7N6O
 
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4W8N
 | | The crystal structure of hemagglutinin from a swine influenza virus (A/swine/Missouri/2124514/2006) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | | 著者 | Yang, H, Carney, P.J, Tumpey, T.M, Stevens, J. | | 登録日 | 2014-08-25 | | 公開日 | 2015-02-11 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Assessment of transmission, pathogenesis and adaptation of H2 subtype influenza viruses in ferrets.
Virology, 477C, 2015
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3JUH
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4W9F
 | | pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 5) | | 分子名称: | (4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | | 著者 | van Molle, I, Hewitt, S, Galdeano, C, Gadd, M.S, Ciulli, A. | | 登録日 | 2014-08-27 | | 公開日 | 2014-09-10 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
J.Med.Chem., 57, 2014
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4WBV
 | | Crystal structure of a prion peptide | | 分子名称: | PrP peptide | | 著者 | Yu, L, Lee, S.-J, Yee, V. | | 登録日 | 2014-09-03 | | 公開日 | 2015-05-27 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations.
Biochemistry, 54, 2015
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4V4A
 | | Crystal Structure of the Wild Type Ribosome from E. Coli 70S Ribosome. | | 分子名称: | 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S ribosomal protein S10, ... | | 著者 | Vila-Sanjurjo, A, Ridgeway, W.K, Seymaner, V, Zhang, W, Santoso, S, Yu, K, Cate, J.H.D. | | 登録日 | 2003-06-13 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (9.5 Å) | | 主引用文献 | X-ray crystal structures of the WT and a hyper-accurate ribosome from Escherichia coli
Proc.Natl.Acad.Sci.USA, 100, 2003
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4V4T
 | | Crystal structure of the whole ribosomal complex with a stop codon in the A-site. | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Petry, S, Brodersen, D.E, Murphy IV, F.V, Dunham, C.M, Selmer, M, Tarry, M.J, Kelley, A.C, Ramakrishnan, V. | | 登録日 | 2005-10-12 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-12-25 | | 実験手法 | X-RAY DIFFRACTION (6.46 Å) | | 主引用文献 | Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon.
Cell(Cambridge,Mass.), 123, 2005
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3JQB
 | | Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (DX6) | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Tulloch, L.B, Hunter, W.N. | | 登録日 | 2009-09-06 | | 公開日 | 2009-12-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
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4UTH
 | | XenA - oxidized - Y183F variant | | 分子名称: | FLAVIN MONONUCLEOTIDE, NADH:flavin oxidoreductase, SULFATE ION | | 著者 | Werther, T, Dobbek, H. | | 登録日 | 2014-07-21 | | 公開日 | 2015-08-05 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase
Nat Commun, 8, 2017
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3K42
 | | Crystal structure of sCD-MPR mutant E19Q/K137M pH 7.0 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-dependent mannose-6-phosphate receptor, SN-GLYCEROL-1-PHOSPHATE, ... | | 著者 | Olson, L.J, Sun, G, Bohnsack, R.N, Peterson, F.C, Dahms, N.M, Kim, J.J.P. | | 登録日 | 2009-10-05 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor.
Biochemistry, 49, 2010
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4V5K
 | | Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... | | 著者 | Ng, C.L, Lang, K, Meenan, N.A.G, Sharma, A, Kelley, A.C, Kleanthous, C, Ramakrishnan, V. | | 登録日 | 2010-05-29 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural Basis for 16S Ribosomal RNA Cleavage by the Cytotoxic Domain of Colicin E3.
Nat.Struct.Mol.Biol., 17, 2010
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4V69
 | | Ternary complex-bound E.coli 70S ribosome. | | 分子名称: | 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Villa, E, Sengupta, J, Trabuco, L.G, LeBarron, J, Baxter, W.T, Shaikh, T.R, Grassucci, R.A, Nissen, P, Ehrenberg, M, Schulten, K, Frank, J. | | 登録日 | 2008-12-11 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (6.7 Å) | | 主引用文献 | Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis
Proc.Natl.Acad.Sci.USA, 106, 2009
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4V6O
 | | Structural characterization of mRNA-tRNA translocation intermediates (class 4a of the six classes) | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Agirrezabala, X, Liao, H, Schreiner, E, Fu, J, Ortiz-Meoz, R.F, Schulten, K, Green, R, Frank, J. | | 登録日 | 2011-12-07 | | 公開日 | 2014-07-09 | | 最終更新日 | 2025-03-19 | | 実験手法 | ELECTRON MICROSCOPY (14.7 Å) | | 主引用文献 | Structural characterization of mRNA-tRNA translocation intermediates.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4V70
 | | E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre3) | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Blau, C, Bock, L.V, Schroder, G.F, Davydov, I, Fischer, N, Stark, H, Rodnina, M.V, Vaiana, A.C, Grubmuller, H. | | 登録日 | 2013-10-14 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (17 Å) | | 主引用文献 | Energy barriers and driving forces in tRNA translocation through the ribosome.
Nat.Struct.Mol.Biol., 20, 2013
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4V7E
 | | Model of the small subunit RNA based on a 5.5 A cryo-EM map of Triticum aestivum translating 80S ribosome | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S10E, ... | | 著者 | Barrio-Garcia, C, Armache, J.-P, Jarasch, A, Anger, A.M, Villa, E, Becker, T, Bhushan, S, Jossinet, F, Habeck, M, Dindar, G, Franckenberg, S, Marquez, V, Mielke, T, Thomm, M, Berninghausen, O, Beatrix, B, Soeding, J, Westhof, E, Wilson, D.N, Beckmann, R. | | 登録日 | 2013-11-22 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | | 主引用文献 | Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion.
Nature, 506, 2014
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4V7Z
 | | Structure of the Thermus thermophilus 70S ribosome complexed with telithromycin. | | 分子名称: | 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A. | | 登録日 | 2010-08-18 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
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4V8X
 | | Structure of Thermus thermophilus ribosome | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... | | 著者 | Feng, S, Chen, Y, Kamada, K, Wang, H, Tang, K, Wang, M, Gao, Y.G. | | 登録日 | 2013-07-19 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | | 主引用文献 | Yoeb-Ribosome Structure: A Canonical Rnase that Requires the Ribosome for its Specific Activity.
Nucleic Acids Res., 41, 2013
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4V9L
 | | 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state. | | 分子名称: | 23S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Zhou, J, Lancaster, L, Donohue, J.P, Noller, H.F. | | 登録日 | 2013-04-24 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation.
Science, 340, 2013
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7NFD
 | | Structure of mitoxantrone-bound ABCG2 | | 分子名称: | 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, ... | | 著者 | Kowal, J, Locher, K, Ni, D, Stahlberg, H. | | 登録日 | 2021-02-06 | | 公開日 | 2021-04-21 | | 最終更新日 | 2025-07-09 | | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | | 主引用文献 | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2.
J.Mol.Biol., 433, 2021
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4WF6
 | | Anthrax toxin lethal factor with bound small molecule inhibitor MK-31 | | 分子名称: | 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ... | | 著者 | Maize, K.M, De la Mora-Rey, T, Finzel, B.C. | | 登録日 | 2014-09-12 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.6521 Å) | | 主引用文献 | Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
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4WG5
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4WG3
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4WHB
 | | Crystal structure of phenylurea hydrolase B | | 分子名称: | Phenylurea hydrolase B, ZINC ION | | 著者 | Sugrue, E, Carr, P.D, Khurana, J.L, Jackson, C.J. | | 登録日 | 2014-09-21 | | 公開日 | 2015-02-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.958 Å) | | 主引用文献 | Evolutionary Expansion of the Amidohydrolase Superfamily in Bacteria in Response to the Synthetic Compounds Molinate and Diuron.
Appl.Environ.Microbiol., 81, 2015
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7NT9
 | | Trimeric SARS-CoV-2 spike ectodomain in complex with biliverdin (closed conformation) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ... | | 著者 | Rosa, A, Pye, V.E, Nans, A, Cherepanov, P. | | 登録日 | 2021-03-09 | | 公開日 | 2021-04-28 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity.
Sci Adv, 7, 2021
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4WIB
 | | Crystal structure of Magnesium transporter MgtE | | 分子名称: | CALCIUM ION, Magnesium transporter MgtE | | 著者 | Takeda, H, Hattori, M, Nishizawa, T, Yamashita, K, Shah, S.T.A, Caffrey, M, Maturana, A.D, Ishitani, R, Nureki, O. | | 登録日 | 2014-09-25 | | 公開日 | 2014-12-03 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg(2+) channel MgtE
Nat Commun, 5, 2014
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