2IGB
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![BU of 2igb by Molmil](/molmil-images/mine/2igb) | Crystal Structure of PyrR, The Regulator Of The Pyrimidine Biosynthetic Operon In Bacillus caldolyticus, UMP-bound form | 分子名称: | 1,2-ETHANEDIOL, PyrR bifunctional protein, URIDINE-5'-MONOPHOSPHATE | 著者 | Chander, P, Switzer, R.L, Smith, J.L. | 登録日 | 2006-09-22 | 公開日 | 2007-09-25 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | PyrR, the regulator of the pyrimidine biosynthetic operon in Bacillus caldolyticus To be Published
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3S7A
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![BU of 3s7a by Molmil](/molmil-images/mine/3s7a) | Human dihydrofolate reductase binary complex with PT684 | 分子名称: | 4-({5-[(2,4-diaminopteridin-6-yl)methyl]-5H-dibenzo[b,f]azepin-2-yl}oxy)butanoic acid, Dihydrofolate reductase, SULFATE ION | 著者 | Cody, V, Pace, J, Nowak, J. | 登録日 | 2011-05-26 | 公開日 | 2011-10-05 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode. Acta Crystallogr.,Sect.D, 67, 2011
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8G57
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![BU of 8g57 by Molmil](/molmil-images/mine/8g57) | Structure of nucleosome-bound Sirtuin 6 deacetylase | 分子名称: | DNA strand 1, DNA strand 2, Histone H2A type 1-B/E, ... | 著者 | Chio, U.S, Rechiche, O, Bryll, A.R, Zhu, J, Feldman, J.L, Peterson, C.L, Tan, S, Armache, J.-P. | 登録日 | 2023-02-11 | 公開日 | 2023-04-26 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Cryo-EM structure of the human Sirtuin 6-nucleosome complex. Sci Adv, 9, 2023
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2JEX
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![BU of 2jex by Molmil](/molmil-images/mine/2jex) | Transcription activator structure reveals redox control of a replication initiation reaction | 分子名称: | REGULATORY PROTEIN E2 | 著者 | Sanders, C.M, Sizov, D, Seavers, P.R, Ortiz-Lombardia, M, Antson, A.A. | 登録日 | 2007-01-24 | 公開日 | 2007-05-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Transcription Activator Structure Reveals Redox Control of a Replication Initiation Reaction. Nucleic Acids Res., 35, 2007
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1X75
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![BU of 1x75 by Molmil](/molmil-images/mine/1x75) | CcdB:GyrA14 complex | 分子名称: | Cytotoxic protein ccdB, DNA gyrase subunit A | 著者 | Dao-Thi, M.H, Van Melderen, L, De Genst, E, Wyns, L, Loris, R. | 登録日 | 2004-08-13 | 公開日 | 2005-05-17 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Molecular Basis of Gyrase Poisoning by the Addiction Toxin CcdB J.Mol.Biol., 348, 2005
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2JEU
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![BU of 2jeu by Molmil](/molmil-images/mine/2jeu) | Transcription activator structure reveals redox control of a replication initiation reaction | 分子名称: | REGULATORY PROTEIN E2 | 著者 | Sanders, C.M, Sizov, D, Seavers, P.R, Ortiz-Lombardia, M, Antson, A.A. | 登録日 | 2007-01-23 | 公開日 | 2007-05-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Transcription Activator Structure Reveals Redox Control of a Replication Initiation Reaction. Nucleic Acids Res., 35, 2007
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1H6F
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![BU of 1h6f by Molmil](/molmil-images/mine/1h6f) | Human TBX3, a transcription factor responsible for ulnar-mammary syndrome, bound to a palindromic DNA site | 分子名称: | 5'-D(*TP*AP*AP*TP*TP*TP*CP*AP*CP*AP*CP*CP*TP* AP*GP*GP*TP*GP*TP*GP*AP*AP*AP*T)-3', MAGNESIUM ION, T-BOX TRANSCRIPTION FACTOR TBX3 | 著者 | Coll, M, Muller, C.W. | 登録日 | 2001-06-13 | 公開日 | 2002-04-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of the DNA-Bound T-Box Domain of Human Tbx3, a Transcription Factor Responsible for Ulnar- Mammary Syndrome Structure, 10, 2002
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1W22
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![BU of 1w22 by Molmil](/molmil-images/mine/1w22) | Crystal structure of inhibited human HDAC8 | 分子名称: | HISTONE DEACETYLASE 8, N-HYDROXY-4-(METHYL{[5-(2-PYRIDINYL)-2-THIENYL]SULFONYL}AMINO)BENZAMIDE, POTASSIUM ION, ... | 著者 | Vannini, A, Volpari, C, Caroli Casavola, E, Di Marco, S. | 登録日 | 2004-06-25 | 公開日 | 2004-09-24 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of a Eukaryotic Zn-Dependent Histone Deacetylase,Human Hdac8,Complexed with a Hydroxamic Acid Inhibitor Proc.Natl.Acad.Sci.USA, 101, 2004
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1VUB
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![BU of 1vub by Molmil](/molmil-images/mine/1vub) | CCDB, A TOPOISOMERASE POISON FROM E. COLI | 分子名称: | CCDB, CHLORIDE ION | 著者 | Loris, R, Dao-Thi, M.-H, Bahasi, E.M, Van Melderen, L, Poortmans, F, Liddington, R, Couturier, M, Wyns, L. | 登録日 | 1998-04-17 | 公開日 | 1998-07-15 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of CcdB, a topoisomerase poison from E. coli. J.Mol.Biol., 285, 1999
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4FIS
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![BU of 4fis by Molmil](/molmil-images/mine/4fis) | THE MOLECULAR STRUCTURE OF WILD-TYPE AND A MUTANT FIS PROTEIN: RELATIONSHIP BETWEEN MUTATIONAL CHANGES AND RECOMBINATIONAL ENHANCER FUNCTION OR DNA BINDING | 分子名称: | FACTOR FOR INVERSION STIMULATION (FIS) | 著者 | Yuan, H.S, Finkel, S.E, Feng, J.-A, Johnson, R.C, Dickerson, R.E. | 登録日 | 1991-08-12 | 公開日 | 1993-10-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The molecular structure of wild-type and a mutant Fis protein: relationship between mutational changes and recombinational enhancer function or DNA binding. Proc.Natl.Acad.Sci.USA, 88, 1991
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1OC3
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![BU of 1oc3 by Molmil](/molmil-images/mine/1oc3) | HUMAN PEROXIREDOXIN 5 | 分子名称: | BENZOIC ACID, PEROXIREDOXIN 5 | 著者 | Evrard, C, Declercq, J.-P. | 登録日 | 2003-02-05 | 公開日 | 2004-02-10 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of a Dimeric Oxidized Form of Human Peroxiredoxin 5 J.Mol.Biol., 337, 2004
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2OZ6
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4MMM
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![BU of 4mmm by Molmil](/molmil-images/mine/4mmm) | Human Pdrx5 complex with a ligand BP7 | 分子名称: | 1,1'-BIPHENYL-3,4-DIOL, Peroxiredoxin-5, mitochondrial | 著者 | Guichou, J.F. | 登録日 | 2013-09-09 | 公開日 | 2014-07-30 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Comparing Binding Modes of Analogous Fragments Using NMR in Fragment-Based Drug Design: Application to PRDX5 Plos One, 9, 2014
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3TZD
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![BU of 3tzd by Molmil](/molmil-images/mine/3tzd) | Crystal structure of the complex of Human Chromobox Homolog 3 (CBX3) | 分子名称: | Chromobox protein homolog 3, Histone H1.4 | 著者 | Amaya, M.F, Ravichandran, M, Loppnau, P, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Min, J, Ouyang, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-09-27 | 公開日 | 2012-03-07 | 最終更新日 | 2013-01-23 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structural basis of the chromodomain of Cbx3 bound to methylated peptides from histone h1 and G9a. Plos One, 7, 2012
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2R3A
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![BU of 2r3a by Molmil](/molmil-images/mine/2r3a) | Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 | 分子名称: | Histone-lysine N-methyltransferase SUV39H2, S-ADENOSYLMETHIONINE, SERINE, ... | 著者 | Lunin, V.V, Wu, H, Zeng, H, Ren, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2007-08-29 | 公開日 | 2007-09-11 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural biology of human H3K9 methyltransferases Plos One, 5, 2010
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2QQG
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![BU of 2qqg by Molmil](/molmil-images/mine/2qqg) | Hst2 bound to ADP-HPD, acetyllated histone H4 and nicotinamide | 分子名称: | 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, Histone H4, NAD-dependent deacetylase HST2, ... | 著者 | Marmorstein, R, Sanders, B, Zhao, K, Slama, J. | 登録日 | 2007-07-26 | 公開日 | 2007-10-09 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes. Mol.Cell, 25, 2007
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2R57
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2RHI
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2R58
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2TSR
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![BU of 2tsr by Molmil](/molmil-images/mine/2tsr) | THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE, TOMUDEX | 著者 | Sotelo-Mundo, R.R, Ciesla, J, Dzik, J.M, Rode, W, Maley, F, Maley, G, Hardy, L.W, Montfort, W.R. | 登録日 | 1998-06-19 | 公開日 | 1999-02-16 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug. Biochemistry, 38, 1999
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5FA5
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3BTI
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2RJC
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![BU of 2rjc by Molmil](/molmil-images/mine/2rjc) | Crystal structure of L3MBTL1 protein in complex with MES | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Lethal(3)malignant brain tumor-like protein, SULFATE ION | 著者 | Allali-Hassani, A, Liu, Y, Herzanych, N, Ouyang, H, Mackenzie, F, Crombet, L, Loppnau, P, Kozieradzki, I, Vedadi, M, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J.R, Structural Genomics Consortium (SGC) | 登録日 | 2007-10-14 | 公開日 | 2007-10-30 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | L3MBTL1 recognition of mono- and dimethylated histones. Nat.Struct.Mol.Biol., 14, 2007
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2RHX
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2RJF
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![BU of 2rjf by Molmil](/molmil-images/mine/2rjf) | Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 12-30), orthorhombic form I | 分子名称: | Histone H4, Lethal(3)malignant brain tumor-like protein | 著者 | Allali-Hassani, A, Liu, Y, Herzanych, N, Ouyang, H, Mackenzie, F, Crombet, L, Loppnau, P, Kozieradzki, I, Vedadi, M, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J.R, Structural Genomics Consortium (SGC) | 登録日 | 2007-10-14 | 公開日 | 2007-10-30 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | L3MBTL1 recognition of mono- and dimethylated histones. Nat.Struct.Mol.Biol., 14, 2007
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