7KS3
| GluK2/K5 with L-Glu | 分子名称: | Glutamate receptor ionotropic, kainate 2, kainate 5,Green fluorescent protein chimera | 著者 | Khanra, N, Brown, P.M.G.E, Perozzo, A.M, Bowie, D, Meyerson, J.R. | 登録日 | 2020-11-20 | 公開日 | 2021-03-24 | 最終更新日 | 2021-07-07 | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | 主引用文献 | Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor. Elife, 10, 2021
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5CBR
| Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid at 2.0A resolution | 分子名称: | 3,4-dichloro-5-(5-hydroxypyridin-3-yl)-L-phenylalanine, ACETATE ION, GLYCEROL, ... | 著者 | Frydenvang, K, Kastrup, J.S. | 登録日 | 2015-07-01 | 公開日 | 2015-12-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.996 Å) | 主引用文献 | Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. J.Med.Chem., 59, 2016
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6FQH
| GluA2(flop) S729C ligand binding core dimer bound to NBQX at 1.76 Angstrom resolution | 分子名称: | 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 2,Glutamate receptor 2 | 著者 | Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G. | 登録日 | 2018-02-14 | 公開日 | 2019-03-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75940013 Å) | 主引用文献 | Homomeric GluA2(R) AMPA receptors can conduct when desensitized. Nat Commun, 10, 2019
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5CC2
| STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE IONOTROPIC GLUTAMATE RECEPTOR-LIKE GLUD2 IN COMPLEX WITH 7-CKA | 分子名称: | 7-Chlorokynurenic acid, CHLORIDE ION, GLYCEROL, ... | 著者 | Naur, P, Gajhede, M, Kastrup, J.S. | 登録日 | 2015-07-01 | 公開日 | 2015-12-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors. Mol.Pharmacol., 89, 2016
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3LSW
| Aniracetam bound to the ligand binding domain of GluA3 | 分子名称: | 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE, GLUTAMIC ACID, GluA2 S1S2 domain, ... | 著者 | Ahmed, A.H, Oswald, R.E. | 登録日 | 2010-02-13 | 公開日 | 2010-03-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.752 Å) | 主引用文献 | Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors. J.Med.Chem., 53, 2010
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7QHH
| Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD) | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, GLUTAMIC ACID, ... | 著者 | Herguedas, B, Kohegyi, B, Dohrke, J.N, Watson, J.F, Zhang, D, Ho, H, Shaikh, S, Lape, R, Krieger, J.M, Greger, I.H. | 登録日 | 2021-12-12 | 公開日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
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5CBS
| Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid at 1.8A resolution | 分子名称: | (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Frydenvang, K, Kastrup, J.S. | 登録日 | 2015-07-01 | 公開日 | 2015-12-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. J.Med.Chem., 59, 2016
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7QHB
| Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, CYCLOTHIAZIDE, ... | 著者 | Herguedas, B, Kohegyi, B, Zhang, D, Greger, I.H. | 登録日 | 2021-12-11 | 公開日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
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5CMM
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5CMK
| Crystal structure of the GluK2EM LBD dimer assembly complex with glutamate and LY466195 | 分子名称: | (3S,4aR,6S,8aR)-6-{[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl}decahydroisoquinoline-3-carboxylic acid, CHLORIDE ION, GLUTAMIC ACID, ... | 著者 | Chittori, S, Mayer, M.L. | 登録日 | 2015-07-16 | 公開日 | 2016-07-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Structural basis of kainate subtype glutamate receptor desensitization. Nature, 537, 2016
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7LZI
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7LZH
| Structure of the glutamate receptor-like channel AtGLR3.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | 著者 | Gangwar, S.P, Green, M.N, Sobolevsky, A.I. | 登録日 | 2021-03-09 | 公開日 | 2021-07-28 | 最終更新日 | 2021-08-18 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4. Mol.Cell, 81, 2021
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7LZ2
| Structure of glutamate receptor-like channel GLR3.4 ligand-binding domain in complex with methionine | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, GLYCEROL, ... | 著者 | Gangwar, S.P, Green, M.N, Sobolevsky, A.I. | 登録日 | 2021-03-08 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4. Mol.Cell, 81, 2021
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7LZ0
| Structure of glutamate receptor-like channel GLR3.4 ligand-binding domain in complex with glutamate | 分子名称: | CHLORIDE ION, GLUTAMIC ACID, GLYCEROL, ... | 著者 | Gangwar, S.P, Green, M.N, Sobolevsky, A.I. | 登録日 | 2021-03-08 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4. Mol.Cell, 81, 2021
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7LZ1
| Structure of glutamate receptor-like channel GLR3.4 ligand-binding domain in complex with serine | 分子名称: | GLYCEROL, Glutamate receptor 3.4, SERINE, ... | 著者 | Gangwar, S.P, Green, M.N, Sobolevsky, A.I. | 登録日 | 2021-03-08 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4. Mol.Cell, 81, 2021
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6GIV
| Structure of GluA2-N775S ligand-binding domain (S1S2J) in complex with glutamate and Rubidium Bromide at 1.75 A resolution | 分子名称: | BROMIDE ION, GLUTAMIC ACID, GLYCEROL, ... | 著者 | Venskutonyte, R, Frydenvang, K, Kastrup, J.S. | 登録日 | 2018-05-15 | 公開日 | 2019-05-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors. Neuron, 102, 2019
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5DEX
| Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, phenyl-ACEPC | 分子名称: | 5-[(2R)-2-amino-2-carboxyethyl]-1-phenyl-1H-pyrazole-3-carboxylic acid, GLYCINE, Glutamate receptor ionotropic, ... | 著者 | Mou, T.-C, Conti, P, Pinto, A, Tamborini, L, Sprang, S.R, Hansen, K.B. | 登録日 | 2015-08-26 | 公開日 | 2016-09-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits. Proc. Natl. Acad. Sci. U.S.A., 2017
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8AYO
| Open state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one, ... | 著者 | Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H. | 登録日 | 2022-09-02 | 公開日 | 2023-04-19 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics. Nat Commun, 14, 2023
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8AYM
| Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol, ... | 著者 | Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H. | 登録日 | 2022-09-02 | 公開日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics. Nat Commun, 14, 2023
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3LSX
| Piracetam bound to the ligand binding domain of GluA3 | 分子名称: | 2-(2-oxopyrrolidin-1-yl)acetamide, GLUTAMIC ACID, GluA3 S1S2 domain, ... | 著者 | Ahmed, A.H, Oswald, R.E. | 登録日 | 2010-02-13 | 公開日 | 2011-03-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.006 Å) | 主引用文献 | Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors. J.Med.Chem., 53, 2010
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6HCB
| STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.9 A RESOLUTION. | 分子名称: | 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide), CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Laulumaa, S, Masternak, M, Frydenvang, K, Kastrup, J.S. | 登録日 | 2018-08-14 | 公開日 | 2019-04-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. Acs Med.Chem.Lett., 10, 2019
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6HCA
| STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S1J) IN COMPLEX WITH POSITIVE ALLOSTERIC MODULATOR TDPAM02 AT 1.8 A RESOLUTION | 分子名称: | 6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE), CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Laulumaa, S, Hansen, K.V, Frydenvang, K, Kastrup, J.S. | 登録日 | 2018-08-14 | 公開日 | 2019-04-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.882 Å) | 主引用文献 | Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. Acs Med.Chem.Lett., 10, 2019
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3LSF
| Piracetam bound to the ligand binding domain of GluA2 | 分子名称: | 2-(2-oxopyrrolidin-1-yl)acetamide, GLUTAMIC ACID, Glutamate receptor 2, ... | 著者 | Ahmed, A.H, Ptak, C.P, Oswald, R.E. | 登録日 | 2010-02-12 | 公開日 | 2010-03-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | 主引用文献 | Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors. J.Med.Chem., 53, 2010
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3LSL
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6HCH
| STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.6 A RESOLUTION. | 分子名称: | 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide), ACETATE ION, CHLORIDE ION, ... | 著者 | Laulumaa, S, Hansen, K.V, Frydenvang, K, Kastrup, J.S. | 登録日 | 2018-08-15 | 公開日 | 2019-04-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. Acs Med.Chem.Lett., 10, 2019
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