3F99
| W354F Yersinia enterocolitica PTPase apo form | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase yopH | 著者 | Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C. | 登録日 | 2008-11-13 | 公開日 | 2009-01-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J.Am.Chem.Soc., 131, 2009
|
|
3F9B
| W354F Yersinia enterocolitica PTPase complexed with divanadate | 分子名称: | Divanadate ion, GLYCEROL, Tyrosine-protein phosphatase yopH, ... | 著者 | Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C. | 登録日 | 2008-11-13 | 公開日 | 2009-01-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J.Am.Chem.Soc., 131, 2009
|
|
3F9A
| W354F Yersinia enterocolitica PTPase complexed with tungstate | 分子名称: | TUNGSTATE(VI)ION, Tyrosine-protein phosphatase yopH | 著者 | Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C. | 登録日 | 2008-11-13 | 公開日 | 2009-01-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J.Am.Chem.Soc., 131, 2009
|
|
3H2X
| |
3I36
| |
3I7Z
| Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, EGFR receptor fragment, GLYCEROL, ... | 著者 | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | 登録日 | 2009-07-09 | 公開日 | 2010-03-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285, 2010
|
|
3I80
| Protein Tyrosine Phosphatase 1B - Transition state analog for the second catalytic step | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... | 著者 | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | 登録日 | 2009-07-09 | 公開日 | 2010-03-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285, 2010
|
|
3A5J
| |
3A5K
| |
3M4U
| |
3MOW
| Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1 | 分子名称: | (2Z)-2-[(1R)-3-{[(1R,2S,3R,6S,7S,10S,12S,15E,17E)-18-carboxy-16-ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5-oxooctade ca-15,17-dien-1-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Zhang, Z.-Y, Liu, S, Yu, Z, Yu, X. | 登録日 | 2010-04-23 | 公開日 | 2011-05-04 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1 To be Published
|
|
3O4S
| |
3O4T
| |
3O4U
| |
3O5X
| Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor | 分子名称: | 3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Zhang, Z.-Y, Zhang, X, He, Y, Liu, S, Yu, Z, Jiang, Z, Yang, Z, Dong, Y, Nabinger, S.C, Wu, L, Gunawan, A.M, Wang, L, Chan, R.J. | 登録日 | 2010-07-28 | 公開日 | 2010-08-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). J.Med.Chem., 53, 2010
|
|
3OLR
| |
3OMH
| Crystal structure of PTPN22 in complex with SKAP-HOM pTyr75 peptide | 分子名称: | Src kinase-associated phosphoprotein 2, Tyrosine-protein phosphatase non-receptor type 22 | 著者 | Yu, X, Sun, J.-P, Zhang, S, Zhang, Z.-Y. | 登録日 | 2010-08-26 | 公開日 | 2011-06-29 | 最終更新日 | 2011-09-14 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Substrate Specificity of Lymphoid-specific Tyrosine Phosphatase (Lyp) and Identification of Src Kinase-associated Protein of 55 kDa Homolog (SKAP-HOM) as a Lyp Substrate. J.Biol.Chem., 286, 2011
|
|
3PS5
| Crystal structure of the full-length Human Protein Tyrosine Phosphatase SHP-1 | 分子名称: | SULFATE ION, Tyrosine-protein phosphatase non-receptor type 6 | 著者 | Wang, W, Liu, L, Song, X, Mo, Y, Komma, C, Bellamy, H.D, Zhao, Z.J, Zhou, G.W. | 登録日 | 2010-11-30 | 公開日 | 2011-04-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation. J.Cell.Biochem., 112, 2011
|
|
2Y2F
| Crystal structure of Yersinia pestis YopH in complex with an aminooxy- containing platform compound for inhibitor design | 分子名称: | PROTEIN-TYROSINE PHOSPHATASE YOPH, [4-[3-(DIFLUORO-PHOSPHONO-METHYL)PHENYL]PHENYL]METHOXYAZANIUM | 著者 | Lountos, G.T, Bahta, M, Dyas, B, Ulrich, R.G, Waugh, D.S, Burke, T.R. | 登録日 | 2010-12-14 | 公開日 | 2011-03-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Utilization of Nitrophenylphosphates and Oxime-Based Ligation for the Development of Nanomolar Affinity Inhibitors of the Yersinia Pestis Outer Protein H (Yoph) Phosphatase. J.Med.Chem., 54, 2011
|
|
3QCF
| |
3QCC
| |
3QCG
| |
3QCH
| |
3QCE
| |
3QCL
| |