7OAT
Structural basis for targeted p97 remodelling by ASPL as prerequisite for p97 trimethylation by METTL21D
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0005524 | molecular_function | ATP binding |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006479 | biological_process | protein methylation |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0008276 | molecular_function | protein methyltransferase activity |
| C | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0018022 | biological_process | peptidyl-lysine methylation |
| C | 0018023 | biological_process | peptidyl-lysine trimethylation |
| C | 0032259 | biological_process | methylation |
| C | 0032780 | biological_process | negative regulation of ATP-dependent activity |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0051117 | molecular_function | ATPase binding |
Functional Information from PROSITE/UniProt
| site_id | PS00674 |
| Number of Residues | 19 |
| Details | AAA AAA-protein family signature. ViVMaATNrpnsIDpALr.R |
| Chain | Residue | Details |
| B | VAL341-ARG359 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 76 |
| Details | Domain: {"description":"UBX","evidences":[{"source":"PROSITE-ProRule","id":"PRU00215","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20512113","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6,N6,N6-trimethyllysine; by VCPKMT","evidences":[{"source":"PubMed","id":"22948820","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23349634","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)","evidences":[{"source":"PubMed","id":"38762759","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2013","submissionDatabase":"PDB data bank","title":"The crystal structure of human methyltransferase-like protein 21D in complex with SAM.","authors":["Zeng H.","Dong A.","Fenner M.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Brown P.J.","Wu H."]}}]} |
| Chain | Residue | Details |
