8S93
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![BU of 8s93 by Molmil](/molmil-images/mine/8s93) | Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase | 分子名称: | 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, GLYCEROL, Tyrosine-protein kinase BTK, ... | 著者 | Lin, D.Y, Andreotti, A.H. | 登録日 | 2023-03-27 | 公開日 | 2023-08-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
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8SSN
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![BU of 8ssn by Molmil](/molmil-images/mine/8ssn) | Abl kinase in complex with SKI and asciminib | 分子名称: | 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Ludewig, H, Kim, C, Kern, D. | 登録日 | 2023-05-08 | 公開日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | A biophysical framework for double-drugging kinases. Proc.Natl.Acad.Sci.USA, 120, 2023
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8VJC
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![BU of 8vjc by Molmil](/molmil-images/mine/8vjc) | Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound, asymmetric conformation. | 分子名称: | Insulin-like growth factor II, Isoform Short of Insulin receptor | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | 登録日 | 2024-01-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8VJB
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![BU of 8vjb by Molmil](/molmil-images/mine/8vjb) | Cryo-EM structure of short form insulin receptor (IR-A) with four IGF2 bound, symmetric conformation. | 分子名称: | Insulin-like growth factor II, Isoform Short of Insulin receptor | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | 登録日 | 2024-01-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8U4E
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![BU of 8u4e by Molmil](/molmil-images/mine/8u4e) | Cryo-EM structure of long form insulin receptor (IR-B) with three IGF2 bound, asymmetric conformation. | 分子名称: | Insulin receptor, Insulin-like growth factor II | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | 登録日 | 2023-09-10 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8U4B
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![BU of 8u4b by Molmil](/molmil-images/mine/8u4b) | Cryo-EM structure of long form insulin receptor (IR-B) in the apo state | 分子名称: | Insulin receptor | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | 登録日 | 2023-09-10 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8U4C
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![BU of 8u4c by Molmil](/molmil-images/mine/8u4c) | Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation. | 分子名称: | Insulin receptor, Insulin-like growth factor II | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | 登録日 | 2023-09-10 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8XN8
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![BU of 8xn8 by Molmil](/molmil-images/mine/8xn8) | The Crystal Structure of SRC from Biortus. | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. | 登録日 | 2023-12-29 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The Crystal Structure of SRC from Biortus. To Be Published
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9AXH
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![BU of 9axh by Molmil](/molmil-images/mine/9axh) | Crystal structure of KSR1/MEK1 complex heterotetramer with NST-628 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9AXY
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![BU of 9axy by Molmil](/molmil-images/mine/9axy) | Crystal structure of BRAF/MEK complex with NST-628 and inactive RAF | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9AXM
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![BU of 9axm by Molmil](/molmil-images/mine/9axm) | Crystal structure of ARAF/MEK1 complex with NST-628 and a RAF dimer | 分子名称: | 1,2-ETHANEDIOL, Dual specificity mitogen-activated protein kinase kinase 1, GLYCEROL, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9AXX
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![BU of 9axx by Molmil](/molmil-images/mine/9axx) | Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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2PTK
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![BU of 2ptk by Molmil](/molmil-images/mine/2ptk) | CHICKEN SRC TYROSINE KINASE | 分子名称: | TYROSINE-PROTEIN KINASE TRANSFORMING PROTEIN SRC | 著者 | Williams, J.C, Wierenga, R. | 登録日 | 1997-06-17 | 公開日 | 1997-12-24 | 最終更新日 | 2018-04-11 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions J.Mol.Biol., 274, 1997
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2OZO
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![BU of 2ozo by Molmil](/molmil-images/mine/2ozo) | Autoinhibited intact human ZAP-70 | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase ZAP-70 | 著者 | Deindl, S, Kadlecek, T.A, Brdicka, T, Cao, X, Weiss, A, Kuriyan, J. | 登録日 | 2007-02-26 | 公開日 | 2007-05-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70. Cell(Cambridge,Mass.), 129, 2007
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2QOB
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![BU of 2qob by Molmil](/molmil-images/mine/2qob) | Human EphA3 kinase domain, base structure | 分子名称: | BETA-MERCAPTOETHANOL, Ephrin receptor | 著者 | Davis, T, Walker, J.R, Newman, E.M, Mackenzie, F, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2007-07-20 | 公開日 | 2007-08-21 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3). Structure, 16, 2008
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2QOO
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![BU of 2qoo by Molmil](/molmil-images/mine/2qoo) | Human EphA3 kinase and juxtamembrane region, Y596F:Y602F:Y742F triple mutant | 分子名称: | Ephrin receptor | 著者 | Davis, T, Walker, J.R, Newman, E.M, Mackenzie, F, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2007-07-20 | 公開日 | 2007-08-28 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3). Structure, 16, 2008
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2QOF
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![BU of 2qof by Molmil](/molmil-images/mine/2qof) | Human EphA3 kinase and juxtamembrane region, Y596F mutant | 分子名称: | BETA-MERCAPTOETHANOL, Ephrin receptor | 著者 | Davis, T, Walker, J.R, Newman, E.M, Mackenzie, F, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2007-07-20 | 公開日 | 2007-08-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3). Structure, 16, 2008
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2QO2
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![BU of 2qo2 by Molmil](/molmil-images/mine/2qo2) | Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure | 分子名称: | BETA-MERCAPTOETHANOL, Ephrin receptor | 著者 | Davis, T, Walker, J.R, Newman, E.M, Mackenzie, F, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2007-07-19 | 公開日 | 2007-08-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3). Structure, 16, 2008
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2QON
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![BU of 2qon by Molmil](/molmil-images/mine/2qon) | Human EphA3 kinase and juxtamembrane region, Y596F:Y602F:Y742A triple mutant | 分子名称: | Ephrin receptor, GLYCEROL | 著者 | Davis, T, Walker, J.R, Newman, E.M, Mackenzie, F, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2007-07-20 | 公開日 | 2007-08-28 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3). Structure, 16, 2008
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2QOD
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![BU of 2qod by Molmil](/molmil-images/mine/2qod) | Human EphA3 kinase and juxtamembrane region, Y602F mutant | 分子名称: | Ephrin receptor | 著者 | Davis, T, Walker, J.R, Newman, E.M, Mackenzie, F, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2007-07-20 | 公開日 | 2007-08-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3). Structure, 16, 2008
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2QO9
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![BU of 2qo9 by Molmil](/molmil-images/mine/2qo9) | Human EphA3 kinase and juxtamembrane region, phosphorylated, AMP-PNP bound | 分子名称: | Ephrin receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Davis, T, Walker, J.R, Newman, E.M, Mackenzie, F, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2007-07-20 | 公開日 | 2007-08-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3). Structure, 16, 2008
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8BW9
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![BU of 8bw9 by Molmil](/molmil-images/mine/8bw9) | |
3MDY
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![BU of 3mdy by Molmil](/molmil-images/mine/3mdy) | Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189 | 分子名称: | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, Bone morphogenetic protein receptor type-1B, Peptidyl-prolyl cis-trans isomerase FKBP1A | 著者 | Chaikuad, A, Sanvitale, C, Mahajan, P, Daga, N, Cooper, C, Krojer, T, Alfano, I, Knapp, S, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) | 登録日 | 2010-03-31 | 公開日 | 2010-05-19 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189 To be Published
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8DFM
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![BU of 8dfm by Molmil](/molmil-images/mine/8dfm) | Ectodomain of full-length wild-type KIT-SCF dimers | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ... | 著者 | Krimmer, S.G, Bertoletti, N, Mi, W, Schlessinger, J. | 登録日 | 2022-06-22 | 公開日 | 2023-03-29 | 最終更新日 | 2023-04-05 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proc.Natl.Acad.Sci.USA, 120, 2023
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8DFQ
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![BU of 8dfq by Molmil](/molmil-images/mine/8dfq) | Ectodomain of full-length KIT(T417I,delta418-419)-SCF dimers | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ... | 著者 | Krimmer, S.G, Bertoletti, N, Mi, W, Schlessinger, J. | 登録日 | 2022-06-22 | 公開日 | 2023-03-29 | 最終更新日 | 2023-04-05 | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | 主引用文献 | Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proc.Natl.Acad.Sci.USA, 120, 2023
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