PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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5ZAM	Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate 分子名称: Endoribonuclease Dicer, RISC-loading complex subunit TARBP2, RNA (73-mer) 著者 Liu, Z, Wang, J, Cheng, H, Ke, X, Sun, L, Zhang, Q.C, Wang, H.-W. 登録日 2018-02-07 公開日 2018-05-09 最終更新日 2020-08-05 実験手法 ELECTRON MICROSCOPY (5.7 Å) 主引用文献 Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell, 173, 2018
1Q79	CRYSTAL STRUCTURE OF MAMMALIAN POLY(A) POLYMERASE 分子名称: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ... 著者 Martin, G, Moglich, A, Keller, W, Doublie, S. 登録日 2003-08-16 公開日 2004-09-07 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase. J.Mol.Biol., 341, 2004
7MLI	Crystal structure of Thermus thermophilus reiterative transcription complex with 5nt oligo-C RNA 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*CP*TP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*AP*GP*GP*GP*CP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Liu, Y, Ebright, R.H. 登録日 2021-04-28 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7MLB	Crystal structure of Thermus thermophilus transcription initiation complex with 5nt RNA 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*AP*GP*GP*GP*AP*TP*GP*CP*AP*G)-3'), DNA (5'-D(P*CP*TP*GP*CP*AP*TP*CP*CP*CP*TP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Liu, Y, Ebright, R.H. 登録日 2021-04-28 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7MLJ	Crystal structure of Thermus thermophilus reiterative transcription complex with 4nt oligo-G RNA 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*GP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*GP*CP*CP*CP*TP*GP*AP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Liu, Y, Ebright, R.H. 登録日 2021-04-28 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.75 Å) 主引用文献 Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
2Q66	Structure of Yeast Poly(A) Polymerase with ATP and oligo(A) 分子名称: 1,2-ETHANEDIOL, 5'-R(P*AP*AP*AP*AP*A)-3', ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Bohm, A, Balbo, P. 登録日 2007-06-04 公開日 2007-08-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Mechanism of poly(A) polymerase: structure of the enzyme-MgATP-RNA ternary complex and kinetic analysis. Structure, 15, 2007
5ZAL	Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate 分子名称: Endoribonuclease Dicer, RISC-loading complex subunit TARBP2, RNA (73-mer) 著者 Liu, Z, Wang, J, Cheng, H, Ke, X, Sun, L, Zhang, Q.C, Wang, H.-W. 登録日 2018-02-07 公開日 2018-05-09 最終更新日 2020-08-05 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell, 173, 2018
3TBI	Crystal structure of T4 gp33 bound to E. coli RNAP beta-flap domain 分子名称: DNA-directed RNA polymerase subunit beta, RNA polymerase-associated protein Gp33 著者 Twist, K.A.F, Campbell, E.A, Darst, S.A. 登録日 2011-08-06 公開日 2011-11-23 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of T4 gp33 bound to E. coli RNAP beta-flap domain To be Published
3NL0	Mutant P44S M296I of Foot-and-mouth disease Virus RNA-dependent RNA polymerase 分子名称: 3D polymerase, 5'-R(*G*GP*GP*CP*CP*C)-3', 5'-R(P*UP*GP*GP*GP*CP*CP*C)-3', ... 著者 Agudo, R, Ferrer-Orta, C, Arias, A, Perez-Luque, R, Verdaguer, N, Domingo, E. 登録日 2010-06-21 公開日 2011-07-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape. Plos Pathog., 6, 2010
1Q78	Crystal structure of poly(A) polymerase in complex with 3'-dATP and magnesium chloride 分子名称: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Poly(A) polymerase alpha 著者 Martin, G, Moglich, A, Keller, W, Doublie, S. 登録日 2003-08-16 公開日 2004-09-07 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase. J.Mol.Biol., 341, 2004
6GO3	TdT chimera (Loop1 of pol mu) - apoenzyme 分子名称: DNA nucleotidylexotransferase,DNA-directed DNA/RNA polymerase mu,DNA nucleotidylexotransferase 著者 Loc'h, J, Gerodimos, C.A, Rosario, S, Lieber, M.R, Delarue, M. 登録日 2018-06-01 公開日 2019-06-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural evidence for an intransbase selection mechanism involving Loop1 in polymerase mu at an NHEJ double-strand break junction. J.Biol.Chem., 294, 2019
6GO4	TdT chimera (Loop1 of pol mu) - binary complex with ddCTP 分子名称: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA nucleotidylexotransferase,DNA-directed DNA/RNA polymerase mu,DNA nucleotidylexotransferase, MAGNESIUM ION, ... 著者 Loc'h, J, Gerodimos, C.A, Rosario, S, Lieber, M.R, Delarue, M. 登録日 2018-06-01 公開日 2019-06-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Structural evidence for an intransbase selection mechanism involving Loop1 in polymerase mu at an NHEJ double-strand break junction. J.Biol.Chem., 294, 2019
6GO7	TdT chimera (Loop1 of pol mu) - full DNA synapsis complex 分子名称: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*AP*AP*AP*C)-3'), DNA (5'-D(*TP*TP*TP*TP*TP*GP*C)-3'), ... 著者 Loc'h, J, Gerodimos, C.A, Rosario, S, Lieber, M.R, Delarue, M. 登録日 2018-06-01 公開日 2019-06-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural evidence for an intransbase selection mechanism involving Loop1 in polymerase mu at an NHEJ double-strand break junction. J.Biol.Chem., 294, 2019
3J7P	Structure of the 80S mammalian ribosome bound to eEF2 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... 著者 Voorhees, R.M, Fernandez, I.S, Scheres, S.H.W, Hegde, R.S. 登録日 2014-08-01 公開日 2014-09-03 最終更新日 2018-07-18 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution. Cell(Cambridge,Mass.), 157, 2014
5JS2	Human Argonaute-2 Bound to a Modified siRNA 分子名称: MAGNESIUM ION, PHENOL, PHOSPHATE ION, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2016-05-07 公開日 2016-07-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.954 Å) 主引用文献 Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide. J.Am.Chem.Soc., 138, 2016
5U0C	Structure of Zika virus NS5 RNA polymerase domain 分子名称: NS5 RNA polymerase domain, ZINC ION 著者 Zhao, B, Du, F. 登録日 2016-11-23 公開日 2017-03-29 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure and function of the Zika virus full-length NS5 protein. Nat Commun, 8, 2017
5ZC9	Crystal structure of the human eIF4A1-ATP analog-RocA-polypurine RNA complex 分子名称: (1R,2R,3S,3aR,8bS)-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-1,8b-bis(oxidanyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide, Eukaryotic initiation factor 4A-I, MAGNESIUM ION, ... 著者 Iwasaki, W, Takahashi, M, Sakamoto, A, Iwasaki, S, Ito, T. 登録日 2018-02-16 公開日 2019-01-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA. Mol. Cell, 73, 2019
4ZQQ	Apo form of influenza strain H1N1 polymerase acidic subunit N-terminal region 分子名称: MANGANESE (II) ION, Polymerase acidic protein,Polymerase acidic protein, SULFATE ION 著者 Fudo, S, Yamamoto, N, Nukaga, M, Odagiri, T, Tashiro, M, Neya, S, Hoshino, T. 登録日 2015-05-11 公開日 2015-06-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit. Biochemistry, 55, 2016
1XHX	Phi29 DNA Polymerase, orthorhombic crystal form 分子名称: DNA polymerase, MAGNESIUM ION, SULFATE ION 著者 Kamtekar, S, Berman, A.J, Wang, J, Lazaro, J.M, de Vega, M, Blanco, L, Salas, M, Steitz, T.A. 登録日 2004-09-21 公開日 2004-12-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Insights into Strand Displacement and Processivity from the Crystal Structure of the Protein-Primed DNA Polymerase of Bacteriophage phi29 Mol.Cell, 16, 2004
1XHZ	Phi29 DNA polymerase, orthorhombic crystal form, ssDNA complex 分子名称: 5'-D(*TP*TP*TP*TP*T)-3', DNA polymerase 著者 Kamtekar, S, Berman, A.J, Wang, J, Lazaro, J.M, de Vega, M, Blanco, L, Salas, M, Steitz, T.A. 登録日 2004-09-21 公開日 2004-12-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Insights into Strand Displacement and Processivity from the Crystal Structure of the Protein-Primed DNA Polymerase of Bacteriophage phi29 Mol.Cell, 16, 2004
4ZHZ	Endonuclease inhibitor bound to influenza strain H1N1 polymerase acidic subunit N-terminal region with expelling one of the metal ions in the active site 分子名称: 5-(2-chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde, MANGANESE (II) ION, Polymerase acidic protein, ... 著者 Fudo, S, Yamamoto, N, Nukaga, M, Odagiri, T, Tashiro, M, Neya, S, Hoshino, T. 登録日 2015-04-27 公開日 2015-05-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit Biochemistry, 55, 2016
4YYL	Phenolic acid derivative bound to influenza strain H1N1 polymerase subunit PA endonuclease 分子名称: 2-(4-fluorophenoxy)-1-(2,3,4-trihydroxyphenyl)ethanone, MANGANESE (II) ION, Polymerase acidic protein, ... 著者 Fudo, S, Yamamoto, N, Nukaga, M, Odagiri, T, Tashiro, M, Neya, S, Hoshino, T. 登録日 2015-03-24 公開日 2015-04-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.905 Å) 主引用文献 Structural and computational study on inhibitory compounds for endonuclease activity of influenza virus polymerase Bioorg.Med.Chem., 23, 2015
4ZI0	Endonuclease inhibitor bound to influenza strain H1N1 polymerase acidic subunit N-terminal region without a chelation to the metal ions in the active site 分子名称: 4-{(E)-[2-(4-chlorophenyl)hydrazinylidene]methyl}benzene-1,2,3-triol, MANGANESE (II) ION, Polymerase acidic protein, ... 著者 Fudo, S, Yamamoto, N, Nukaga, M, Odagiri, T, Tashiro, M, Neya, S, Hoshino, T. 登録日 2015-04-27 公開日 2015-05-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.802 Å) 主引用文献 Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit Biochemistry, 55, 2016
7XUR	The cryo-EM structure of human mini-SNAPc in complex with hU6-1 PSE 分子名称: DNA (35-MER), ZINC ION, snRNA-activating protein complex subunit 1, ... 著者 Wang, W, Sun, J.F. 登録日 2022-05-19 公開日 2022-12-07 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (3.49 Å) 主引用文献 Structural basis of human SNAPc recognizing proximal sequence element of snRNA promoter. Nat Commun, 13, 2022
4OAV	Complete human RNase L in complex with 2-5A (5'-ppp heptamer), AMPPCP and RNA substrate. 分子名称: (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-({[(S)-hydroxy{[(2R,3S,4S)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]oxy}phosphoryl]oxy}methyl)tetrahydrofuran-3-yl dihydrogen phosphate, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... 著者 Han, Y, Donovan, J, Rath, S, Whitney, G, Chitrakar, A, Korennykh, A. 登録日 2014-01-06 公開日 2014-03-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. Science, 343, 2014

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