8CWT
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4XNV
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![BU of 4xnv by Molmil](/molmil-images/mine/4xnv) | The human P2Y1 receptor in complex with BPTU | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-[2-(2-tert-butylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethoxy)phenyl]urea, CHOLESTEROL, ... | 著者 | Zhang, D, Gao, Z, Jacobson, K, Han, G.W, Stevens, R, Zhao, Q, Wu, B, GPCR Network (GPCR) | 登録日 | 2015-01-16 | 公開日 | 2015-04-01 | 最終更新日 | 2020-02-05 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Two disparate ligand-binding sites in the human P2Y1 receptor Nature, 520, 2015
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8J6H
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4QEX
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![BU of 4qex by Molmil](/molmil-images/mine/4qex) | Crystal structure of PfEBA-175 RII in complex with a Fab fragment from inhibitory antibody R217 | 分子名称: | Antibody Heavy Chain, Antibody Light Chain, Erythrocyte-binding antigen-175 | 著者 | Chen, E, Paing, M.M, Salinas, N, Sim, B.K, Tolia, N.H. | 登録日 | 2014-05-19 | 公開日 | 2014-06-04 | 実験手法 | X-RAY DIFFRACTION (4.5 Å) | 主引用文献 | Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175. Plos Pathog., 9, 2013
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6P09
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![BU of 6p09 by Molmil](/molmil-images/mine/6p09) | Human DNA Ligase 1 Bound to an Adenylated, dideoxy Terminated DNA nick with 200 mM Mg2+ | 分子名称: | ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... | 著者 | Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. | 登録日 | 2019-05-16 | 公開日 | 2019-12-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.052 Å) | 主引用文献 | Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
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7W0N
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![BU of 7w0n by Molmil](/molmil-images/mine/7w0n) | Cryo-EM structure of a dimeric GPCR-Gi complex with peptide | 分子名称: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, F, Yue, Y, Wu, L.J, Liu, L.E, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (4.21 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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8CYF
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![BU of 8cyf by Molmil](/molmil-images/mine/8cyf) | WhiB3 bound to SigmaAr4-RNAP Beta flap tip chimera and DNA | 分子名称: | CACODYLATE ION, DNA (5'-D(*CP*AP*CP*CP*AP*CP*AP*AP*CP*CP*GP*AP*TP*TP*TP*T)-3'), DNA (5'-D(*GP*AP*AP*AP*AP*TP*CP*GP*GP*TP*TP*GP*TP*GP*GP*T)-3'), ... | 著者 | Wan, T, Zhang, L.M. | 登録日 | 2022-05-23 | 公開日 | 2023-05-17 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Structural basis of DNA binding by the WhiB-like transcription factor WhiB3 in Mycobacterium tuberculosis. J.Biol.Chem., 299, 2023
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7W0L
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![BU of 7w0l by Molmil](/molmil-images/mine/7w0l) | Cryo-EM structure of a dimeric GPCR-Gi complex with small molecule | 分子名称: | (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yue, Y, Liu, L.E, Wu, L.J, Xu, F, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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4XTN
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![BU of 4xtn by Molmil](/molmil-images/mine/4xtn) | Crystal structure of the light-driven sodium pump KR2 in the pentameric red form, pH 4.9 | 分子名称: | EICOSANE, SODIUM ION, Sodium pumping rhodopsin, ... | 著者 | Gushchin, I, Shevchenko, V, Polovinkin, V, Gordeliy, V. | 登録日 | 2015-01-23 | 公開日 | 2015-04-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of a light-driven sodium pump. Nat.Struct.Mol.Biol., 22, 2015
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7W0O
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![BU of 7w0o by Molmil](/molmil-images/mine/7w0o) | Cryo-EM structure of a monomeric GPCR-Gi complex with peptide | 分子名称: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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7W0M
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![BU of 7w0m by Molmil](/molmil-images/mine/7w0m) | Cryo-EM structure of a monomeric GPCR-Gi complex with small molecule | 分子名称: | (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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7W0P
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![BU of 7w0p by Molmil](/molmil-images/mine/7w0p) | Cryo-EM structure of a GPCR-Gi complex with peptide | 分子名称: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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7Q9U
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7WFW
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![BU of 7wfw by Molmil](/molmil-images/mine/7wfw) | Apo human Nav1.8 | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, N, Pan, X.J, Huang, X.S, Huang, G.X. | 登録日 | 2021-12-27 | 公開日 | 2022-08-03 | 最終更新日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8. Proc.Natl.Acad.Sci.USA, 119, 2022
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7QJK
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![BU of 7qjk by Molmil](/molmil-images/mine/7qjk) | Crystal structure of PDE6D in complex with Compound-2 | 分子名称: | 1,2-ETHANEDIOL, N-(phenylmethyl)pyridin-2-amine, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ... | 著者 | Yelland, T, Ismail, S. | 登録日 | 2021-12-16 | 公開日 | 2022-01-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling. J.Med.Chem., 65, 2022
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7WFR
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![BU of 7wfr by Molmil](/molmil-images/mine/7wfr) | Human Nav1.8 with A-803467, class III | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, N, Pan, X.J, Huang, X.S, Huang, G.X. | 登録日 | 2021-12-27 | 公開日 | 2022-08-03 | 最終更新日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8. Proc.Natl.Acad.Sci.USA, 119, 2022
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7WEL
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![BU of 7wel by Molmil](/molmil-images/mine/7wel) | Human Nav1.8 with A-803467, class II | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, N, Pan, X.J, Huang, X.S, Huang, G.X. | 登録日 | 2021-12-23 | 公開日 | 2022-08-03 | 最終更新日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8. Proc.Natl.Acad.Sci.USA, 119, 2022
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4XQG
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6YPY
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7O0C
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![BU of 7o0c by Molmil](/molmil-images/mine/7o0c) | Human phosphomannomutase 2 (PMM2) wild-type in apo state | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Phosphomannomutase 2, ... | 著者 | Ramon-Maiques, S, Briso-Montiano, A, Del Cano-Ochoa, F, Vilas, A, Perez, B, Rubio, V. | 登録日 | 2021-03-26 | 公開日 | 2022-02-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures. J Inherit Metab Dis, 45, 2022
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6YR8
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![BU of 6yr8 by Molmil](/molmil-images/mine/6yr8) | Affimer K6 - KRAS protein complex | 分子名称: | Affimer K6, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C. | 登録日 | 2020-04-19 | 公開日 | 2020-07-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site. Nat Commun, 12, 2021
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7WE4
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![BU of 7we4 by Molmil](/molmil-images/mine/7we4) | Human Nav1.8 with A-803467, class I | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, N, Pan, X.J, Huang, X.S, Huang, G.X. | 登録日 | 2021-12-22 | 公開日 | 2022-08-03 | 最終更新日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8. Proc.Natl.Acad.Sci.USA, 119, 2022
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7O4G
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![BU of 7o4g by Molmil](/molmil-images/mine/7o4g) | Human phosphomannomutase 2 (PMM2) wild-type soaked with the activator glucose 1,6-bisphosphate | 分子名称: | 1,6-di-O-phosphono-alpha-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | 著者 | Ramon-Maiques, S, Briso-Montiano, A, Del Cano-Ochoa, F, Vilas, A, Perez, B, Rubio, V. | 登録日 | 2021-04-06 | 公開日 | 2022-02-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures. J Inherit Metab Dis, 45, 2022
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7O1B
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![BU of 7o1b by Molmil](/molmil-images/mine/7o1b) | Human phosphomannomutase 2 (PMM2) wild-type co-crystallized with the activator glucose 1,6-bisphosphate | 分子名称: | 1,6-di-O-phosphono-alpha-D-glucopyranose, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Ramon-Maiques, S, Briso-Montiano, A, Del Cano-Ochoa, F, Vilas, A, Perez, B, Rubio, V. | 登録日 | 2021-03-29 | 公開日 | 2022-02-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.08 Å) | 主引用文献 | Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures. J Inherit Metab Dis, 45, 2022
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7O5Z
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![BU of 7o5z by Molmil](/molmil-images/mine/7o5z) | Human phosphomannomutase 2 (PMM2) with mutation T237M in apo state | 分子名称: | CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... | 著者 | Ramon-Maiques, S, Briso-Montiano, A, Del Cano-Ochoa, F, Vilas, A, Perez, B, Rubio, V. | 登録日 | 2021-04-09 | 公開日 | 2022-02-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures. J Inherit Metab Dis, 45, 2022
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