6PM2
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![BU of 6pm2 by Molmil](/molmil-images/mine/6pm2) | CryoEM structure of zebra fish alpha-1 glycine receptor bound with Taurine in SMA, open state | 分子名称: | 2-AMINOETHANESULFONIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-02-10 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PM5
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![BU of 6pm5 by Molmil](/molmil-images/mine/6pm5) | CryoEM structure of zebra fish alpha-1 glycine receptor bound with Glycine in SMA, desensitized state | 分子名称: | GLYCINE, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-02-10 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLP
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![BU of 6plp by Molmil](/molmil-images/mine/6plp) | CryoEM structure of zebra fish alpha-1 glycine receptor YGF mutant bound with GABA in SMA, desensitized state | 分子名称: | GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-02-10 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PM6
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![BU of 6pm6 by Molmil](/molmil-images/mine/6pm6) | CryoEM structure of zebra fish alpha-1 glycine receptor bound with Glycine in SMA, open state | 分子名称: | GLYCINE, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-02-10 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLW
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![BU of 6plw by Molmil](/molmil-images/mine/6plw) | CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA, super-open state | 分子名称: | GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-02-10 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6NP0
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![BU of 6np0 by Molmil](/molmil-images/mine/6np0) | Cryo-EM structure of 5HT3A receptor in presence of granisetron | 分子名称: | 1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Basak, S, Chakrapani, S. | 登録日 | 2019-01-17 | 公開日 | 2019-07-24 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Molecular mechanism of setron-mediated inhibition of full-length 5-HT3Areceptor. Nat Commun, 10, 2019
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6QFA
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![BU of 6qfa by Molmil](/molmil-images/mine/6qfa) | CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit beta-3, HISTAMINE, ... | 著者 | Uchanski, T, Masiulis, S, Fischer, B, Kalichuk, V, Wohlkoening, A, Zoegg, T, Remaut, H, Vranken, W, Aricescu, A.R, Pardon, E, Steyaert, J. | 登録日 | 2019-01-09 | 公開日 | 2021-08-04 | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | 主引用文献 | Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM. Nat.Methods, 18, 2021
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6I53
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![BU of 6i53 by Molmil](/molmil-images/mine/6i53) | Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with Megabody38 in a lipid nanodisc | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1, ... | 著者 | Laverty, D, Desai, R, Uchanski, T, Masiulis, S, Wojciech, J.S, Malinauskas, T, Zivanov, J, Pardon, E, Steyaert, J, Miller, K.W, Aricescu, A.R. | 登録日 | 2018-11-12 | 公開日 | 2019-01-02 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structure of the human alpha 1 beta 3 gamma 2 GABAAreceptor in a lipid bilayer. Nature, 565, 2019
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6HUO
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![BU of 6huo by Molmil](/molmil-images/mine/6huo) | CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with alprazolam (Xanax), GABA and megabody Mb38. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R. | 登録日 | 2018-10-09 | 公開日 | 2019-01-02 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | GABAAreceptor signalling mechanisms revealed by structural pharmacology. Nature, 565, 2019
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6HUP
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![BU of 6hup by Molmil](/molmil-images/mine/6hup) | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with diazepam (Valium), GABA and megabody Mb38. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-CHLORO-1-METHYL-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R. | 登録日 | 2018-10-09 | 公開日 | 2019-01-02 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | GABAAreceptor signalling mechanisms revealed by structural pharmacology. Nature, 565, 2019
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6HUG
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![BU of 6hug by Molmil](/molmil-images/mine/6hug) | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and megabody Mb38. | 分子名称: | (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1, ... | 著者 | Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R. | 登録日 | 2018-10-08 | 公開日 | 2019-01-02 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | GABAAreceptor signalling mechanisms revealed by structural pharmacology. Nature, 565, 2019
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6HUJ
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![BU of 6huj by Molmil](/molmil-images/mine/6huj) | CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with picrotoxin, GABA and megabody Mb38. | 分子名称: | (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R. | 登録日 | 2018-10-08 | 公開日 | 2019-01-02 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | GABAAreceptor signalling mechanisms revealed by structural pharmacology. Nature, 565, 2019
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6HUK
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![BU of 6huk by Molmil](/molmil-images/mine/6huk) | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and megabody Mb38. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit beta-3, ... | 著者 | Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R. | 登録日 | 2018-10-08 | 公開日 | 2019-01-02 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.69 Å) | 主引用文献 | GABAAreceptor signalling mechanisms revealed by structural pharmacology. Nature, 565, 2019
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6HIN
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![BU of 6hin by Molmil](/molmil-images/mine/6hin) | Mouse serotonin 5-HT3 receptor, serotonin-bound, F conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | 著者 | Polovinkin, L, Neumann, E, Schoehn, G, Nury, H. | 登録日 | 2018-08-30 | 公開日 | 2018-11-07 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Conformational transitions of the serotonin 5-HT3receptor. Nature, 563, 2018
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6HIQ
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![BU of 6hiq by Molmil](/molmil-images/mine/6hiq) | Mouse serotonin 5-HT3 receptor, serotonin-bound, I2 conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | 著者 | Polovinkin, L, Neumann, E, Schoehn, G, Nury, H. | 登録日 | 2018-08-30 | 公開日 | 2018-11-07 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Conformational transitions of the serotonin 5-HT3receptor. Nature, 563, 2018
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6HIO
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![BU of 6hio by Molmil](/molmil-images/mine/6hio) | Mouse serotonin 5-HT3 receptor, serotonin-bound, I1 conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | 著者 | Polovinkin, L, Neumann, E, Schoehn, G, Nury, H. | 登録日 | 2018-08-30 | 公開日 | 2018-11-07 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Conformational transitions of the serotonin 5-HT3receptor. Nature, 563, 2018
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6HIS
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![BU of 6his by Molmil](/molmil-images/mine/6his) | Mouse serotonin 5-HT3 receptor, tropisetron-bound, T conformation | 分子名称: | (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-INDOLE-3-CARBOXYLATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | 著者 | Polovinkin, L, Neumann, E, Schoehn, G, Nury, H. | 登録日 | 2018-08-30 | 公開日 | 2018-11-07 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Conformational transitions of the serotonin 5-HT3receptor. Nature, 563, 2018
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6A96
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![BU of 6a96 by Molmil](/molmil-images/mine/6a96) | Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-5,Gamma-aminobutyric acid receptor subunit alpha-5, ... | 著者 | Liu, S, Xu, L, Guan, F, Liu, Y.T, Cui, Y, Zhang, Q, Bi, G.Q, Zhou, Z.H, Zhang, X, Ye, S. | 登録日 | 2018-07-11 | 公開日 | 2018-10-03 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | Cryo-EM structure of the human alpha 5 beta 3 GABAAreceptor. Cell Res., 28, 2018
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6DW0
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![BU of 6dw0 by Molmil](/molmil-images/mine/6dw0) | Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (Whole map) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, ... | 著者 | Phulera, S, Zhu, H, Yu, J, Yoshioka, C, Gouaux, E. | 登録日 | 2018-06-26 | 公開日 | 2018-08-08 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structure of the benzodiazepine-sensitive alpha 1 beta 1 gamma 2S tri-heteromeric GABAAreceptor in complex with GABA. Elife, 7, 2018
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6DW1
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![BU of 6dw1 by Molmil](/molmil-images/mine/6dw1) | Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (ECD map) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, ... | 著者 | Phulera, S, Zhu, H, Yu, J, Yoshioka, C, Gouaux, E. | 登録日 | 2018-06-26 | 公開日 | 2018-08-08 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM structure of the benzodiazepine-sensitive alpha 1 beta 1 gamma 2S tri-heteromeric GABAAreceptor in complex with GABA. Elife, 7, 2018
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6DG8
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![BU of 6dg8 by Molmil](/molmil-images/mine/6dg8) | |
6DG7
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![BU of 6dg7 by Molmil](/molmil-images/mine/6dg7) | |
6D6U
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![BU of 6d6u by Molmil](/molmil-images/mine/6d6u) | Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Zhu, S, Noviello, C.M, Teng, J, Walsh Jr, R.M, Kim, J.J, Hibbs, R.E. | 登録日 | 2018-04-22 | 公開日 | 2018-06-27 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | 主引用文献 | Structure of a human synaptic GABAAreceptor. Nature, 559, 2018
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6D6T
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![BU of 6d6t by Molmil](/molmil-images/mine/6d6t) | Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation B | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Zhu, S, Noviello, C.M, Teng, J, Walsh Jr, R.M, Kim, J.J, Hibbs, R.E. | 登録日 | 2018-04-22 | 公開日 | 2018-06-27 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | 主引用文献 | Structure of a human synaptic GABAAreceptor. Nature, 559, 2018
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6D1S
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![BU of 6d1s by Molmil](/molmil-images/mine/6d1s) | Crystal structure of an apo chimeric human alpha1GABAA receptor | 分子名称: | chimeric alpha1GABAA receptor | 著者 | Chen, Q, Arjunan, P, Cohen, A.E, Xu, Y, Tang, P. | 登録日 | 2018-04-12 | 公開日 | 2018-08-22 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis of neurosteroid anesthetic action on GABAAreceptors. Nat Commun, 9, 2018
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