proteins, 76, 2009
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4R90
 | | Anti CD70 Llama glama Fab 27B3 | | 分子名称: | Anti CD70 Llama glama Fab 27B3 Heavy chain, Anti CD70 Llama glama Fab 27B3 Light chain, CALCIUM ION, ... | | 著者 | Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I. | | 登録日 | 2014-09-03 | | 公開日 | 2015-06-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.746 Å) | | 主引用文献 | Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
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4R96
 | | Structure of a Llama Glama Fab 48A2 against human cMet | | 分子名称: | Llama glama Fab 48A2 against human cMet H chain, Llama glama Fab 48A2 against human cMet L chain | | 著者 | Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I. | | 登録日 | 2014-09-03 | | 公開日 | 2015-06-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | | 主引用文献 | Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
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8TBF
 | | Tricomplex of RMC-7977, KRAS WT, and CypA | | 分子名称: | (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, 1,2-ETHANEDIOL, GTPase KRas, ... | | 著者 | Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K. | | 登録日 | 2023-06-28 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Nature, 629, 2024
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6PPC
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8TZZ
 | | SpG Cas9 with NGC PAM DNA target | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(P*CP*GP*TP*TP*TP*GP*TP*AP*CP*TP*GP*CP*AP*GP*CP*G)-3'), DNA (5'-D(P*TP*CP*TP*CP*AP*TP*CP*TP*TP*TP*AP*TP*GP*CP*GP*TP*C)-3'), ... | | 著者 | Bravo, J.P.K, Hibshman, G.N, Taylor, D.W. | | 登録日 | 2023-08-28 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | | 主引用文献 | Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
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8T7S
 | | SpRYmer bound to NAC PAM DNA | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, NTS, ... | | 著者 | Hibshman, G.N, Bravo, J.P.K, Taylor, D.W. | | 登録日 | 2023-06-21 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
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8U3Y
 | | SpG Cas9 with NGG PAM DNA target | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(P*CP*GP*TP*TP*TP*GP*TP*AP*CP*TP*CP*CP*AP*GP*CP*G)-3'), DNA (5'-D(P*TP*CP*TP*CP*AP*TP*CP*TP*TP*TP*AP*TP*GP*CP*GP*TP*C)-3'), ... | | 著者 | Bravo, J.P.K, Hibshman, G.N, Taylor, D.W. | | 登録日 | 2023-09-08 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
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8T78
 | | SpRY-Cas9:gRNA complex bound to non-target DNA with 8 bp R-loop | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ... | | 著者 | Hibshman, G.N, Bravo, J.P.K, Taylor, D.W. | | 登録日 | 2023-06-19 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
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8T79
 | | SpRY-Cas9:gRNA complex bound to non-target DNA with 10 bp R-loop | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ... | | 著者 | Hibshman, G.N, Bravo, J.P.K, Taylor, D.W. | | 登録日 | 2023-06-20 | | 公開日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
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1A7C
 | | HUMAN PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 IN COMPLEX WITH A PENTAPEPTIDE | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-D-ribopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PENTAPEPTIDE, ... | | 著者 | Xue, Y, Inghardt, T, Sjolin, L, Deinum, J. | | 登録日 | 1998-03-12 | | 公開日 | 1999-03-23 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide
Structure, 6, 1998
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6QAJ
 | | Structure of the tripartite motif of KAP1/TRIM28 | | 分子名称: | Endolysin,Transcription intermediary factor 1-beta, ZINC ION | | 著者 | Stoll, G.A, Oda, S, Yu, M, Modis, Y. | | 登録日 | 2018-12-19 | | 公開日 | 2019-07-24 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.901 Å) | | 主引用文献 | Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing.
Proc.Natl.Acad.Sci.USA, 116, 2019
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