PDB: 2832 件ウェブページステータス検索Chemie searchBIRD

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1H3E	Tyrosyl-tRNA synthetase from Thermus thermophilus complexed with wild-type tRNAtyr(GUA) and with ATP and tyrosinol 分子名称: 4-[(2S)-2-amino-3-hydroxypropyl]phenol, ADENOSINE-5'-TRIPHOSPHATE, TYROSYL-TRNA SYNTHETASE, ... 著者 Cusack, S, Yaremchuk, A, Kriklivyi, I, Tukalo, M. 登録日 2002-08-28 公開日 2002-10-27 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Class I Tyrosyl-tRNA Synthetase Has a Class II Mode or tRNA Recognition Embo J., 21, 2002
5MC6	Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... 著者 Schmidt, C, Kowalinski, E, Shanmuganathan, V, Defenouillere, Q, Braunger, K, Heuer, A, Pech, M, Namane, A, Berninghausen, O, Fromont-Racine, M, Jacquier, A, Conti, E, Becker, T, Beckmann, R. 登録日 2016-11-09 公開日 2017-01-18 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex. Science, 354, 2016
3HCU	Crystal structure of TRAF6 in complex with Ubc13 in the C2 space group 分子名称: TNF receptor-associated factor 6, Ubiquitin-conjugating enzyme E2 N, ZINC ION 著者 Yin, Q, Lin, S.-C, Lamothe, B, Lu, M, Lo, Y.-C, Hura, G, Zheng, L, Rich, R.L, Campos, A.D, Myszka, D.G, Lenardo, M.J, Darnay, B.G, Wu, H. 登録日 2009-05-06 公開日 2009-05-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 E2 interaction and dimerization in the crystal structure of TRAF6. Nat.Struct.Mol.Biol., 16, 2009
5NDG	Crystal structure of geneticin (G418) bound to the yeast 80S ribosome 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... 著者 Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. 登録日 2017-03-08 公開日 2017-12-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3OJ4	Crystal structure of the A20 ZnF4, ubiquitin and UbcH5A complex 分子名称: Tumor necrosis factor alpha-induced protein 3, Ubiquitin, Ubiquitin-conjugating enzyme E2 D1, ... 著者 Bosanac, I, Hymowitz, S.G. 登録日 2010-08-20 公開日 2010-12-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling Mol.Cell, 40, 2010
1NYR	Structure of Staphylococcus aureus threonyl-tRNA synthetase complexed with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, THREONINE, ZINC ION, ... 著者 Torres-Larios, A, Sankaranarayanan, R, Rees, B, Dock-Bregeon, A.C, Moras, D. 登録日 2003-02-13 公開日 2003-10-28 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Conformational movements and cooperativity upon amino acid, ATP and tRNA binding in threonyl-tRNA synthetase J.Mol.Biol., 331, 2003
1NYQ	Structure of Staphylococcus aureus threonyl-tRNA synthetase complexed with an analogue of threonyl adenylate 分子名称: 5'-O-(N-(L-THREONYL)-SULFAMOYL)ADENOSINE, ZINC ION, threonyl-tRNA synthetase 1 著者 Torres-Larios, A, Sankaranarayanan, R, Rees, B, Dock-Bregeon, A.C, Moras, D. 登録日 2003-02-13 公開日 2003-10-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Conformational movements and cooperativity upon amino acid, ATP and tRNA binding in threonyl-tRNA synthetase J.Mol.Biol., 331, 2003
2DR2	Structure of human tryptophanyl-tRNA synthetase in complex with tRNA(Trp) 分子名称: SULFATE ION, TRYPTOPHAN, Tryptophanyl-tRNA synthetase, ... 著者 Shen, N, Guo, L, Yang, B, Jin, Y, Ding, J. 登録日 2006-06-05 公開日 2006-07-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of human tryptophanyl-tRNA synthetase in complex with tRNA(Trp) reveals the molecular basis of tRNA recognition and specificity Nucleic Acids Res., 34, 2006
6K1S	Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors 分子名称: 1,2-ETHANEDIOL, 2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethanal, DIMETHYL SULFOXIDE, ... 著者 Tong, S, Lin, H. 登録日 2019-05-12 公開日 2019-06-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors. Acs Med.Chem.Lett., 10, 2019
7QXW	Proteasome-ZFAND5 Complex Z+D state 分子名称: 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, ... 著者 Zhu, Y, Lu, Y. 登録日 2022-01-27 公開日 2023-02-08 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
6P4H	Structure of a mammalian small ribosomal subunit in complex with the Israeli Acute Paralysis Virus IRES (Class 2) 分子名称: 18S rRNA, IAPV-IRES, RACK1, ... 著者 Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. 登録日 2019-05-27 公開日 2019-09-18 最終更新日 2020-01-08 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
6P4G	Structure of a mammalian small ribosomal subunit in complex with the Israeli Acute Paralysis Virus IRES (Class 1) 分子名称: 18S rRNA, IAPV-IRES, RACK1, ... 著者 Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. 登録日 2019-05-27 公開日 2019-09-18 最終更新日 2020-01-08 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
6FTI	Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Programmed 80S Ribosome 分子名称: 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... 著者 Braunger, K, Becker, T, Beckmann, R. 登録日 2018-02-22 公開日 2018-03-21 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum. Science, 360, 2018
7ZV2	HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... 著者 Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. 登録日 2022-05-13 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
7ZVL	HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, GLYCEROL, ... 著者 Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. 登録日 2022-05-16 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
7ZUU	HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... 著者 Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. 登録日 2022-05-13 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
7ZUQ	HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... 著者 Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. 登録日 2022-05-13 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
7ZUP	Human PRMT5:MEP50 structure with Fragment (Example 18) and MTA Bound 分子名称: 3-ethylimidazo[4,5-b]pyridin-2-amine, 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, ... 著者 Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. 登録日 2022-05-12 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
7ZUY	HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... 著者 Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. 登録日 2022-05-13 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
7ZVU	HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... 著者 Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. 登録日 2022-05-17 公開日 2022-10-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
2YXN	Structual basis of azido-tyrosine recognition by engineered bacterial Tyrosyl-tRNA synthetase 分子名称: 3-AZIDO-L-TYROSINE, Tyrosyl-tRNA synthetase 著者 Oki, K, Kobayashi, T, Sakamoto, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-04-26 公開日 2008-04-29 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Functional replacement of the endogenous tyrosyl-tRNA synthetase-tRNATyr pair by the archaeal tyrosine pair in Escherichia coli for genetic code expansion Nucleic Acids Res., 38, 2010
4RJ9	Structure of a plant specific C2 domain protein, OsGAP1 from rice 分子名称: C2 domain-containing protein-like, POTASSIUM ION 著者 Miao, R, Fong, Y.H, Wong, K.B, Lam, H.M. 登録日 2014-10-08 公開日 2015-08-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Site-directed Mutagenesis Shows the Significance of Interactions with Phospholipids and the G-protein OsYchF1 for the Physiological Functions of the Rice GTPase-activating Protein 1 (OsGAP1). J.Biol.Chem., 290, 2015
7TM3	Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon 分子名称: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... 著者 Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. 登録日 2022-01-19 公開日 2022-10-19 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.25 Å) 主引用文献 Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022
7TUT	Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in complex with the multipass translocon 分子名称: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... 著者 Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. 登録日 2022-02-03 公開日 2022-10-19 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.88 Å) 主引用文献 Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022
5B7A	SOLUTION STRUCTURE OF LYS37 ACETYLATED HUMAN SUMO1 分子名称: Small ubiquitin-related modifier 1 著者 Naik, M.T, Naik, N, Shih, H, Huang, T. 登録日 2016-06-05 公開日 2017-06-07 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 Structures Of Human Sumo To Be Published

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