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3TDJ
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Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-97 at 1.95 A resolution
分子名称: 4-ethyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, CHLORIDE ION, GLUTAMIC ACID, ...
著者Krintel, C, Frydenvang, K, Gajhede, M, Kastrup, J.S.
登録日2011-08-11
公開日2011-09-21
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2.
Biochem.J., 441, 2012
3TKD
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Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and cyclothiazide at 1.45 A resolution
分子名称: CYCLOTHIAZIDE, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ...
著者Krintel, C, Frydenvang, K, Gajhede, M, Kastrup, J.S.
登録日2011-08-26
公開日2011-09-21
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2.
Biochem.J., 441, 2012
3TZA
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Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 1.9A resolution
分子名称: (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid, Glutamate receptor 2,Glutamate receptor 2, SULFATE ION
著者Frydenvang, K, Kastrup, J.S.
登録日2011-09-27
公開日2011-10-26
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure
J.Med.Chem., 54, 2011
3U92
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Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, Glutamate receptor, ...
著者Kumar, J, Mayer, M.L.
登録日2011-10-17
公開日2012-09-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface.
Neuron, 76, 2012
3U94
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Crystal structure of the GluK3 ligand binding domain complex with glutamate and zinc: P21212 form
分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ...
著者Kumar, J, Mayer, M.L.
登録日2011-10-17
公開日2012-09-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.962 Å)
主引用文献Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface.
Neuron, 76, 2012
3U93
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Crystal structure of the GluK3 ligand binding domain complex with glutamate and zinc: P2221 form
分子名称: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ...
著者Kumar, J, Mayer, M.L.
登録日2011-10-17
公開日2012-09-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.881 Å)
主引用文献Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface.
Neuron, 76, 2012
3UA8
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Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2
分子名称: Glutamate receptor 2, N-methyl-1-{3-[(methylsulfonyl)amino]-2,4-dioxo-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-6-yl}-1H-imidazole-4-carboxamide
著者Kallen, J.
登録日2011-10-21
公開日2012-01-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists.
Bioorg.Med.Chem.Lett., 22, 2012
4DLD
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Crystal structure of the GluK1 ligand-binding domain (S1S2) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 2.0 A resolution
分子名称: (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid, CHLORIDE ION, GLYCEROL, ...
著者Venskutonyte, R, Frydenvang, K, Kastrup, J.S.
登録日2012-02-06
公開日2012-10-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors
Chemmedchem, 7, 2012
4E0W
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Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with kainate
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, Glutamate receptor, ...
著者Venskutonyte, R, Frydenvang, K, Kastrup, J.S.
登録日2012-03-05
公開日2012-05-02
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.3501 Å)
主引用文献Kainate induces various domain closures in AMPA and kainate receptors.
Neurochem Int, 61, 2012
4E0X
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Crystal structure of the kainate receptor GluK1 ligand-binding domain in complex with kainate in the absence of glycerol
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, Glutamate receptor, ...
著者Frydenvang, K, Kastrup, J.S.
登録日2012-03-05
公開日2012-04-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Kainate induces various domain closures in AMPA and kainate receptors.
Neurochem Int, 61, 2012
4F29
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Quisqualate bound to the ligand binding domain of GluA3i
分子名称: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2012-05-07
公開日2012-05-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.749 Å)
主引用文献The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
Biochemistry, 51, 2012
4F1Y
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CNQX bound to the ligand binding domain of GluA3
分子名称: 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 3, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2012-05-07
公開日2012-05-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
Biochemistry, 51, 2012
4F22
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Kainate bound to the K660A mutant of the ligand binding domain of GluA3
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 3, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2012-05-07
公開日2012-05-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
Biochemistry, 51, 2012
4F2Q
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Quisqualate bound to the D655A mutant of the ligand binding domain of GluA3
分子名称: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2012-05-08
公開日2012-05-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.202 Å)
主引用文献The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
Biochemistry, 51, 2012
4F31
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Kainate bound to the D655A mutant of the ligand binding domain of GluA3
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 3, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2012-05-08
公開日2012-05-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.286 Å)
主引用文献The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
Biochemistry, 51, 2012
4F2O
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Quisqualate bound to the D655A mutant of the ligand binding domain of GluA3
分子名称: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2012-05-08
公開日2012-05-23
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.912 Å)
主引用文献The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
Biochemistry, 51, 2012
4F3B
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Glutamate bound to the D655A mutant of the ligand binding domain of GluA3
分子名称: GLUTAMIC ACID, Glutamate receptor 3, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2012-05-09
公開日2012-05-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.818 Å)
主引用文献The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
Biochemistry, 51, 2012
4F39
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Kainate bound to the ligand binding domain of GluA3
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 3, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2012-05-09
公開日2012-05-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.834 Å)
主引用文献The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
Biochemistry, 51, 2012
4F3G
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Kainate bound to the ligand binding domain of GluA3i
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 3, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2012-05-09
公開日2012-05-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.064 Å)
主引用文献The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
Biochemistry, 51, 2012
4FAT
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Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator
分子名称: 2-({[4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, GLUTAMIC ACID, GLYCEROL, ...
著者Maclean, J.K.F, Kazemier, B.
登録日2012-05-22
公開日2012-07-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy.
Neuropharmacology, 64, 2013
4G8N
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Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist G8M
分子名称: (1S,2R)-2-[(S)-amino(carboxy)methyl]cyclobutanecarboxylic acid, CHLORIDE ION, Glutamate receptor, ...
著者Venskutonyte, R, Kastrup, J.S, Frydenvang, K, Gajhede, M.
登録日2012-07-23
公開日2012-08-29
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors.
J.Struct.Biol., 180, 2012
4G8M
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Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist CBG-IV at 2.05A resolution
分子名称: (1S,2R)-2-[(S)-amino(carboxy)methyl]cyclobutanecarboxylic acid, CHLORIDE ION, GLYCEROL, ...
著者Juknaite, L, Frydenvang, K, Kastrup, J.S, Gajhede, M.
登録日2012-07-23
公開日2012-08-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors.
J.Struct.Biol., 180, 2012
4GXS
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Ligand binding domain of GluA2 (AMPA/glutamate receptor) bound to (-)-kaitocephalin
分子名称: (5R)-2-[(1S,2R)-2-amino-2-carboxy-1-hydroxyethyl]-5-{(2S)-2-carboxy-2-[(3,5-dichloro-4-hydroxybenzoyl)amino]ethyl}-L-proline, Glutamate receptor 2, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2012-09-04
公開日2012-10-17
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9634 Å)
主引用文献The structure of (-)-kaitocephalin bound to the ligand binding domain of the (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/glutamate receptor, GluA2.
J.Biol.Chem., 287, 2012
4H8J
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Structure of GluA2-LBD in complex with MES
分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Glutamate receptor 2, ...
著者Reiter, A, Skerra, A, Trauner, D, Schiefner, A.
登録日2012-09-22
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis of an artificial photoreceptor
To be Published
4H8I
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Structure of GluK2-LBD in complex with GluAzo
分子名称: (4R)-4-[(2E)-3-{4-[(E)-phenyldiazenyl]phenyl}prop-2-en-1-yl]-L-glutamic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ...
著者Reiter, A, Skerra, A, Trauner, D, Schiefner, A.
登録日2012-09-22
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A photoswitchable neurotransmitter analogue bound to its receptor.
Biochemistry, 52, 2013

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件を2024-06-12に公開中

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