6GHM
| Structure of PP1 alpha phosphatase bound to ASPP2 | 分子名称: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Apoptosis-stimulating of p53 protein 2, ... | 著者 | Mouilleron, S, Bertran, T.M, Tapon, N, Zhou, Y. | 登録日 | 2018-05-08 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail. Nat Commun, 10, 2019
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5K77
| Dbr1 in complex with 7-mer branched RNA | 分子名称: | FE (II) ION, HYDROXIDE ION, RNA lariat debranching enzyme, ... | 著者 | Clark, N.E, Taylor, A.B, Hart, P.J. | 登録日 | 2016-05-25 | 公開日 | 2016-12-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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7TVF
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6Z9B
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7D0V
| Crystal structure of Taiwan cobra 5'-nucleotidase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Snake venom 5'-nucleotidase, ... | 著者 | Tsai, M.-H, Lin, I.-J, Lin, C.-C, Wu, W.-G. | 登録日 | 2020-09-12 | 公開日 | 2021-09-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.175 Å) | 主引用文献 | Crystal structure of Taiwan cobra 5'-nucleotidase To Be Published
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4UT3
| X-ray structure of the human PP1 gamma catalytic subunit treated with hydrogen peroxide | 分子名称: | MANGANESE (II) ION, PHOSPHATE ION, SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT | 著者 | Zeh Silva, M, Kopec, J, Fotinou, D, Steiner, R.A. | 登録日 | 2014-07-17 | 公開日 | 2015-07-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Targeted Redox Inhibition of Protein Phosphatase 1 by Nox4 Regulates Eif2Alpha-Mediated Stress Signaling. Embo J., 35, 2016
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4MOY
| Structure of a second nuclear PP1 Holoenzyme, crystal form 1 | 分子名称: | CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Choy, M.S, Hieke, M, Peti, W, Page, R. | 登録日 | 2013-09-12 | 公開日 | 2014-03-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1953 Å) | 主引用文献 | Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code. Proc.Natl.Acad.Sci.USA, 111, 2014
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6NVO
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4FBW
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2ZO9
| Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal ion preference | 分子名称: | FE (II) ION, MALONATE ION, Phosphohydrolase | 著者 | Jackson, C.J, Carr, P.D, Ollis, D.L. | 登録日 | 2008-05-07 | 公開日 | 2008-10-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference. Acta Crystallogr.,Sect.F, 64, 2008
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6PY9
| Crystal structure of red kidney bean purple acid phosphatase in complex with adenosine diphosphate metavanadate | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADP METAVANADATE, ... | 著者 | Feder, D, Schenk, G, Guddat, L.W, McGeary, R.P, Mitic, N, Furtado, A, Schulz, B.L, Henry, R.J, Schmidt, S. | 登録日 | 2019-07-29 | 公開日 | 2020-04-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural elements that modulate the substrate specificity of plant purple acid phosphatases: Avenues for improved phosphorus acquisition in crops. Plant Sci., 294, 2020
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6OFD
| The crystal structure of octadecyloxy(naphthalen-1-yl)methylphosphonic acid in complex with red kidney bean purple acid phosphatase | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Feder, D, Schenk, G, Guddat, L.W, Hussein, W.M, McGeary, R.P, Kan, M.W. | 登録日 | 2019-03-29 | 公開日 | 2019-09-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. Eur.J.Med.Chem., 182, 2019
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2BQ8
| Crystal structure of human purple acid phosphatase with an inhibitory conformation of the repression loop | 分子名称: | FE (II) ION, SULFATE ION, TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5, ... | 著者 | Straeter, N, Jasper, B, Krebs, B. | 登録日 | 2005-04-27 | 公開日 | 2005-10-24 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structures of Recombinant Human Purple Acid Phosphatase with and without an Inhibitory Conformation of the Repression Loop. J.Mol.Biol., 351, 2005
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4H1S
| Crystal Structure of a Truncated Soluble form of Human CD73 with Ecto-5'-Nucleotidase activity | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-nucleotidase, PHOSPHATE ION, ... | 著者 | Heuts, D.P, Weissenborn, M.J, Olkhov, R.V, Shaw, A.M, Levy, C.W, Scrutton, N.S. | 登録日 | 2012-09-11 | 公開日 | 2012-10-03 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of a soluble form of human CD73 with ecto-5'-nucleotidase activity. Chembiochem, 13, 2012
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1QHW
| PURPLE ACID PHOSPHATASE FROM RAT BONE | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, PROTEIN (PURPLE ACID PHOSPHATASE), ... | 著者 | Lindqvist, Y, Johansson, E, Kaija, H, Vihko, P, Schneider, G. | 登録日 | 1999-03-26 | 公開日 | 1999-09-15 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Three-dimensional structure of a mammalian purple acid phosphatase at 2.2 A resolution with a mu-(hydr)oxo bridged di-iron center. J.Mol.Biol., 291, 1999
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3DSD
| Crystal structure of P. furiosus Mre11-H85S bound to a branched DNA and manganese | 分子名称: | DNA (5'-D(*DCP*DGP*DCP*DGP*DCP*DAP*DCP*DAP*DAP*DGP*DCP*DTP*DTP*DTP*DTP*DGP*DCP*DTP*DTP*DGP*DTP*DGP*DGP*DAP*DTP*DA)-3'), DNA double-strand break repair protein mre11, MANGANESE (II) ION | 著者 | Williams, R.S, Moiani, D, Tainer, J.A. | 登録日 | 2008-07-11 | 公開日 | 2008-10-14 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell(Cambridge,Mass.), 135, 2008
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3HVQ
| Crystal structure of a complex between Protein Phosphatase 1 alpha (PP1) and the PP1 binding and PDZ domains of Neurabin | 分子名称: | GLYCEROL, MANGANESE (II) ION, Neurabin-1, ... | 著者 | Critton, D.A, Ragusa, M.J, Page, R, Peti, W. | 登録日 | 2009-06-16 | 公開日 | 2010-03-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites. Nat.Struct.Mol.Biol., 17, 2010
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1II7
| Crystal structure of P. furiosus Mre11 with manganese and dAMP | 分子名称: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, Mre11 nuclease, ... | 著者 | Hopfner, K.-P, Karcher, A, Craig, L, Woo, T.T, Carney, J.P, Tainer, J.A. | 登録日 | 2001-04-20 | 公開日 | 2001-05-30 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Cell(Cambridge,Mass.), 105, 2001
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2Q8U
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2QFP
| Crystal structure of red kidney bean purple acid phosphatase in complex with fluoride | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, FLUORIDE ION, ... | 著者 | Guddat, L.W, Schenk, G.S, Gahan, L.R, Elliot, T.W, Leung, E. | 登録日 | 2007-06-27 | 公開日 | 2008-10-14 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. Bmc Struct.Biol., 8, 2008
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7QGO
| Human CD73 (ecto 5'-nucleotidase) in complex with MRS4602 (a 3-methyl-CMPCP derivative, compound 21 in paper) in the closed state (crystal form III) | 分子名称: | 5'-nucleotidase, ZINC ION, [[(2~{R},3~{S},4~{R},5~{R})-5-[(4~{E})-4-[(4-methoxycarbonylphenyl)methoxyimino]-3-methyl-2-oxidanylidene-pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid | 著者 | Strater, N. | 登録日 | 2021-12-09 | 公開日 | 2022-02-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | 主引用文献 | Structure-Activity Relationship of 3-Methylcytidine-5'-alpha , beta-methylenediphosphates as CD73 Inhibitors. J.Med.Chem., 65, 2022
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6ALZ
| Crystal structure of Protein Phosphatase 1 bound to the natural inhibitor Tautomycetin | 分子名称: | (2Z)-2-[(1R)-3-{[(2R,3S,4R,7S,8S,11S,13R,16E)-17-ethyl-4,8-dihydroxy-3,7,11,13-tetramethyl-6,15-dioxononadeca-16,18-dien-2-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Choy, M.S, Peti, W, Page, R. | 登録日 | 2017-08-08 | 公開日 | 2017-11-29 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.208 Å) | 主引用文献 | PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors. J. Am. Chem. Soc., 139, 2017
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2USH
| 5'-NUCLEOTIDASE FROM E. COLI | 分子名称: | 5'-NUCLEOTIDASE, TUNGSTATE(VI)ION, ZINC ION | 著者 | Knofel, T, Strater, N. | 登録日 | 1998-09-24 | 公開日 | 1999-06-15 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase containing a dimetal catalytic site. Nat.Struct.Biol., 6, 1999
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1WAR
| Recombinant Human Purple Acid Phosphatase expressed in Pichia Pastoris | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, HUMAN PURPLE ACID PHOSPHATASE, ... | 著者 | Duff, A.P, Langley, D.B, Han, R, Averill, B.A, Freeman, H.C, Guss, J.M. | 登録日 | 2004-10-28 | 公開日 | 2005-07-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Crystal Structures of Recombinant Human Purple Acid Phosphatase with and without an Inhibitory Conformation of the Repression Loop. J.Mol.Biol., 351, 2005
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4WWL
| E. coli 5'-nucleotidase mutant I521C labeled with MTSL (intermediate form) | 分子名称: | CARBONATE ION, GLYCEROL, Protein UshA, ... | 著者 | Krug, U, Paithankar, K.S, Schultz-Heienbrok, R, Strater, N. | 登録日 | 2014-11-11 | 公開日 | 2014-11-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | E. coli 5'-nucleotidase mutant I521C labeled with MTSL (intermediate form) To Be Published
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