PDB: 5653 件ウェブページステータス検索Chemie searchBIRD

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4QQU	Crystal structure of the cobalamin-independent methionine synthase enzyme in a closed conformation 分子名称: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, N-[4-({[(6S)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-gamma-glutamyl-L-gamma-glutamyl-L-glutamic acid, ... 著者 Ubhi, D.K, Robertus, J.D. 登録日 2014-06-29 公開日 2015-01-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 The cobalamin-independent methionine synthase enzyme captured in a substrate-induced closed conformation. J.Mol.Biol., 427, 2015
7BES	CryoEM structure of Mycobacterium tuberculosis UMP Kinase (UMPK) in complex with UDP and UTP 分子名称: URIDINE 5'-TRIPHOSPHATE, URIDINE-5'-DIPHOSPHATE, Uridylate kinase 著者 Bous, J, Trapani, S, Walter, P, Bron, P, Munier-Lehmann, H. 登録日 2020-12-24 公開日 2022-01-12 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.85 Å) 主引用文献 Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target. Febs J., 289, 2022
4R7G	Determination of the formylglycinamide ribonucleotide amidotransferase ammonia pathway by combining 3D-RISM theory with experiment 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Phosphoribosylformylglycinamidine synthase, ... 著者 Tanwar, A.S, Sindhikara, D.J, Hirata, F, Anand, R. 登録日 2014-08-27 公開日 2015-01-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Determination of the formylglycinamide ribonucleotide amidotransferase ammonia pathway by combining 3D-RISM theory with experiment. Acs Chem.Biol., 10, 2015
3EWX	K314A mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, degraded to BMP 分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, Orotidine-5'-phosphate decarboxylase 著者 Heinrich, D, Wittmann, J, Diederichsen, U, Rudolph, M. 登録日 2008-10-16 公開日 2009-04-07 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15, 2009
3FJ6	Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 2 分子名称: (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide, ACETATE ION, Dihydroorotate dehydrogenase, ... 著者 Heikkila, T. 登録日 2008-12-14 公開日 2009-06-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
3G1D	Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with uridine 5'-monophosphate 分子名称: Orotidine 5'-phosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE 著者 Fedorov, A.A, Fedorov, E.V, Chan, K.K, Gerlt, J.A, Almo, S.C. 登録日 2009-01-29 公開日 2009-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization. Biochemistry, 48, 2009
4R52	1.5 angstrom crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase from Cupriavidus metallidurans 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION 著者 Geng, J, Gumpper, R.H, Huo, L, Liu, A. 登録日 2014-08-20 公開日 2016-03-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 1.5 angstrom crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase from Cupriavidus metallidurans To be Published
4IZO	Crystal structure of kinase Phosphoribosylaminoimidazole carboxylase, ATPase subunit from Burkholderia thailandensis 分子名称: Phosphoribosylaminoimidazole carboxylase, ATPase subunit 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2013-01-30 公開日 2013-02-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structure of kinase Phosphoribosylaminoimidazole carboxylase, ATPase subunit from Burkholderia thailandensis To be Published
4YCD	Structure of a single tryptophan mutant of Acetobacter aceti PurE with Y154F 分子名称: 1,2-ETHANEDIOL, ACETATE ION, N5-carboxyaminoimidazole ribonucleotide mutase, ... 著者 Kappock, T.J, Sullivan, K.L. 登録日 2015-02-19 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.643 Å) 主引用文献 Structure of a single tryptophan mutant of Acetobacter aceti PurE To Be Published
4R5M	Crystal structure of Vc-Aspartate beta-semialdehyde-dehydrogenase with NADP and 4-Nitro-2-Phosphono-Benzoic acid 分子名称: 4-nitro-2-phosphonobenzoic acid, Aspartate-semialdehyde dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Pavlovsky, A.G, Thangavelu, B, Bhansali, P, Viola, R.E. 登録日 2014-08-21 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway. Acta Crystallogr.,Sect.D, 70, 2014
3G3M	Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-iodo-UMP 分子名称: 5-FLUORO-URIDINE-5'-MONOPHOSPHATE, Uridine 5'-monophosphate synthase 著者 Liu, Y, Tang, H.L, Bello, A.M, Poduch, E, Kotra, L.P, Pai, E.F. 登録日 2009-02-02 公開日 2009-03-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J.Med.Chem., 52, 2009
3G0U	Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 4 分子名称: (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... 著者 Davis, M, Heikkila, T, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P. 登録日 2009-01-28 公開日 2009-06-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
3N0V	Crystal structure of a formyltetrahydrofolate deformylase (PP_0327) from PSEUDOMONAS PUTIDA KT2440 at 2.25 A resolution 分子名称: Formyltetrahydrofolate deformylase 著者 Joint Center for Structural Genomics (JCSG) 登録日 2010-05-14 公開日 2010-06-16 最終更新日 2023-02-01 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Crystal structure of a formyltetrahydrofolate deformylase (PP_0327) from PSEUDOMONAS PUTIDA KT2440 at 2.25 A resolution To be published
3G0X	Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 5 分子名称: (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... 著者 Davies, M, Heikkila, T, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P. 登録日 2009-01-29 公開日 2009-06-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
3G18	Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum 分子名称: Orotidine 5'-phosphate decarboxylase 著者 Fedorov, A.A, Fedorov, E.V, Chan, K.K, Gerlt, J.A, Almo, S.C. 登録日 2009-01-29 公開日 2009-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization. Biochemistry, 48, 2009
4RX0	Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM265 分子名称: 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... 著者 Deng, X, Phillips, M, Tomchick, D. 登録日 2014-12-08 公開日 2015-07-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med, 7, 2015
3G3D	Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-azido-UMP 分子名称: 5-FLUORO-URIDINE-5'-MONOPHOSPHATE, GLYCEROL, SULFATE ION, ... 著者 Liu, Y, Tang, H.L, Bello, A, Poduch, E, Kotra, L, Pai, E. 登録日 2009-02-02 公開日 2009-03-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J.Med.Chem., 52, 2009
4YCC	Structure of a single tryptophan mutant of Acetobacter aceti PurE with Y154L mutation 分子名称: 1,2-ETHANEDIOL, ACETATE ION, N5-carboxyaminoimidazole ribonucleotide mutase, ... 著者 Kappock, T.J, Sullivan, K.L. 登録日 2015-02-19 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.257 Å) 主引用文献 Structure of a single tryptophan mutant of Acetobacter aceti PurE To Be Published
7UXH	cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Cui, Z, Hurley, J. 登録日 2022-05-05 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
7UXC	cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex with symmetry expansion 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Cui, Z, Hurley, J. 登録日 2022-05-05 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
3G1A	Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 6-azauridine 5'-monophosphate 分子名称: 6-AZA URIDINE 5'-MONOPHOSPHATE, Orotidine 5'-phosphate decarboxylase 著者 Fedorov, A.A, Fedorov, E.V, Chan, K.K, Gerlt, J.A, Almo, S.C. 登録日 2009-01-29 公開日 2009-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization. Biochemistry, 48, 2009
4Z7J	Structure of Acetobacter aceti PurE-S57A 分子名称: 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, 5-O-phosphono-beta-D-ribofuranose, ... 著者 Kappock, T.J, Sullivan, K.L. 登録日 2015-04-07 公開日 2016-04-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.502 Å) 主引用文献 Mutation of the conserved serine in two PurE classes To Be Published
4ZJY	Structure of Acetobacter aceti PurE-S57N 分子名称: 1,2-ETHANEDIOL, ACETATE ION, BICARBONATE ION, ... 著者 Sullivan, K.L, Kappock, T.J. 登録日 2015-04-29 公開日 2016-05-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.791 Å) 主引用文献 Serine mutants of Acetobacter aceti PurE To be published
4ZMB	Structure of Acetobacter aceti PurE-S57V,Y154F 分子名称: 1,2-ETHANEDIOL, ACETATE ION, N5-carboxyaminoimidazole ribonucleotide mutase, ... 著者 Sullivan, K.L, Kappock, T.J. 登録日 2015-05-02 公開日 2016-05-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.808 Å) 主引用文献 Serine mutants of Acetobacter aceti PurE To be published
4WZC	Understanding Extradiol Dioxygenase Mechanism in NAD+ Biosynthesis by Viewing Catalytic Intermediates - 2,3-cis-4,5-trans ACMS bound to I142A mutant HAO 分子名称: (2E)-2-amino-3-[(1E)-3-oxoprop-1-en-1-yl]but-2-enedioic acid, 3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION 著者 Liu, F, Liu, A. 登録日 2014-11-19 公開日 2016-02-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.842 Å) 主引用文献 Probing Extradiol Dioxygenase Mechanism in NAD+ Biosynthesis by Viewing Reaction Cycle Intermediates To Be Published

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