8SS4

Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 (apo state)

Summary for 8SS4

Entry DOI	10.2210/pdb8ss4/pdb
EMDB information	40743
Descriptor	Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera, Protein cornichon homolog 2, SPERMIDINE (3 entities in total)
Functional Keywords	ampa receptor, neurotransmission, tarp gamma-5, cornichon-2, signaling protein
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	6
Total formula weight	497957.52
Authors	Yen, L.Y.,Gangwar, S.P.,Yelshanskaya, M.V.,Sobolevsky, A.I. (deposition date: 2023-05-08, release date: 2023-09-06, Last modification date: 2023-11-01)
Primary citation	Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Korman, A.,Jones, D.R.,Sobolevsky, A.I. Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30:1481-1494, 2023 Cited by PubMed: 37653241 DOI: 10.1038/s41594-023-01080-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation