PDB: 313 件ウェブページステータス検索Chemie searchBIRD

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6N61	Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA and Capistruin 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Capistruin, ... 著者 Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A. 登録日 2018-11-24 公開日 2019-01-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.253 Å) 主引用文献 Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6N60	Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA and Microcin J25 (MccJ25) 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A. 登録日 2018-11-23 公開日 2019-01-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.68 Å) 主引用文献 Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6EYD	Structure of Mycobacterium smegmatis RNA polymerase Sigma-A holoenzyme 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Kouba, T, Barvik, I, Krasny, L. 登録日 2017-11-11 公開日 2018-12-12 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.22 Å) 主引用文献 The Core and Holoenzyme Forms of RNA Polymerase fromMycobacterium smegmatis. J. Bacteriol., 201, 2019
6EEC	Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3 promoter captured by Corallopyronin 分子名称: DNA (63-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. 登録日 2018-08-13 公開日 2018-11-21 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.55 Å) 主引用文献 Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
6EDT	Mycobacterium tuberculosis RNAP open promoter complex with RbpA/CarD and AP3 promoter 分子名称: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. 登録日 2018-08-10 公開日 2018-11-21 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY 主引用文献 Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
6M7J	Mycobacterium tuberculosis RNAP with RbpA/us fork and Corallopyronin 分子名称: DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. 登録日 2018-08-20 公開日 2018-11-21 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
6EE8	Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3 promoter 分子名称: DNA (60-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. 登録日 2018-08-13 公開日 2018-11-21 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.92 Å) 主引用文献 Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
6DCF	Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and bound to kanglemycin A 分子名称: 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... 著者 Lilic, M, Darst, S.A, Campbell, E.A. 登録日 2018-05-06 公開日 2018-09-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
6CCE	Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with inhibitor Kanglemycin A 分子名称: 1,2-ETHANEDIOL, DNA (57-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Lilic, M, Darst, S.A, Campbell, E.A. 登録日 2018-02-07 公開日 2018-08-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
6CCV	Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with inhibitor Rifampicin 分子名称: 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... 著者 Lilic, M, Darst, S.A, Campbell, E.A. 登録日 2018-02-07 公開日 2018-08-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
6CUX	Escherichia coli RpoB S531L mutant RNA polymerase holoenzyme in complex with Kanglemycin A 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Molodtsov, V, Murakami, K.S. 登録日 2018-03-26 公開日 2018-07-25 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (4.104 Å) 主引用文献 Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mol. Cell, 72, 2018
6CUU	Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic Kanglemycin A 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*CP*TP*CP*TP*GP*AP*TP*GP*CP*A)-3'), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Molodtsov, V, Murakami, K.S. 登録日 2018-03-26 公開日 2018-07-25 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.994 Å) 主引用文献 Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mol. Cell, 72, 2018
6FI7	E.coli Sigma factor S (RpoS) Region 4 分子名称: RNA polymerase sigma factor RpoS 著者 Liu, B, Matthews, S.J. 登録日 2018-01-17 公開日 2018-06-06 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 T7 phage factor required for managing RpoS inEscherichia coli. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BZO	Mtb RNAP Holo/RbpA/Fidaxomicin/upstream fork DNA 分子名称: DNA (26-MER), DNA (32-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. 登録日 2017-12-25 公開日 2018-03-28 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.38 Å) 主引用文献 Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
6C06	Mycobacterium tuberculosis RNAP Holo/RbpA/Fidaxomicin 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M. 登録日 2017-12-27 公開日 2018-03-28 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (5.15 Å) 主引用文献 Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
6C05	Mycobacterium tuberculosis RNAP Holo/RbpA in relaxed state 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M. 登録日 2017-12-27 公開日 2018-03-28 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (5.15 Å) 主引用文献 Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
6C04	Mtb RNAP Holo/RbpA/double fork DNA -closed clamp 分子名称: DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M. 登録日 2017-12-27 公開日 2018-03-28 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
6FBV	Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with Fidaxomicin 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Das, K, Lin, W, Ebright, E. 登録日 2017-12-19 公開日 2018-02-28 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.52 Å) 主引用文献 Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Mol. Cell, 70, 2018
6C9Y	Cryo-EM structure of E. coli RNAP sigma70 holoenzyme 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Narayanan, A, Vago, F, Li, K, Qayyum, M.Z, Yenool, D, Jiang, W, Murakami, K.S. 登録日 2018-01-29 公開日 2018-02-28 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.25 Å) 主引用文献 Cryo-EM structure ofEscherichia colisigma70RNA polymerase and promoter DNA complex revealed a role of sigma non-conserved region during the open complex formation. J. Biol. Chem., 293, 2018
6CA0	Cryo-EM structure of E. coli RNAP sigma70 open complex 分子名称: DNA (35-MER), DNA (45-MER), DNA (5'-D(P*GP*CP*CP*GP*CP*GP*TP*CP*AP*GP*A)-3'), ... 著者 Narayanan, A, Vago, F, Li, K, Qayyum, M.Z, Yernool, D, Jiang, W, Murakami, K.S. 登録日 2018-01-29 公開日 2018-02-28 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (5.75 Å) 主引用文献 Cryo-EM structure ofEscherichia colisigma70RNA polymerase and promoter DNA complex revealed a role of sigma non-conserved region during the open complex formation. J. Biol. Chem., 293, 2018
6BYU	X-ray crystal structure of Escherichia coli RNA polymerase (RpoB-H526Y) and ppApp complex 分子名称: (5R)-5-(6-amino-9H-purin-9-yl)-2-({[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}methyl)-4-oxo-4,5-dihydrofuran-3-yl trihydrogen diphosphate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Murakami, K.S, Molodtsov, V. 登録日 2017-12-21 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structure-function comparisons of (p)ppApp vs (p)ppGpp for Escherichia coli RNA polymerase binding sites and for rrnB P1 promoter regulatory responses in vitro. Biochim. Biophys. Acta, 1861, 2018
5XJ0	T. thermophilus RNA polymerase holoenzyme bound with gp39 and gp76 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Ooi, W.Y, Murayama, Y, Mekler, V, Minakhin, L, Severinov, K, Yokoyama, S, Sekine, S. 登録日 2017-04-28 公開日 2017-12-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (4.004 Å) 主引用文献 A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation Nucleic Acids Res., 46, 2018
6B6H	The cryo-EM structure of a bacterial class I transcription activation complex 分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Liu, B, Hong, C, Huang, R, Yu, Z, Steitz, T.A. 登録日 2017-10-02 公開日 2017-11-15 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural basis of bacterial transcription activation. Science, 358, 2017
5VT0	Escherichia coli 6S RNA derivative in complex with Escherichia coli RNA polymerase sigma70-holoenzyme 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Chen, J, Darst, S.A. 登録日 2017-05-15 公開日 2017-11-01 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.78 Å) 主引用文献 6S RNA Mimics B-Form DNA to Regulate Escherichia coli RNA Polymerase. Mol. Cell, 68, 2017
5VI5	Structure of Mycobacterium smegmatis transcription initiation complex with a full transcription bubble 分子名称: 1,2-ETHANEDIOL, DNA (44-MER), DNA (49-MER), ... 著者 Darst, S.A, Campbell, E.A, Lilic, M. 登録日 2017-04-14 公開日 2017-07-26 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.196 Å) 主引用文献 Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures. Nat Commun, 8, 2017

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