1A8B

RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE

Summary for 1A8B

• Entry DOI: 10.2210/pdb1a8b/pdb
• Descriptor: ANNEXIN V, CALCIUM ION, L-ALPHA-GLYCEROPHOSPHORYLETHANOLAMINE, ... (4 entities in total)
• Functional Keywords: phospholipid analog, calcium binding protein, membrane binding protein
• Biological source: Rattus norvegicus (Norway rat)
• Total number of polymer chains: 1
• Total formula weight: 36299.22

Authors

Swairjo, M.A.,Concha, N.O.,Kaetzel, M.A.,Dedman, J.R.,Seaton, B.A. (deposition date: 1998-03-23, release date: 1998-06-17, Last modification date: 2024-10-23)

Primary citation

Swairjo, M.A.,Concha, N.O.,Kaetzel, M.A.,Dedman, J.R.,Seaton, B.A.
Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V.
Nat.Struct.Biol., 2:968-974, 1995

PubMed Abstract: Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.

PubMed: 7583670
DOI: 10.1038/nsb1195-968

Experimental method

X-RAY DIFFRACTION (1.9 Å)