7Q9U

Crystal structure of the high affinity KRas mutant PDE6D complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000139	cellular_component	Golgi membrane
AAA	0000164	cellular_component	protein phosphatase type 1 complex
AAA	0000165	biological_process	MAPK cascade
AAA	0000166	molecular_function	nucleotide binding
AAA	0001889	biological_process	liver development
AAA	0003924	molecular_function	GTPase activity
AAA	0003925	molecular_function	G protein activity
AAA	0005515	molecular_function	protein binding
AAA	0005525	molecular_function	GTP binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005741	cellular_component	mitochondrial outer membrane
AAA	0005789	cellular_component	endoplasmic reticulum membrane
AAA	0005829	cellular_component	cytosol
AAA	0005886	cellular_component	plasma membrane
AAA	0005925	cellular_component	focal adhesion
AAA	0007165	biological_process	signal transduction
AAA	0007265	biological_process	Ras protein signal transduction
AAA	0007565	biological_process	female pregnancy
AAA	0008284	biological_process	positive regulation of cell population proliferation
AAA	0009629	biological_process	response to gravity
AAA	0009898	cellular_component	cytoplasmic side of plasma membrane
AAA	0010628	biological_process	positive regulation of gene expression
AAA	0012505	cellular_component	endomembrane system
AAA	0016020	cellular_component	membrane
AAA	0016787	molecular_function	hydrolase activity
AAA	0019002	molecular_function	GMP binding
AAA	0019003	molecular_function	GDP binding
AAA	0019221	biological_process	cytokine-mediated signaling pathway
AAA	0030275	molecular_function	LRR domain binding
AAA	0035900	biological_process	response to isolation stress
AAA	0043495	molecular_function	protein-membrane adaptor activity
AAA	0044877	molecular_function	protein-containing complex binding
AAA	0046579	biological_process	positive regulation of Ras protein signal transduction
AAA	0051384	biological_process	response to glucocorticoid
AAA	0051385	biological_process	response to mineralocorticoid
AAA	0051450	biological_process	myoblast proliferation
AAA	0060038	biological_process	cardiac muscle cell proliferation
AAA	2000774	biological_process	positive regulation of cellular senescence
BBB	0000139	cellular_component	Golgi membrane
BBB	0000164	cellular_component	protein phosphatase type 1 complex
BBB	0000165	biological_process	MAPK cascade
BBB	0000166	molecular_function	nucleotide binding
BBB	0001889	biological_process	liver development
BBB	0003924	molecular_function	GTPase activity
BBB	0003925	molecular_function	G protein activity
BBB	0005515	molecular_function	protein binding
BBB	0005525	molecular_function	GTP binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005741	cellular_component	mitochondrial outer membrane
BBB	0005789	cellular_component	endoplasmic reticulum membrane
BBB	0005829	cellular_component	cytosol
BBB	0005886	cellular_component	plasma membrane
BBB	0005925	cellular_component	focal adhesion
BBB	0007165	biological_process	signal transduction
BBB	0007265	biological_process	Ras protein signal transduction
BBB	0007565	biological_process	female pregnancy
BBB	0008284	biological_process	positive regulation of cell population proliferation
BBB	0009629	biological_process	response to gravity
BBB	0009898	cellular_component	cytoplasmic side of plasma membrane
BBB	0010628	biological_process	positive regulation of gene expression
BBB	0012505	cellular_component	endomembrane system
BBB	0016020	cellular_component	membrane
BBB	0016787	molecular_function	hydrolase activity
BBB	0019002	molecular_function	GMP binding
BBB	0019003	molecular_function	GDP binding
BBB	0019221	biological_process	cytokine-mediated signaling pathway
BBB	0030275	molecular_function	LRR domain binding
BBB	0035900	biological_process	response to isolation stress
BBB	0043495	molecular_function	protein-membrane adaptor activity
BBB	0044877	molecular_function	protein-containing complex binding
BBB	0046579	biological_process	positive regulation of Ras protein signal transduction
BBB	0051384	biological_process	response to glucocorticoid
BBB	0051385	biological_process	response to mineralocorticoid
BBB	0051450	biological_process	myoblast proliferation
BBB	0060038	biological_process	cardiac muscle cell proliferation
BBB	2000774	biological_process	positive regulation of cellular senescence
CCC	0005095	molecular_function	GTPase inhibitor activity
CCC	0005515	molecular_function	protein binding
CCC	0005737	cellular_component	cytoplasm
CCC	0005829	cellular_component	cytosol
CCC	0005929	cellular_component	cilium
CCC	0007601	biological_process	visual perception
CCC	0030659	cellular_component	cytoplasmic vesicle membrane
CCC	0031267	molecular_function	small GTPase binding
CCC	0031410	cellular_component	cytoplasmic vesicle
CCC	0050953	biological_process	sensory perception of light stimulus
DDD	0005095	molecular_function	GTPase inhibitor activity
DDD	0005515	molecular_function	protein binding
DDD	0005737	cellular_component	cytoplasm
DDD	0005829	cellular_component	cytosol
DDD	0005929	cellular_component	cilium
DDD	0007601	biological_process	visual perception
DDD	0030659	cellular_component	cytoplasmic vesicle membrane
DDD	0031267	molecular_function	small GTPase binding
DDD	0031410	cellular_component	cytoplasmic vesicle
DDD	0050953	biological_process	sensory perception of light stimulus

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"30442762","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Region: {"description":"Required for association with membranes","evidences":[{"source":"PubMed","id":"9712853","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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