8BWH
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8BWE
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8BTQ
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6ZBT
| Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser342 | 分子名称: | 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, E3 ubiquitin-protein ligase NEDD4-like | 著者 | Joshi, R, Kalabova, D, Obsil, T, Obsilova, V. | 登録日 | 2020-06-09 | 公開日 | 2021-07-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.79948521 Å) | 主引用文献 | 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021
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6ZC9
| Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser448 | 分子名称: | 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, E3 ubiquitin-protein ligase NEDD4-like | 著者 | Pohl, P, Kalabova, D, Obsil, T, Obsilova, V. | 登録日 | 2020-06-10 | 公開日 | 2021-07-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.89895988 Å) | 主引用文献 | 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021
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8C2G
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8C3C
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8C2D
| 14-3-3 in complex with Pyrin pS208 | 分子名称: | 14-3-3 protein sigma, MAGNESIUM ION, Pyrin pS208 peptide | 著者 | Lau, R, Ottmann, C, Hann, M. | 登録日 | 2022-12-22 | 公開日 | 2023-07-26 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystal structure and ligandability of the 14-3-3/pyrin interface. Biochem.Biophys.Res.Commun., 651, 2023
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8C04
| Co-soaked stabilizers for ERa - 14-3-3 interaction (884_AZ354) | 分子名称: | 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, ... | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | 登録日 | 2022-12-15 | 公開日 | 2023-08-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8BZA
| single soak stabilizer for ERa - 14-3-3 interaction (AZ555) | 分子名称: | 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | 登録日 | 2022-12-14 | 公開日 | 2023-08-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8BYO
| fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361) | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... | 著者 | Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. | 登録日 | 2023-01-18 | 公開日 | 2023-08-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8BZ0
| single soak stabilizer for ERa - 14-3-3 interaction (AZ275) | 分子名称: | 14-3-3 protein sigma, 4-ethoxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | 登録日 | 2022-12-14 | 公開日 | 2023-08-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8C4F
| Small molecule amidine soak in 14-3-3/ERa (AZ037) | 分子名称: | 14-3-3 protein sigma, 5-(cyclohexylamino)-4-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | 登録日 | 2023-01-03 | 公開日 | 2023-08-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8BYY
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8BZW
| Co-soaked stabilizers for ERa - 14-3-3 interaction (844_AZ210) | 分子名称: | 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-[(2~{R})-3-azanyl-2-methyl-propyl]-7-methoxy-1-benzothiophene-2-carboximidamide, ... | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | 登録日 | 2022-12-15 | 公開日 | 2023-08-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8C4G
| Small molecule amidine soak in 14-3-3/ERa (AZ132) | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | 登録日 | 2023-01-03 | 公開日 | 2023-08-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8BZB
| co-soak stabilizers for ERa - 14-3-3 interaction (884_AZ275) | 分子名称: | 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-ethoxy-1-benzothiophene-2-carboximidamide, ... | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | 登録日 | 2022-12-14 | 公開日 | 2023-08-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8C0K
| fragment-linked stabilizer for ERa - 14-3-3 interaction (1075302) | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... | 著者 | Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. | 登録日 | 2022-12-17 | 公開日 | 2023-08-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8BYZ
| fragment-linked stabilizer for ERa - 14-3-3 interaction (AZ210) | 分子名称: | 14-3-3 protein sigma, 4-[(2~{S})-3-azanyl-2-methyl-propyl]-7-methoxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | 登録日 | 2022-12-14 | 公開日 | 2023-08-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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6ZVC
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6ZVB
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8BZ9
| single soak stabilizer for ERa - 14-3-3 interaction (AZ354) | 分子名称: | 14-3-3 protein sigma, 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | 登録日 | 2022-12-14 | 公開日 | 2023-08-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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6ZVD
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6ZVE
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7A6Y
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