8SS8

Structure of AMPA receptor GluA2 complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state)

Summary for 8SS8

Entry DOI	10.2210/pdb8ss8/pdb
EMDB information	40741 40742 40743 40744 40745 40746 40747 40748 40749 40750
Descriptor	Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera, 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid, ... (7 entities in total)
Functional Keywords	ampa receptor, neurotransmission, tarp gamma-5, perampanel, signaling protein
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	4
Total formula weight	474788.97
Authors	Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Sobolevsky, A.I. (deposition date: 2023-05-08, release date: 2023-09-06, Last modification date: 2023-10-25)
Primary citation	Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Korman, A.,Jones, D.R.,Sobolevsky, A.I. Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30:1481-1494, 2023 Cited by PubMed: 37653241 DOI: 10.1038/s41594-023-01080-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.81 Å)

Structure validation