6ASC
 
 | | Mre11 dimer in complex with Endonuclease inhibitor PFM04 | | 分子名称: | (5E)-3-butyl-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, 1,2-ETHANEDIOL, MANGANESE (II) ION, ... | | 著者 | Moiani, D, Arvai, A.S, Tainer, J.A. | | 登録日 | 2017-08-24 | | 公開日 | 2018-03-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities.
Meth. Enzymol., 601, 2018
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1G5B
 | | BACTERIOPHAGE LAMBDA SER/THR PROTEIN PHOSPHATASE | | 分子名称: | MANGANESE (II) ION, MERCURY (II) ION, SERINE/THREONINE PROTEIN PHOSPHATASE, ... | | 著者 | Voegtli, W.C, White, D.J, Reiter, N.J, Rusnak, F, Rosenzweig, A.C. | | 登録日 | 2000-10-31 | | 公開日 | 2001-03-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structure of the bacteriophage lambda Ser/Thr protein phosphatase with sulfate ion bound in two coordination modes.
Biochemistry, 39, 2000
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6Z9B
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7TVF
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5K77
 | | Dbr1 in complex with 7-mer branched RNA | | 分子名称: | FE (II) ION, HYDROXIDE ION, RNA lariat debranching enzyme, ... | | 著者 | Clark, N.E, Taylor, A.B, Hart, P.J. | | 登録日 | 2016-05-25 | | 公開日 | 2016-12-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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7D0V
 | | Crystal structure of Taiwan cobra 5'-nucleotidase | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Snake venom 5'-nucleotidase, ... | | 著者 | Tsai, M.-H, Lin, I.-J, Lin, C.-C, Wu, W.-G. | | 登録日 | 2020-09-12 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.175 Å) | | 主引用文献 | Crystal structure of Taiwan cobra 5'-nucleotidase
To Be Published
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4UT3
 | | X-ray structure of the human PP1 gamma catalytic subunit treated with hydrogen peroxide | | 分子名称: | MANGANESE (II) ION, PHOSPHATE ION, SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT | | 著者 | Zeh Silva, M, Kopec, J, Fotinou, D, Steiner, R.A. | | 登録日 | 2014-07-17 | | 公開日 | 2015-07-22 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Targeted Redox Inhibition of Protein Phosphatase 1 by Nox4 Regulates Eif2Alpha-Mediated Stress Signaling.
Embo J., 35, 2016
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4MOY
 | | Structure of a second nuclear PP1 Holoenzyme, crystal form 1 | | 分子名称: | CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ... | | 著者 | Choy, M.S, Hieke, M, Peti, W, Page, R. | | 登録日 | 2013-09-12 | | 公開日 | 2014-03-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.1953 Å) | | 主引用文献 | Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code.
Proc.Natl.Acad.Sci.USA, 111, 2014
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6NVO
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6PY9
 | | Crystal structure of red kidney bean purple acid phosphatase in complex with adenosine diphosphate metavanadate | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADP METAVANADATE, ... | | 著者 | Feder, D, Schenk, G, Guddat, L.W, McGeary, R.P, Mitic, N, Furtado, A, Schulz, B.L, Henry, R.J, Schmidt, S. | | 登録日 | 2019-07-29 | | 公開日 | 2020-04-29 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural elements that modulate the substrate specificity of plant purple acid phosphatases: Avenues for improved phosphorus acquisition in crops.
Plant Sci., 294, 2020
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1II7
 | | Crystal structure of P. furiosus Mre11 with manganese and dAMP | | 分子名称: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, Mre11 nuclease, ... | | 著者 | Hopfner, K.-P, Karcher, A, Craig, L, Woo, T.T, Carney, J.P, Tainer, J.A. | | 登録日 | 2001-04-20 | | 公開日 | 2001-05-30 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase.
Cell(Cambridge,Mass.), 105, 2001
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9ENG
 | | Structure of K.pneumoniae LpxH in complex with EBL-3218 | | 分子名称: | MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase, ~{N}-[4-[4-[3,5-bis(chloranyl)phenyl]piperazin-1-yl]sulfonylphenyl]-3-(methylsulfonylamino)benzamide | | 著者 | Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L. | | 登録日 | 2024-03-12 | | 公開日 | 2024-09-18 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors.
Eur.J.Med.Chem., 278, 2024
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2ZO9
 | | Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal ion preference | | 分子名称: | FE (II) ION, MALONATE ION, Phosphohydrolase | | 著者 | Jackson, C.J, Carr, P.D, Ollis, D.L. | | 登録日 | 2008-05-07 | | 公開日 | 2008-10-07 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference.
Acta Crystallogr.,Sect.F, 64, 2008
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6OFD
 | | The crystal structure of octadecyloxy(naphthalen-1-yl)methylphosphonic acid in complex with red kidney bean purple acid phosphatase | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Feder, D, Schenk, G, Guddat, L.W, Hussein, W.M, McGeary, R.P, Kan, M.W. | | 登録日 | 2019-03-29 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis.
Eur.J.Med.Chem., 182, 2019
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4H1S
 | | Crystal Structure of a Truncated Soluble form of Human CD73 with Ecto-5'-Nucleotidase activity | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-nucleotidase, PHOSPHATE ION, ... | | 著者 | Heuts, D.P, Weissenborn, M.J, Olkhov, R.V, Shaw, A.M, Levy, C.W, Scrutton, N.S. | | 登録日 | 2012-09-11 | | 公開日 | 2012-10-03 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of a soluble form of human CD73 with ecto-5'-nucleotidase activity.
Chembiochem, 13, 2012
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3HVQ
 | | Crystal structure of a complex between Protein Phosphatase 1 alpha (PP1) and the PP1 binding and PDZ domains of Neurabin | | 分子名称: | GLYCEROL, MANGANESE (II) ION, Neurabin-1, ... | | 著者 | Critton, D.A, Ragusa, M.J, Page, R, Peti, W. | | 登録日 | 2009-06-16 | | 公開日 | 2010-03-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites.
Nat.Struct.Mol.Biol., 17, 2010
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1QHW
 | | PURPLE ACID PHOSPHATASE FROM RAT BONE | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, PROTEIN (PURPLE ACID PHOSPHATASE), ... | | 著者 | Lindqvist, Y, Johansson, E, Kaija, H, Vihko, P, Schneider, G. | | 登録日 | 1999-03-26 | | 公開日 | 1999-09-15 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Three-dimensional structure of a mammalian purple acid phosphatase at 2.2 A resolution with a mu-(hydr)oxo bridged di-iron center.
J.Mol.Biol., 291, 1999
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2Q8U
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3DSD
 | | Crystal structure of P. furiosus Mre11-H85S bound to a branched DNA and manganese | | 分子名称: | DNA (5'-D(*DCP*DGP*DCP*DGP*DCP*DAP*DCP*DAP*DAP*DGP*DCP*DTP*DTP*DTP*DTP*DGP*DCP*DTP*DTP*DGP*DTP*DGP*DGP*DAP*DTP*DA)-3'), DNA double-strand break repair protein mre11, MANGANESE (II) ION | | 著者 | Williams, R.S, Moiani, D, Tainer, J.A. | | 登録日 | 2008-07-11 | | 公開日 | 2008-10-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
Cell(Cambridge,Mass.), 135, 2008
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2QFP
 | | Crystal structure of red kidney bean purple acid phosphatase in complex with fluoride | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, FLUORIDE ION, ... | | 著者 | Guddat, L.W, Schenk, G.S, Gahan, L.R, Elliot, T.W, Leung, E. | | 登録日 | 2007-06-27 | | 公開日 | 2008-10-14 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle.
Bmc Struct.Biol., 8, 2008
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4FBW
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2BQ8
 | | Crystal structure of human purple acid phosphatase with an inhibitory conformation of the repression loop | | 分子名称: | FE (II) ION, SULFATE ION, TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5, ... | | 著者 | Straeter, N, Jasper, B, Krebs, B. | | 登録日 | 2005-04-27 | | 公開日 | 2005-10-24 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal Structures of Recombinant Human Purple Acid Phosphatase with and without an Inhibitory Conformation of the Repression Loop.
J.Mol.Biol., 351, 2005
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7QGO
 | | Human CD73 (ecto 5'-nucleotidase) in complex with MRS4602 (a 3-methyl-CMPCP derivative, compound 21 in paper) in the closed state (crystal form III) | | 分子名称: | 5'-nucleotidase, ZINC ION, [[(2~{R},3~{S},4~{R},5~{R})-5-[(4~{E})-4-[(4-methoxycarbonylphenyl)methoxyimino]-3-methyl-2-oxidanylidene-pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid | | 著者 | Strater, N. | | 登録日 | 2021-12-09 | | 公開日 | 2022-02-16 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | | 主引用文献 | Structure-Activity Relationship of 3-Methylcytidine-5'-alpha , beta-methylenediphosphates as CD73 Inhibitors.
J.Med.Chem., 65, 2022
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6ALZ
 | | Crystal structure of Protein Phosphatase 1 bound to the natural inhibitor Tautomycetin | | 分子名称: | (2Z)-2-[(1R)-3-{[(2R,3S,4R,7S,8S,11S,13R,16E)-17-ethyl-4,8-dihydroxy-3,7,11,13-tetramethyl-6,15-dioxononadeca-16,18-dien-2-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | 著者 | Choy, M.S, Peti, W, Page, R. | | 登録日 | 2017-08-08 | | 公開日 | 2017-11-29 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.208 Å) | | 主引用文献 | PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors.
J. Am. Chem. Soc., 139, 2017
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2USH
 | | 5'-NUCLEOTIDASE FROM E. COLI | | 分子名称: | 5'-NUCLEOTIDASE, TUNGSTATE(VI)ION, ZINC ION | | 著者 | Knofel, T, Strater, N. | | 登録日 | 1998-09-24 | | 公開日 | 1999-06-15 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase containing a dimetal catalytic site.
Nat.Struct.Biol., 6, 1999
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