4G8N

Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist G8M

Summary for 4G8N

• Entry DOI: 10.2210/pdb4g8n/pdb
• Related: 3S9E
• Descriptor: Glutamate receptor, ionotropic kainate 3, (1S,2R)-2-[(S)-amino(carboxy)methyl]cyclobutanecarboxylic acid, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: membrane protein, ionotropic glutamate receptor, ligand binding domain, agonist complex, membrane protein-agonist complex, membrane protein/agonist
• Biological source: Rattus norvegicus (rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P42264
• Total number of polymer chains: 1
• Total formula weight: 29414.72

Authors

Venskutonyte, R.,Kastrup, J.S.,Frydenvang, K.,Gajhede, M. (deposition date: 2012-07-23, release date: 2012-08-29, Last modification date: 2023-09-13)

• Primary citation: Juknaite, L.,Venskutonyte, R.,Assaf, Z.,Faure, S.,Gefflaut, T.,Aitken, D.J.,Nielsen, B.,Gajhede, M.,Kastrup, J.S.,Bunch, L.,Frydenvang, K.,Pickering, D.S.; Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors.; J.Struct.Biol., 180:39-46, 2012; PubMed: 22789682; DOI: 10.1016/j.jsb.2012.07.001

Experimental method

X-RAY DIFFRACTION (2.3 Å)