9ENG

Structure of K.pneumoniae LpxH in complex with EBL-3218

This is a non-PDB format compatible entry.

Summary for 9ENG

• Entry DOI: 10.2210/pdb9eng/pdb
• Descriptor: UDP-2,3-diacylglucosamine hydrolase, MANGANESE (II) ION, ~{N}-[4-[4-[3,5-bis(chloranyl)phenyl]piperazin-1-yl]sulfonylphenyl]-3-(methylsulfonylamino)benzamide, ... (4 entities in total)
• Functional Keywords: lipid a biosynthesis pathway endotoxin udp-diacyl-glucosamine lipid x gram-negative bacteria antibiotic lipopolysaccharides, hydrolase
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 28702.33

Authors

Sooriyaarachchi, S.,Bergfors, T.,Jones, T.A.,Mowbray, S.L. (deposition date: 2024-03-12, release date: 2024-09-18)

• Primary citation: Benediktsdottir, A.,Sooriyaarachchi, S.,Cao, S.,Ottosson, N.E.,Lindstrom, S.,Lundgren, B.,Kloditz, K.,Lola, D.,Bobileva, O.,Loza, E.,Hughes, D.,Jones, T.A.,Mowbray, S.L.,Zamaratski, E.,Sandstrom, A.,Karlen, A.; Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors.; Eur.J.Med.Chem., 278:116790-116790, 2024; PubMed: 39236497; DOI: 10.1016/j.ejmech.2024.116790

Experimental method

X-RAY DIFFRACTION (2.2 Å)