7Q9U

Crystal structure of the high affinity KRas mutant PDE6D complex

This is a non-PDB format compatible entry.

Summary for 7Q9U

• Entry DOI: 10.2210/pdb7q9u/pdb
• Descriptor: GTPase KRas, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, GUANOSINE-5'-DIPHOSPHATE, ... (7 entities in total)
• Functional Keywords: cancer, drug discovery, complex, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 78923.69

Authors

Yelland, T.,Ismail, I. (deposition date: 2021-11-14, release date: 2022-01-26, Last modification date: 2024-01-31)

• Primary citation: Yelland, T.,Garcia, E.,Parry, C.,Kowalczyk, D.,Wojnowska, M.,Gohlke, A.,Zalar, M.,Cameron, K.,Goodwin, G.,Yu, Q.,Zhu, P.C.,ElMaghloob, Y.,Pugliese, A.,Archibald, L.,Jamieson, A.,Chen, Y.X.,McArthur, D.,Bower, J.,Ismail, S.; Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.; J.Med.Chem., 65:1898-1914, 2022; PubMed: 35104933; DOI: 10.1021/acs.jmedchem.1c01265

Experimental method

X-RAY DIFFRACTION (2.238 Å)