3OTX

Crystal Structure of Trypanosoma brucei rhodesiense Adenosine Kinase Complexed with Inhibitor AP5A

Summary for 3OTX

Entry DOI	10.2210/pdb3otx/pdb
Related	2XTB
Descriptor	Adenosine kinase, putative, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, SODIUM ION, ... (4 entities in total)
Functional Keywords	adenosine kinase, ap5a, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Trypanosoma brucei
Total number of polymer chains	2
Total formula weight	78141.67
Authors	Kuettel, S.,Greenwald, J.,Kostrewa, D.,Ahmed, S.,Scapozza, L.,Perozzo, R. (deposition date: 2010-09-14, release date: 2011-06-29, Last modification date: 2024-10-30)
Primary citation	Kuettel, S.,Greenwald, J.,Kostrewa, D.,Ahmed, S.,Scapozza, L.,Perozzo, R. Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation Plos Negl Trop Dis, 5:e1164-e1164, 2011 Cited by PubMed Abstract: The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis. Unlike mammalian cells, trypanosomes lack de novo purine synthesis and completely rely on salvage from their hosts. One of the key enzymes is adenosine kinase which catalyzes the phosphorylation of ingested adenosine to form adenosine monophosphate (AMP) utilizing adenosine triphosphate (ATP) as the preferred phosphoryl donor. PubMed: 21629723 DOI: 10.1371/journal.pntd.0001164 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation