8OOT
 
 | | CryoEM Structure INO80core Hexasome complex Arp5 Ies6 refinement state2 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling complex subunit IES6, ... | | 著者 | Zhang, M, Jungblut, A, Hoffmann, T, Eustermann, S. | | 登録日 | 2023-04-05 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling.
Science, 381, 2023
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4JIT
 | | Crystal Structure of E. coli XGPRT in complex with (S)-3-(Guanin-9-yl)pyrrolidin-N-ylacetylphosphonic acid | | 分子名称: | Xanthine phosphoribosyltransferase, {2-[(3S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)pyrrolidin-1-yl]-2-oxoethyl}phosphonic acid | | 著者 | Keough, D.T, Hockova, D, Rejman, D, Spacek, P, Vrbkova, S, Krecmerova, M, Eng, W.S, Jans, H, West, N.P, Naesens, L.M.J, de Jersey, J, Guddat, L.W. | | 登録日 | 2013-03-07 | | 公開日 | 2014-12-24 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.
J.Med.Chem., 56, 2013
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5EIF
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5EHG
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8OOC
 | | CryoEM Structure INO80core Hexasome complex Rvb core refinement state1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Chromatin-remodeling ATPase Ino80, ... | | 著者 | Zhang, M, Jungblut, A, Hoffmann, T, Eustermann, S. | | 登録日 | 2023-04-05 | | 公開日 | 2023-08-02 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling.
Science, 381, 2023
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8OOF
 | | CryoEM Structure INO80core Hexasome complex Arp5 Ies6 refinement state1 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling complex subunit IES6, ... | | 著者 | Zhang, M, Jungblut, A, Hoffmann, T, Eustermann, S. | | 登録日 | 2023-04-05 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling.
Science, 381, 2023
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5E9Q
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5ETJ
 | | Crystal structure of purine nucleoside phosphorylase (E258D, L261A) mutant from human complexed with DADMe-ImmG and phosphate | | 分子名称: | 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase | | 著者 | Cameron, S.A, Suarez, J, Schramm, V.L, Almo, S.C. | | 登録日 | 2015-11-17 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics.
J.Am.Chem.Soc., 138, 2016
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5EIW
 | | DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT NB3C2 | | 分子名称: | 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE, NS5 methyltransferase, S-ADENOSYLMETHIONINE | | 著者 | Barral, K, Bricogne, G, Sharff, A. | | 登録日 | 2015-10-30 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.611 Å) | | 主引用文献 | Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Eur.J.Med.Chem., 125, 2016
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5LOD
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3VQS
 | | Crystal structure of HCV NS5B RNA polymerase with a novel piperazine inhibitor | | 分子名称: | (2R)-4-(5-cyclopropyl[1,3]thiazolo[4,5-d]pyrimidin-2-yl)-N-[3-fluoro-4-(trifluoromethoxy)benzyl]-1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine-2-carboxamide, CHLORIDE ION, RNA-directed RNA polymerase | | 著者 | Adachi, T, Doi, S, Ando, I, Sugimoto, K, Orita, T, Nomura, A, Kamada, M. | | 登録日 | 2012-03-30 | | 公開日 | 2012-08-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase.
Antimicrob.Agents Chemother., 56, 2012
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2NQB
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2KHZ
 | | Solution Structure of RCL | | 分子名称: | c-Myc-responsive protein Rcl | | 著者 | Doddapaneni, K, Mahler, B, Yuan, C, Wu, Z. | | 登録日 | 2009-04-15 | | 公開日 | 2009-10-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of RCL, a novel 2'-deoxyribonucleoside 5'-monophosphate N-glycosidase
J.Mol.Biol., 394, 2009
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6EVS
 | | Characterization of 2-deoxyribosyltransferase from psychrotolerant bacterium Bacillus psychrosaccharolyticus: a suitable biocatalyst for the industrial synthesis of antiviral and antitumoral nucleosides | | 分子名称: | N-deoxyribosyltransferase | | 著者 | Fresco-Tabohada, A, Fernandez-Lucas, J, Acebal, C, Arroyo, M, Ramon, F, Mancheno, J.M, de la Mata, I. | | 登録日 | 2017-11-02 | | 公開日 | 2018-11-14 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | 2'-Deoxyribosyltransferase from Bacillus psychrosaccharolyticus: A Mesophilic-Like Biocatalyst for the Synthesis of Modified Nucleosides from a Psychrotolerant Bacterium
Catalysts, 2019
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8GVC
 | | The cryo-EM structure of hAE2 with bicarbonate | | 分子名称: | Anion exchange protein 2, BICARBONATE ION | | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | | 登録日 | 2022-09-14 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.
Nat Commun, 14, 2023
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8GVF
 | | The outward-facing structure of hAE2 in basic pH | | 分子名称: | Anion exchange protein 2 | | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | | 登録日 | 2022-09-15 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.
Nat Commun, 14, 2023
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8GVH
 | | Human AE2 in acidic KNO3 | | 分子名称: | Anion exchange protein 2, CHOLESTEROL HEMISUCCINATE | | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | | 登録日 | 2022-09-15 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.
Nat Commun, 14, 2023
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8GV9
 | | The cryo-EM structure of hAE2 with chloride ion | | 分子名称: | Anion exchange protein 2, CHLORIDE ION | | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | | 登録日 | 2022-09-14 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.
Nat Commun, 14, 2023
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8GV8
 | | The cryo-EM structure of hAE2 with DIDS | | 分子名称: | 2,2'-ethane-1,2-diylbis{5-[(sulfanylmethyl)amino]benzenesulfonic acid}, Anion exchange protein 2 | | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | | 登録日 | 2022-09-14 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.
Nat Commun, 14, 2023
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8GVA
 | | The intermediate structure of hAE2 in basic pH | | 分子名称: | Anion exchange protein 2 | | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | | 登録日 | 2022-09-14 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.
Nat Commun, 14, 2023
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8GVE
 | | The asymmetry structure of hAE2 | | 分子名称: | Anion exchange protein 2 | | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | | 登録日 | 2022-09-15 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.
Nat Commun, 14, 2023
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5M5P
 | | S. cerevisiae spliceosomal helicase Brr2 (271-end) in complex with the Jab/MPN domain of S. cerevisiae Prp8 | | 分子名称: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2 | | 著者 | Becke, C, Absmeier, E, Wollenhaupt, J, Santos, K.F, Wahl, M.C. | | 登録日 | 2016-10-22 | | 公開日 | 2016-12-07 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | | 主引用文献 | Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.
Cell Cycle, 16, 2017
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3CSO
 | | HCV Polymerase in complex with a 1,5 Benzodiazepine inhibitor | | 分子名称: | (11S)-10-acetyl-11-[4-(benzyloxy)-3-chlorophenyl]-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one, RNA-directed RNA polymerase | | 著者 | Nyanguile, O. | | 登録日 | 2008-04-10 | | 公開日 | 2009-04-14 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.
Antimicrob.Agents Chemother., 52, 2008
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7SEK
 | | Solution structure of the zinc finger domain of murine MetAP1, complexed with ZNG N-terminal peptide | | 分子名称: | COBW domain-containing protein 1,Methionine aminopeptidase 1 fusion, ZINC ION | | 著者 | Edmonds, K.A, Jordan, M.R, Thalluri, K, Wu, H, Di Marchi, R, Giedroc, D.P. | | 登録日 | 2021-09-30 | | 公開日 | 2022-06-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis.
Cell, 185, 2022
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5MFY
 | | RBM5 OCRE domain | | 分子名称: | RNA-binding protein 5 | | 著者 | Warner, L.R, Mourao, A, Soni, K, Sattler, M. | | 登録日 | 2016-11-19 | | 公開日 | 2016-12-07 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for the recognition of spliceosomal SmN/B/B' proteins by the RBM5 OCRE domain in splicing regulation.
Elife, 5, 2016
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