8SSB

Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to glutamate and channel blocker spermidine (desensitized state)

Summary for 8SSB

Entry DOI	10.2210/pdb8ssb/pdb
EMDB information	40741 40742 40743 40744 40745 40746 40747 40748 40749 40750
Descriptor	Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera, Protein cornichon homolog 2, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (5 entities in total)
Functional Keywords	ampa receptor, spermidine, tarp gamma-5, cornichon-2, signaling protein
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	6
Total formula weight	520585.43
Authors	Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Sobolevsky, A.I. (deposition date: 2023-05-08, release date: 2023-09-06, Last modification date: 2023-10-25)
Primary citation	Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Korman, A.,Jones, D.R.,Sobolevsky, A.I. Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30:1481-1494, 2023 Cited by PubMed: 37653241 DOI: 10.1038/s41594-023-01080-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.66 Å)

Structure validation