8BHO
 
 | | GABA-A receptor a5 homomer - a5V3 - L655708 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, ethyl (7~{S})-15-methoxy-12-oxidanylidene-2,4,11-triazatetracyclo[11.4.0.0^{2,6}.0^{7,11}]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate | | 著者 | Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Chirgadze, D.Y. | | 登録日 | 2022-10-31 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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5C4A
 | | Crystal structure of a transcribing RNA Polymerase II complex reveals a complete transcription bubble | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | 著者 | Barnes, C.O, Calero, M, Malik, I, Saphr, H, Zhang, Q, Pullara, F, Kaplan, C.D, Calero, G. | | 登録日 | 2015-06-17 | | 公開日 | 2015-08-26 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | | 主引用文献 | Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
Mol.Cell, 59, 2015
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8BG3
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3OON
 | | The structure of an outer membrance protein from Borrelia burgdorferi B31 | | 分子名称: | Outer membrane protein (Tpn50), SULFATE ION | | 著者 | Fan, Y, Bigelow, L, Feldman, B, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2010-08-31 | | 公開日 | 2010-09-22 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Insights into PG-binding, conformational change, and dimerization of the OmpA C-terminal domains from Salmonella enterica serovar Typhimurium and Borrelia burgdorferi.
Protein Sci., 26, 2017
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3ZVY
 | | PHD finger of human UHRF1 in complex with unmodified histone H3 N- terminal tail | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, E3 UBIQUITIN-PROTEIN LIGASE UHRF1, ... | | 著者 | Lallous, N, Birck, C, Mc Ewen, A.G, Legrand, P, Samama, J.P. | | 登録日 | 2011-07-28 | | 公開日 | 2011-12-07 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The Phd Finger of Human Uhrf1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers.
Plos One, 6, 2011
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8BG5
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4JSS
 | | Human carbonic anhydrase II H94D bound to a bidentate inhibitor | | 分子名称: | 1-hydroxy-2-sulfanylpyridinium, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ... | | 著者 | Martin, D.P, Hann, Z.S, Cohen, S.M. | | 登録日 | 2013-03-22 | | 公開日 | 2013-06-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site.
Inorg.Chem., 52, 2013
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6BYD
 | | Crystal structure of the second StART domain of yeast Lam4 | | 分子名称: | Membrane-anchored lipid-binding protein LAM4 | | 著者 | Jentsch, J.A, Kiburu, I.N, Wu, J, Pandey, K, Boudker, O, Menon, A.K. | | 登録日 | 2017-12-20 | | 公開日 | 2018-01-31 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.195 Å) | | 主引用文献 | Structural basis of sterol binding and transport by a yeast StARkin domain.
J. Biol. Chem., 293, 2018
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8BHG
 | | GABA-A receptor a5 heteromer - a5V2 - Bretazenil | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bretazenil, DECYL-BETA-D-MALTOPYRANOSIDE, ... | | 著者 | Miller, P.S, Malinauskas, T.M, Omari, K.E, Aricescu, A.R. | | 登録日 | 2022-10-31 | | 公開日 | 2023-11-15 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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3OTQ
 | | Soluble Epoxide Hydrolase in complex with pyrazole antagonist | | 分子名称: | Epoxide hydrolase 2, N-[4-(5-ethyl-3-pyridin-3-yl-1H-pyrazol-1-yl)phenyl]pyridine-3-carboxamide | | 著者 | Farrow, N.A. | | 登録日 | 2010-09-13 | | 公開日 | 2010-10-27 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain.
Bioorg.Med.Chem.Lett., 20, 2010
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3OTX
 | | Crystal Structure of Trypanosoma brucei rhodesiense Adenosine Kinase Complexed with Inhibitor AP5A | | 分子名称: | Adenosine kinase, putative, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, ... | | 著者 | Kuettel, S, Greenwald, J, Kostrewa, D, Ahmed, S, Scapozza, L, Perozzo, R. | | 登録日 | 2010-09-14 | | 公開日 | 2011-06-29 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation
Plos Negl Trop Dis, 5, 2011
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8BE3
 | | Crystal structure of KRasG12V-Nanobody84 | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... | | 著者 | Fischer, B, Wohlkonig, A, Steyaert, J. | | 登録日 | 2022-10-21 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Allosteric nanobodies to study the interactions between SOS1 and RAS.
Nat Commun, 15, 2024
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3ZY2
 | | Crystal structure of POFUT1 in complex with GDP (High resolution dataset) | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, PUTATIVE GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1 | | 著者 | Lira-Navarrete, E, Valero-Gonzalez, J, Villanueva, R, Martinez-Julvez, M, Tejero, T, Merino, P, Panjikar, S, Hurtado-Guerrero, R. | | 登録日 | 2011-08-17 | | 公開日 | 2011-09-14 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Structural Insights Into the Mechanism of Protein O-Fucosylation.
Plos One, 6, 2011
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3DD8
 | | Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies | | 分子名称: | 2-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamate, Carbonic anhydrase 2, MERCURY (II) ION, ... | | 著者 | Temperini, C, Innocenti, A, Scozzafava, A, Supuran, C.T. | | 登録日 | 2008-06-05 | | 公開日 | 2008-08-12 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies
Bioorg.Med.Chem.Lett., 18, 2008
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3DDS
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6N7E
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8BGI
 | | GABA-A receptor a5 homomer - a5V1 - Flumazenil | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, Pregnanolone, ... | | 著者 | Miller, P.S, Malinauskas, T.M, Omari, K.E, Aricescu, A.R. | | 登録日 | 2022-10-27 | | 公開日 | 2023-11-08 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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6C7X
 | | Carbonic anhydrase 2 in complex with 2-chloro-5'-O-sulfamoyladenosine | | 分子名称: | 2-chloro-5'-O-sulfamoyladenosine, Carbonic anhydrase 2, SODIUM ION, ... | | 著者 | Peat, T.S, Mujumdar, P, Poulsen, S.A. | | 登録日 | 2018-01-23 | | 公開日 | 2018-05-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Synthesis, structure and bioactivity of primary sulfamate-containing natural products.
Bioorg. Med. Chem. Lett., 28, 2018
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8BPD
 | | Structural and Functional Characterization of the Novel Endo-alpha(1,4)-Fucoidanase Mef1 from the Marine Bacterium Muricauda eckloniae | | 分子名称: | (2S)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, CALCIUM ION, ... | | 著者 | Mikkelsen, M.D, Meyer, A.S, Morth, J.P. | | 登録日 | 2022-11-16 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural and functional characterization of the novel endo-alpha (1,4)-fucoidanase Mef1 from the marine bacterium Muricauda eckloniae.
Acta Crystallogr D Struct Biol, 79, 2023
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4MFF
 | | Structure of human DNA polymerase beta complexed with O6MG in the template base paired with incoming non-hydrolyzable TTP | | 分子名称: | 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA polymerase beta, MAGNESIUM ION, ... | | 著者 | Koag, M.C, Min, K, Monzingo, A.F, Lee, S. | | 登録日 | 2013-08-27 | | 公開日 | 2014-04-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta.
J.Am.Chem.Soc., 136, 2014
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8BG4
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8BIY
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6C3O
 | | Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | | 著者 | Lee, K.P.K, Chen, J, MacKinnon, R. | | 登録日 | 2018-01-10 | | 公開日 | 2018-01-31 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Molecular structure of human KATP in complex with ATP and ADP
Elife, 6, 2017
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8BQ1
 | | Herpes simplex virus type 1 protease | | 分子名称: | Assemblin, GLYCEROL | | 著者 | Pachota, M, Grzywa, R, Plewka, J, Wilk, P, Mackereth, C, Czarna, A, Sienczyk, M, Pyrc, K. | | 登録日 | 2022-11-18 | | 公開日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Herpes simplex virus type 1 protease
To Be Published
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8BJ0
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