PDB: 242842 件ウェブページステータス検索Chemie searchBIRD

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1KX3	X-Ray Structure of the Nucleosome Core Particle, NCP146, at 2.0 A Resolution 分子名称: DNA (5'(ATCAATATCCACCTGCAGATTCTACCAAAAGTGTATTTGGAAACTGCTCCATCAAAAGGCATGTTCAGCTGAATTCAGCTGAACATGCCTTTTGATGGAGCAGTTTCCAAATACACTTTTGGTAGAATCTGCAGGTGGATATTGAT)3'), MANGANESE (II) ION, histone H2A.1, ... 著者 Davey, C.A, Sargent, D.F, Luger, K, Maeder, A.W, Richmond, T.J. 登録日 2002-01-31 公開日 2002-12-25 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Solvent Mediated Interactions in the Structure of the Nucleosome Core Particle at 1.9 A Resolution J.Mol.Biol., 319, 2002
3U3Y	Mouse TREX1 D200H mutant 分子名称: 1,4-BUTANEDIOL, 5'-D(*GP*AP*CP*G)-3', CALCIUM ION, ... 著者 Bailey, S.L, Harvey, S, Perrino, F.W, Hollis, T. 登録日 2011-10-06 公開日 2011-12-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease. Dna Repair, 11, 2012
4N1O	Structure of Cyclophilin A in complex with Saccharin. 分子名称: 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, Peptidyl-prolyl cis-trans isomerase A 著者 Mcnae, I.W, Dornan, J, Walkinshaw, M.D. 登録日 2013-10-04 公開日 2015-08-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Mapping the binding surface of Cyclophilin A. To be Published
7OAT	Structural basis for targeted p97 remodelling by ASPL as prerequisite for p97 trimethylation by METTL21D 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Petrovic, S, Heinemann, U, Roske, Y. 登録日 2021-04-20 公開日 2022-08-03 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.995 Å) 主引用文献 Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D. Proc.Natl.Acad.Sci.USA, 120, 2023
3HJZ	The structure of an aldolase from Prochlorococcus marinus 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Singer, A.U, Xu, X, Cui, H, Joachimiak, A, Edwards, A.M, Savchenko, A, Midwest Center for Structural Genomics (MCSG) 登録日 2009-05-22 公開日 2009-06-09 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Phage auxiliary metabolic genes and the redirection of cyanobacterial host carbon metabolism. Proc.Natl.Acad.Sci.USA, 108, 2011
4Y5H	Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors 分子名称: 1-(trans-4-{[7-oxo-8-(propan-2-yl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}cyclohexyl)-3-propan-2-ylurea, Mitogen-activated protein kinase 10 著者 Park, H. 登録日 2015-02-11 公開日 2015-05-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.055 Å) 主引用文献 Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors. Acs Med.Chem.Lett., 6, 2015
1U8K	Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide LELDKWASL 分子名称: ANTIBODY 2F5 (HEAVY CHAIN), ANTIBODY 2F5 (LIGHT CHAIN), GP41 PEPTIDE 著者 Bryson, S, Julien, J.-P, Pai, E.F. 登録日 2004-08-06 公開日 2004-10-05 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptides and Peptide Mimetics To be Published
6SIM	SAD structure of Hen Egg White Lysozyme recovered by inverse beam geometry data collection and univariate analysis 分子名称: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... 著者 Garcia-Bonete, M.J, Katona, G. 登録日 2019-08-10 公開日 2019-11-06 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.61018026 Å) 主引用文献 Bayesian machine learning improves single-wavelength anomalous diffraction phasing. Acta Crystallogr.,Sect.A, 75, 2019
6SIS	Crystal structure of macrocyclic PROTAC 1 in complex with the second bromodomain of human Brd4 and pVHL:ElonginC:ElonginB 分子名称: Bromodomain-containing protein 4, Elongin-B, Elongin-C, ... 著者 Hughes, S.J, Testa, A, Ciulli, A. 登録日 2019-08-10 公開日 2019-12-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure-Based Design of a Macrocyclic PROTAC. Angew.Chem.Int.Ed.Engl., 59, 2020
4ECP	X-ray crystal structure of Inorganic Pyrophosphate PPA from Mycobacterium leprae 分子名称: 1,2-ETHANEDIOL, Inorganic pyrophosphatase 著者 SSGCID, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-03-26 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 X-ray crystal structure of Inorganic Pyrophosphate PPA from Mycobacterium leprae TO BE PUBLISHED
6SXR	E221Q mutant of GH54 a-l-arabinofuranosidase soaked with 4-nitrophenyl a-l-arabinofuranoside 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 McGregor, N.G.S, Davies, G.J, Nin-Hill, A, Rovira, C. 登録日 2019-09-26 公開日 2020-02-26 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining alpha-l-Arabinofuranosidases. J.Am.Chem.Soc., 142, 2020
7OKC	Crystal structure of Escherichia coli LpxA in complex with compound 1 分子名称: 2-[2-(2-chlorophenyl)sulfanylethanoyl-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]amino]-N-methyl-ethanamide, Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, SODIUM ION 著者 Ryan, M.D, Parkes, A.L, Southey, M, Andersen, O.A, Zahn, M, Barker, J, DeJonge, B.L.M. 登録日 2021-05-17 公開日 2021-10-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Discovery of Novel UDP- N -Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa . J.Med.Chem., 64, 2021
3TOA	Human MOF crystal structure with active site lysine partially acetylated 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, ZINC ION, ... 著者 Yuan, H, Ding, E.C, Marmorstein, R. 登録日 2011-09-04 公開日 2011-11-09 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (3.004 Å) 主引用文献 MYST protein acetyltransferase activity requires active site lysine autoacetylation. Embo J., 31, 2011
6SP5	Structure of hyperstable haloalkane dehalogenase variant DhaA115 分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Haloalkane dehalogenase, ... 著者 Chmelova, K, Markova, K, Damborsky, J, Marek, M. 登録日 2019-08-30 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Decoding the intricate network of molecular interactions of a hyperstable engineered biocatalyst. Chem Sci, 11, 2020
4N5V	Alternative substrates of Mycobacterium tuberculosis anthranilate phosphoribosyl transferase 分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-amino-4-fluorobenzoic acid, Anthranilate phosphoribosyltransferase, ... 著者 Castell, A, Cookson, T.V.M, Parker, E.J, Baker, E.N, Lott, J.S. 登録日 2013-10-10 公開日 2014-04-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis. Biochem.J., 461, 2014
6DOG	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 200 mM K+ for 600 s at 21 C 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*AP*TP*GP*T)-3'), GLYCEROL, ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.285 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
6DP7	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 500 mM Mn2+ and 200 mM K+ for 40 s at 21 C 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*AP*TP*GP*T)-3'), IODIDE ION, ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.381 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
6DPN	Crystal Structure of Bacillus Halodurans Ribonuclease H1 E188A in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 200 mM K+ for 200 s at 21 C 分子名称: 1,2-ETHANEDIOL, 5'-R(*AP*CP*AP*U)-3' portion of intact RNA (5'-R(*AP*CP*AP*UP*CP*G)-3'), 5'-R(P*CP*G)-3' portion of intact RNA (5'-R(*AP*CP*AP*UP*CP*G)-3'), ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.493 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
6DPD	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 16 mM Mn2+ and 200 mM K+ for 40 s at 21 C 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*AP*TP*GP*T)-3'), GLYCEROL, ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
7ORZ	Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 18) 分子名称: 1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Acebron-Garcia de Eulate, M, Blundell, T.L, Kim, S.Y, Mendes, V, Abell, C. 登録日 2021-06-06 公開日 2021-11-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Discovery of Novel Inhibitors of Uridine Diphosphate- N -Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa , an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients. J.Med.Chem., 65, 2022
3TZU	Crystal structure of a glycine cleavage system H protein (GCVH) from Mycobacterium marinum 分子名称: 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2011-09-27 公開日 2011-10-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
4N02	Type 2 IDI from S. pneumoniae 分子名称: 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, Isopentenyl-diphosphate delta-isomerase, SULFATE ION 著者 de Ruyck, J, Schubert, H.L, Poulter, C.D. 登録日 2013-09-30 公開日 2014-07-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Determination of Kinetics and the Crystal Structure of a Novel Type 2 Isopentenyl Diphosphate: Dimethylallyl Diphosphate Isomerase from Streptococcus pneumoniae. Chembiochem, 15, 2014
7O7K	Crystal structure of the human DYRK1A kinase domain bound to abemaciclib 分子名称: 1,2-ETHANEDIOL, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... 著者 Kaltheuner, I.H, Anand, K, Geyer, M. 登録日 2021-04-13 公開日 2021-11-24 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation. Nat Commun, 12, 2021
3U2D	S. aureus GyrB ATPase domain in complex with small molecule inhibitor 分子名称: 4-bromo-5-methyl-N-[1-(3-nitropyridin-2-yl)piperidin-4-yl]-1H-pyrrole-2-carboxamide, DNA gyrase subunit B, MAGNESIUM ION 著者 Boriack-Sjodin, P.A, Prince, D.B, Eakin, A.E, Sherer, B.A. 登録日 2011-10-03 公開日 2012-01-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents. Antimicrob.Agents Chemother., 56, 2012
6ZZ3	RBcel1 cellulase variant Y201F with cellotriose covalently bound 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endoglucanase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose 著者 Collet, L, Dutoit, R. 登録日 2020-08-03 公開日 2021-07-21 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.095 Å) 主引用文献 Glycoside hydrolase family 5: structural snapshots highlighting the involvement of two conserved residues in catalysis. Acta Crystallogr D Struct Biol, 77, 2021

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