7Q9U

Crystal structure of the high affinity KRas mutant PDE6D complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000139	cellular_component	Golgi membrane
AAA	0000165	biological_process	MAPK cascade
AAA	0001934	biological_process	positive regulation of protein phosphorylation
AAA	0003924	molecular_function	GTPase activity
AAA	0003925	molecular_function	G protein activity
AAA	0005515	molecular_function	protein binding
AAA	0005525	molecular_function	GTP binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005741	cellular_component	mitochondrial outer membrane
AAA	0005789	cellular_component	endoplasmic reticulum membrane
AAA	0005829	cellular_component	cytosol
AAA	0005886	cellular_component	plasma membrane
AAA	0005925	cellular_component	focal adhesion
AAA	0007165	biological_process	signal transduction
AAA	0007265	biological_process	Ras protein signal transduction
AAA	0008283	biological_process	cell population proliferation
AAA	0008542	biological_process	visual learning
AAA	0009898	cellular_component	cytoplasmic side of plasma membrane
AAA	0010467	biological_process	gene expression
AAA	0010628	biological_process	positive regulation of gene expression
AAA	0012505	cellular_component	endomembrane system
AAA	0014009	biological_process	glial cell proliferation
AAA	0016020	cellular_component	membrane
AAA	0016601	biological_process	Rac protein signal transduction
AAA	0016787	molecular_function	hydrolase activity
AAA	0019003	molecular_function	GDP binding
AAA	0021897	biological_process	forebrain astrocyte development
AAA	0030036	biological_process	actin cytoskeleton organization
AAA	0030857	biological_process	negative regulation of epithelial cell differentiation
AAA	0032228	biological_process	regulation of synaptic transmission, GABAergic
AAA	0035022	biological_process	positive regulation of Rac protein signal transduction
AAA	0035914	biological_process	skeletal muscle cell differentiation
AAA	0043495	molecular_function	protein-membrane adaptor activity
AAA	0043524	biological_process	negative regulation of neuron apoptotic process
AAA	0044877	molecular_function	protein-containing complex binding
AAA	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
AAA	0048873	biological_process	homeostasis of number of cells within a tissue
AAA	0051146	biological_process	striated muscle cell differentiation
AAA	0051402	biological_process	neuron apoptotic process
AAA	0060252	biological_process	positive regulation of glial cell proliferation
AAA	0060441	biological_process	epithelial tube branching involved in lung morphogenesis
AAA	0060509	biological_process	type I pneumocyte differentiation
BBB	0000139	cellular_component	Golgi membrane
BBB	0000165	biological_process	MAPK cascade
BBB	0001934	biological_process	positive regulation of protein phosphorylation
BBB	0003924	molecular_function	GTPase activity
BBB	0003925	molecular_function	G protein activity
BBB	0005515	molecular_function	protein binding
BBB	0005525	molecular_function	GTP binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005741	cellular_component	mitochondrial outer membrane
BBB	0005789	cellular_component	endoplasmic reticulum membrane
BBB	0005829	cellular_component	cytosol
BBB	0005886	cellular_component	plasma membrane
BBB	0005925	cellular_component	focal adhesion
BBB	0007165	biological_process	signal transduction
BBB	0007265	biological_process	Ras protein signal transduction
BBB	0008283	biological_process	cell population proliferation
BBB	0008542	biological_process	visual learning
BBB	0009898	cellular_component	cytoplasmic side of plasma membrane
BBB	0010467	biological_process	gene expression
BBB	0010628	biological_process	positive regulation of gene expression
BBB	0012505	cellular_component	endomembrane system
BBB	0014009	biological_process	glial cell proliferation
BBB	0016020	cellular_component	membrane
BBB	0016601	biological_process	Rac protein signal transduction
BBB	0016787	molecular_function	hydrolase activity
BBB	0019003	molecular_function	GDP binding
BBB	0021897	biological_process	forebrain astrocyte development
BBB	0030036	biological_process	actin cytoskeleton organization
BBB	0030857	biological_process	negative regulation of epithelial cell differentiation
BBB	0032228	biological_process	regulation of synaptic transmission, GABAergic
BBB	0035022	biological_process	positive regulation of Rac protein signal transduction
BBB	0035914	biological_process	skeletal muscle cell differentiation
BBB	0043495	molecular_function	protein-membrane adaptor activity
BBB	0043524	biological_process	negative regulation of neuron apoptotic process
BBB	0044877	molecular_function	protein-containing complex binding
BBB	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
BBB	0048873	biological_process	homeostasis of number of cells within a tissue
BBB	0051146	biological_process	striated muscle cell differentiation
BBB	0051402	biological_process	neuron apoptotic process
BBB	0060252	biological_process	positive regulation of glial cell proliferation
BBB	0060441	biological_process	epithelial tube branching involved in lung morphogenesis
BBB	0060509	biological_process	type I pneumocyte differentiation
CCC	0005095	molecular_function	GTPase inhibitor activity
CCC	0005515	molecular_function	protein binding
CCC	0005737	cellular_component	cytoplasm
CCC	0005829	cellular_component	cytosol
CCC	0005856	cellular_component	cytoskeleton
CCC	0005929	cellular_component	cilium
CCC	0007601	biological_process	visual perception
CCC	0016020	cellular_component	membrane
CCC	0030659	cellular_component	cytoplasmic vesicle membrane
CCC	0031267	molecular_function	small GTPase binding
CCC	0031410	cellular_component	cytoplasmic vesicle
CCC	0042995	cellular_component	cell projection
CCC	0050953	biological_process	sensory perception of light stimulus
DDD	0005095	molecular_function	GTPase inhibitor activity
DDD	0005515	molecular_function	protein binding
DDD	0005737	cellular_component	cytoplasm
DDD	0005829	cellular_component	cytosol
DDD	0005856	cellular_component	cytoskeleton
DDD	0005929	cellular_component	cilium
DDD	0007601	biological_process	visual perception
DDD	0016020	cellular_component	membrane
DDD	0030659	cellular_component	cytoplasmic vesicle membrane
DDD	0031267	molecular_function	small GTPase binding
DDD	0031410	cellular_component	cytoplasmic vesicle
DDD	0042995	cellular_component	cell projection
DDD	0050953	biological_process	sensory perception of light stimulus

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140

Chain	Residue	Details
AAA	GLY10
AAA	VAL29
AAA	ALA59
AAA	ASN116
BBB	GLY10
BBB	VAL29
BBB	ALA59
BBB	ASN116

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17

Chain	Residue	Details
AAA	MET1
BBB	MET1

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17

Chain	Residue	Details
AAA	THR2
BBB	THR2

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838

Chain	Residue	Details
AAA	LYS104
BBB	LYS104

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000305|PubMed:29239724

Chain	Residue	Details
AAA	LYS180
BBB	LYS180

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	LIPID: N6-palmitoyl lysine => ECO:0000269|PubMed:29239724

Chain	Residue	Details
AAA	SER182
BBB	SER182

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	LIPID: N6-palmitoyl lysine => ECO:0000305|PubMed:29239724

Chain	Residue	Details
AAA	ILE184
AAA	CMT185
BBB	ILE184
BBB	CMT185

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486

Chain	Residue	Details
AAA	THR35
BBB	THR35

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:30442762

Chain	Residue	Details
AAA	MET170
BBB	MET170

---