PDB: 5434 件ウェブページステータス検索Chemie searchBIRD

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8DP5	Structure of the PEAK3/14-3-3 complex 分子名称: 14-3-3 protein beta/alpha, 14-3-3 protein epsilon, Protein PEAK3, ... 著者 Torosyan, H, Paul, M, Jura, N, Verba, K.A. 登録日 2022-07-14 公開日 2023-06-28 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3. Nat Commun, 14, 2023
1A8B	RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE 分子名称: ANNEXIN V, CALCIUM ION, L-ALPHA-GLYCEROPHOSPHORYLETHANOLAMINE 著者 Swairjo, M.A, Concha, N.O, Kaetzel, M.A, Dedman, J.R, Seaton, B.A. 登録日 1998-03-23 公開日 1998-06-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V. Nat.Struct.Biol., 2, 1995
5UWP	Crystal Structure of mDia2 NES Peptide in complex with CRM1-Ran-RanBP1 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Fung, H.Y.J, Chook, Y.M. 登録日 2017-02-21 公開日 2017-03-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.054 Å) 主引用文献 Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
8D7U	Cereblon~DDB1 bound to CC-92480 with DDB1 in the linear conformation 分子名称: DNA damage-binding protein 1, Mezigdomide, Protein cereblon, ... 著者 Watson, E.R, Lander, G.C. 登録日 2022-06-07 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
8D81	Cereblon~DDB1 bound to Pomalidomide 分子名称: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... 著者 Watson, E.R, Lander, G.C. 登録日 2022-06-07 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
8D7Y	Cereblon-DDB1 in the Apo form with DDB1 in the twisted conformation 分子名称: DNA damage-binding protein 1, Protein cereblon, ZINC ION 著者 Watson, E.R, Lander, G.C. 登録日 2022-06-07 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
5UWO	Crystal Structure of Engineered FMRP-1b NES Peptide in complex with CRM1-Ran-RanBP1 分子名称: Engineered FMRP-1b peptide, Exportin-1, GLYCEROL, ... 著者 Fung, H.Y.J, Chook, Y.M. 登録日 2017-02-21 公開日 2017-03-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.347 Å) 主引用文献 Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
5UYZ	Structure of Human T-complex protein 1 subunit epsilon (CCT5) mutant His147Arg 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, T-complex protein 1 subunit epsilon 著者 Pereira, J.H, McAndrew, R.P, Sergeeva, O.A, Ralston, C.Y, King, J.A, Adams, P.D. 登録日 2017-02-24 公開日 2017-07-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy. Sci Rep, 7, 2017
8EYI	Atomic model of the core modifying region of human fatty acid synthase 分子名称: Fatty acid synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Hasan, S.M.N, Keszei, A, Mazhab-Jafari, M.T. 登録日 2022-10-27 公開日 2023-05-24 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Atomic model for core modifying region of human fatty acid synthase in complex with Denifanstat. Nat Commun, 14, 2023
8EYK	Atomic model of the core modifying region of human fatty acid synthase in complex with TVB-2640 分子名称: Fatty acid synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, denifanstat 著者 Hasan, S.M.N, Keszei, A, Mazhab-Jafari, M.T. 登録日 2022-10-27 公開日 2023-05-24 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Atomic model for core modifying region of human fatty acid synthase in complex with Denifanstat. Nat Commun, 14, 2023
8F93	WDR5 covalently modified at Y228 by (R)-2-SF 分子名称: 3-ethynyl-5-{[(3R)-4-{1-[(2-methoxyphenyl)methyl]-1H-benzimidazole-5-carbonyl}-3-methylpiperazin-1-yl]methyl}benzene-1-sulfonyl fluoride, CHLORIDE ION, GLYCEROL, ... 著者 Taunton, J, Craven, G.B, Chen, Y. 登録日 2022-11-23 公開日 2023-05-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. Nat.Chem., 15, 2023
5UWH	Crystal Structure of Paxillin NES Peptide in complex with CRM1-Ran-RanBP1 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Fung, H.Y.J, Chook, Y.M. 登録日 2017-02-21 公開日 2017-03-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
5V67	CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH Volasertib 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, ... 著者 EMBER, S.W, ZHU, J.-Y, SCHONBRUNN, E. 登録日 2017-03-16 公開日 2018-03-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 2021
5UYX	Structure of Human T-complex protein 1 subunit epsilon (CCT5) 分子名称: ADENOSINE-5'-DIPHOSPHATE, T-complex protein 1 subunit epsilon 著者 Pereira, J.H, McAndrew, R.P, Sergeeva, O.A, Ralston, C.Y, King, J.A, Adams, P.D. 登録日 2017-02-24 公開日 2017-07-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy. Sci Rep, 7, 2017
8EJM	Crystal structure of human DEAH-box helicase DHX15 in complex with SUGP1 G-patch 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DHX15, CHLORIDE ION, ... 著者 Huang, J, Tong, L. 登録日 2022-09-17 公開日 2022-12-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer. Proc.Natl.Acad.Sci.USA, 119, 2022
5UGH	Crystal structure of Mat2a bound to the allosteric inhibitor PF-02929366 分子名称: 2-(7-chloro-5-phenyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine, S-adenosylmethionine synthase isoform type-2 著者 Kaiser, S.E, Feng, J, Stewart, A.E. 登録日 2017-01-08 公開日 2017-05-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.062 Å) 主引用文献 Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A. Nat. Chem. Biol., 13, 2017
8EHG	Rabbit muscle aldolase determined using single-particle cryo-EM with Apollo camera. 分子名称: Fructose-bisphosphate aldolase A 著者 Peng, R, Fu, X, Mendez, J.H, Randolph, P.H, Bammes, B, Stagg, S.M. 登録日 2022-09-14 公開日 2022-12-21 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.24 Å) 主引用文献 Characterizing the resolution and throughput of the Apollo direct electron detector. J Struct Biol X, 7, 2023
1ZKF	Cyrstal Structure of Human Cyclophilin-A in Complex with suc-AGPF-pNA 分子名称: Peptidyl-prolyl cis-trans isomerase A, Suc-ALA-GLY-PRO-PHE-pNA 著者 Eisenmesser, E.Z, Thai, V, Pozharski, E, Kern, D. 登録日 2005-05-02 公開日 2006-04-11 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Mechanistic Insights of Cyclophilin-A from X-Ray Cyrstallographic and Nuclear Magnet Resonance Investigations To be Published
8EW2	Cryo-EM structure of Aldolase embedded in crystalline ice 分子名称: Fructose-bisphosphate aldolase A 著者 Shi, H, Wu, C, Zhang, X. 登録日 2022-10-21 公開日 2023-01-11 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Addressing compressive deformation of proteins embedded in crystalline ice. Structure, 31, 2023
1ZMZ	Solution structure of the N-terminal domain (M1-S98) of human centrin 2 分子名称: Centrin-2 著者 Yang, A, Miron, S, Duchambon, P, Assairi, L, Blouquit, Y, Craescu, C.T. 登録日 2005-05-11 公開日 2006-04-25 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 The N-terminal domain of human centrin 2 has a closed structure, binds calcium with a very low affinity, and plays a role in the protein self-assembly Biochemistry, 45, 2006
8F1G	Crystal structure of human WDR5 in complex with compound WM662 分子名称: (2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid, GLYCEROL, SULFATE ION, ... 著者 Liu, H. 登録日 2022-11-05 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. Acs Chem.Biol., 18, 2023
8EOM	TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-5973 分子名称: 4-(4-methylpiperazine-1-sulfonyl)benzamide, SULFATE ION, TP53-binding protein 1, ... 著者 The, J, Hong, Z, Headey, S, Gunzburg, M, Doak, B, James, L.I, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) 登録日 2022-10-03 公開日 2023-01-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-5973 to be published
1AWR	CYPA COMPLEXED WITH HAGPIA 分子名称: CYCLOPHILIN A, PEPTIDE FROM THE HIV-1 CAPSID PROTEIN 著者 Vajdos, F.F. 登録日 1997-10-04 公開日 1998-03-18 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein. Protein Sci., 6, 1997
8EAD	Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-177 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-{2-chloro-5-[(5-methyl-2-{4-[2-(pyrrolidin-1-yl)ethoxy]anilino}pyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide 著者 Karim, M.R, Schonbrunn, E. 登録日 2022-08-29 公開日 2022-09-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-177 To Be Published
5UWT	Crystal Structure of Hxk2 Peptide in complex with CRM1 K579A mutant-Ran-RanBP1 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Fung, H.Y.J, Chook, Y.M. 登録日 2017-02-21 公開日 2017-03-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.342 Å) 主引用文献 Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017

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