7OAT

Structural basis for targeted p97 remodelling by ASPL as prerequisite for p97 trimethylation by METTL21D

Summary for 7OAT

Entry DOI	10.2210/pdb7oat/pdb
Descriptor	Tether containing UBX domain for GLUT4, Transitional endoplasmic reticulum ATPase, Protein-lysine methyltransferase METTL21D, ... (8 entities in total)
Functional Keywords	p97, aaa+ atpase, aspl, mettl21d, vcp-kmt, vcp, methylation, remodelling, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	101509.79
Authors	Petrovic, S.,Heinemann, U.,Roske, Y. (deposition date: 2021-04-20, release date: 2022-08-03, Last modification date: 2024-02-07)
Primary citation	Petrovic, S.,Roske, Y.,Rami, B.,Phan, M.H.Q.,Panakova, D.,Heinemann, U. Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D. Proc.Natl.Acad.Sci.USA, 120:e2208941120-e2208941120, 2023 Cited by PubMed: 36656859 DOI: 10.1073/pnas.2208941120 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.995 Å)

Structure validation